An antibody to amphiregulin, an abundant growth factor in patients' fluids ...
A related pattern was observed in media conditioned by 13 ovarian cancer cell lines (Figure 1c): AREG (92% of the analyzed cell lines), TGF-alpha (69%), HB-EGF (54%) and NRG1 were detectable, though the latter was observed in only one cell line ...
Nature.com - Mon, 27 Apr 2015 06:34

Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis
Furthermore, a recent study implicated CEP55 as a driver of FOXM1 expression in oral cavity squamous cell carcinoma lines wherein CEP55 upregulates FOXM1 levels in a dose-dependent manner, which results in increased transcription of MMP-2 and a ...
Nature.com - Mon, 27 Apr 2015 06:30

MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7
miR-17-5p, an important member of the miR-17–92 cluster, plays a crucial role in regulating cell functions, such as proliferation and migration, and is overexpressed in various cancers, including hepatocellular carcinoma (HCC). miR-17-5p is reported to ...
Nature.com - Mon, 27 Apr 2015 07:21

Paxillin confers resistance to tyrosine kinase inhibitors in EGFR-mutant lung ...
Tyrosine kinase inhibitors (TKIs) have been documented to have substantial clinical benefits to non-small cell lung cancer with epidermal growth factor receptor (EGFR) mutation. TKI resistance occurs in nearly all patients who receive TKI-targeting ...
Nature.com - Mon, 27 Apr 2015 06:34

Calithera Biosciences Highlights Results From Six Preclinical Abstracts at the ...
"We have identified KRAS and EGFR mutation status as potential biomarkers correlated to enhanced sensitivity of CB-839, which could ultimately direct our development of CB-839 in non-small cell lung cancer. In addition, based on our synergy studies, ...
GlobeNewswire (press release) - Tue, 21 Apr 2015 04:37



New Optical Device to Diagnose Basal Cell Carcinoma
A new optical technology called multiphoton microscopy (MPM) could allow for noninvasive, painless, and rapid diagnosis of basal cell carcinomas (BCCs) in the clinic, according to a small pilot study published online April 24 in JAMA Dermatology. The ...
Medscape - Fri, 24 Apr 2015 11:00



Is Immuno-Oncology the Best Area of Biotech to Invest in Right Now?
So far, these two drugs have shown some astounding results in several cancers, including advanced melanoma, non-small cell lung cancer, and renal cell carcinoma, among others. Some experts believe Opdivo could rake in over $7 billion in sales for its ...
Motley Fool - Wed, 22 Apr 2015 05:11

Mylan Issues Nationwide Recall of Gemcitabine, Other Drugs
Gemcitabine is an intravenously administered product indicated for the treatment of ovarian cancer, breast cancer, non-small-cell lung cancer, and pancreatic cancer. The recalled lots were distributed in the US between February 18, 2014, and December ...
Medscape - Fri, 24 Apr 2015 16:26

Numerous Injectable Products Recalled Due to Foreign Matter
Monthly Prescribing Reference - Fri, 24 Apr 2015 12:52

Mylan Initiates Voluntary Nationwide Recall of Select Lots of Injectable ...
EIN News (press release) - Fri, 24 Apr 2015 11:11


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