An experimental animal model for the demyelinating disease of GUILLAINE-BARRE syndrome. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the myelin p2 protein in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)