Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same ribonuclease iii, Dicer, that produces small interfering RNAs (rna, small interfering). They become part of the rna-induced silencing complex and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.


Symptoms and diagnosis

Symptoms:

    


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