Holoprosencephaly
(Arhinencephaly; Alobar Holoprosencephaly; Lobar Holoprosencephaly; Semilobar Holoprosencephaly)


Anterior midline brain, cranial, and facial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. Alobar prosencephaly is the most severe form and features anophthalmia; cyclopia; severe intellectual disability; cleft lip; cleft palate; seizures; and microcephaly. Semilobar holoprosencepaly is characterized by hypotelorism, microphthalmia, coloboma, nasal malformations, and variable degrees of intellectual disability. Lobar holoprosencephaly is associated with mild (or absent) facial malformations and intellectual abilities that range from mild intellectual disability to normal. holoprosencephaly is associated with CHROMOSOME ABNORMALITIES.

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In lobar <b>holoprosencephaly</b>

In lobar holoprosencephaly
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<b>holoprosencephaly</b>

holoprosencephaly
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<b>Holoprosencephaly</b> | Radiology

Holoprosencephaly | Radiology
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in <b>Holoprosencephaly</b> with

in Holoprosencephaly with
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Lobar <b>holoprosencephaly</b>

Lobar holoprosencephaly
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Lobar <b>holoprosencephaly</b>

Lobar holoprosencephaly
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Diagnosis and therapies


Symptoms:

    

More information


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  • MeSH - Medical Subject Headings.
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Last update: April 2009
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