|KMTase Set7/9 is a critical regulator of E2F1 activity upon genotoxic stress|
To test this hypothesis, we analysed cell-cycle distribution of non-small human lung carcinoma cells, H1299, with short hairpin RNA (shRNA)-mediated knockdown of Set7/9 (H1299 Set9KD), along with parental cells transfected with control shRNA (H1299) ...
Nature.com - Fri, 15 Aug 2014 04:57
|Researchers ID genetic alterations, shedding light on hereditary melanoma|
“In theory, any genetic alteration that upregulates oncogenes and downregulates tumor suppressor cells could predispose individuals to melanoma,” he says. The discovery ... “The study was small in number and therefore needs to be replicated. If it ...
ModernMedicine - Mon, 18 Aug 2014 10:26
|Lymphocyte count predicts papillary RCC patient survival|
Lymphopenia is a significant predictor of outcome in patients undergoing surgery for papillary renal cell carcinoma (PRCC), US researchers report. The team says that the preoperative absolute lymphocyte count ... There was also a strong trend towards ...
News-Medical.net - Mon, 18 Aug 2014 14:11
|Merck Serono enters anti-PD-1 fray|
The mid-stage trial of the company's candidate - called MSB0010718C - is in patients with metastatic Merkel cell carcinoma (MCC), a cancer which currently has few effective treatment options. The company is planning to ... Over-expression of PD-L1 has ...
PMLiVE - Wed, 30 Jul 2014 03:41
|Merck Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in ...|
PipelineReview.com (press release) - Mon, 28 Jul 2014 23:22
|EMD Serono begins phase II study of anti-PD-L1 antibody MSB0010718C in ...|
pharmabiz.com - Tue, 29 Jul 2014 22:26
|Small companies lead the IO class of Cancer Therapies|
Los Angeles, CA / August 8, 2014 / Tumor cells, tending to persist after treatment, lead to remission and have been a bane to cancer researchers and doctors for decades. Only recently, immuno-oncology, labeled 'I-O' first by Bristol-Myers Squibb ...
Baystreet.ca - Fri, 08 Aug 2014 05:00
|Avastin Wins FDA Nod for Advanced Forms of Cervical Cancer|
Avastin's other approved U.S. indications include treatment of colorectal cancer, non-small cell lung cancer, kidney cancer, and progressive glioblastoma following prior therapy. In Europe, Avastin is additionally indicated for advanced stages of ...
Genetic Engineering & Biotechnology News - Fri, 15 Aug 2014 07:03
|FDA approves Avastin for treatment of advanced cervical cancer|
Bevacizumab is now approved in the United States for treatment of five tumor types — cervical cancer, metastatic colorectal cancer, metastatic renal cell carcinoma, nonsquamous non–small cell lung cancer and recurrent glioblastoma. The FDA based the ...
Healio - Thu, 14 Aug 2014 16:26
|US lung cancer rates vary by subtype, sex, race/ethnicity, and age|
Their goal was to update the classification of lung cancer subtypes and to determine the rates of lung cancer overall as well as the rates of squamous cell, small cell, adenocarcinoma, large cell, other, and unspecified carcinomas among US whites and ...
EurekAlert (press release) - Tue, 05 Aug 2014 22:48