|Study offers new theory of cancer development|
“If you look at a cancer cell, it looks like an unholy mess with gene deletions and amplifications, chromosome gains and losses, like someone threw a stick of dynamite into the cell. It seems random, but actually previous work has shown that there is a ...
The Almagest - Fri, 13 Dec 2013 06:48
|Early-onset Parkinson's disease linked to genetic deletion|
Scientists at the Centre for Addiction and Mental Health (CAMH) and University Health Network (UHN) have found a new link between early-onset Parkinson's disease and a piece of DNA missing from chromosome 22. The findings help shed new light on the ...
The Almagest - Sun, 24 Nov 2013 00:48
|Charity event raised £910 for disabled Stourbridge youngster|
Linda Tromans, aged 57, was touched when she heard that eight-year-old Luis Hickman had a rare condition called Chromosome 1p36 Deletion, which has left him facing a lifetime of mobility and communication problems, following an appeal his mother, ...
Stourbridge News - Thu, 12 Dec 2013 04:00
|Close look at autism-linked region reveals complex biology|
Having too many or too few copies of a gene, or a chromosomal region, would presumably have opposite effects on the body. But that's not always the case, new research suggests. Deletions or duplications of large stretches of DNA, called copy number ...
SFARI News - Wed, 27 Nov 2013 20:27
|UC Davis MIND Institute's “Thank you” to research participants|
Research at the MIND Institute has expanded from autism to include Attention Deficit Hyperactivity Disorder (ADHD), Chromosome 22q11.2 deletion syndrome, Down syndrome, and fragile X syndrome. Although research remains the MIND Institute's primary ...
San Francisco Chronicle (blog) - Tue, 10 Dec 2013 11:52
|Latest Data Further Support Ibrutinib's Efficacy in CLL|
The oral drug received a Breakthrough Therapy Designation from the FDA in April 2013 for particularly poor prognosis and high-risk CLL or small lymphocytic lymphoma (SLL) patients who carry a deletion in chromosome 17 (17p deletion). CLL patients who ...
OncLive - Tue, 10 Dec 2013 20:45
|UCSD Team Develops PacBio Sequencing Method to ID Structural Variant ...|
Aside from the CDKN2A deletions, the team also demonstrated the method on a more complex structural variant, a gene fusion between RUNX1 and RUNX1T1, the result of an interchromosomal translocation between chromosomes 8 and 21.
GenomeWeb - Tue, 10 Dec 2013 10:28
|Gilead Announces Interim Phase 2 Results for GS-9973 in Previously Treated ...|
Of the 29 CLL patients included in the efficacy analysis, 20 (69 percent) achieved greater than 50 percent tumor shrinkage, including four of seven patients with a chromosome 17p deletion and/or a mutation in the TP53 gene, genetic abnormalities that ...
Wall Street Journal - Sat, 07 Dec 2013 15:26