(Arhinencephaly; Alobar Holoprosencephaly; Lobar Holoprosencephaly; Semilobar Holoprosencephaly)

Anterior midline brain, cranial, and facial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. Alobar prosencephaly is the most severe form and features anophthalmia; cyclopia; severe mental retardation; cleft lip; cleft palate; seizures; and microcephaly. Semilobar holoprosencepaly is characterized by hypotelorism, microphthalmia, coloboma, nasal malformations, and variable degrees of mental retardation. Lobar holoprosencephaly is associated with mild (or absent) facial malformations and intellectual abilities that range from mild mental retardation to normal. holoprosencephaly is associated with CHROMOSOME abnormalities.


Powered by

In lobar <b>holoprosencephaly</b>
In lobar holoprosencephaly

Lobar <b>holoprosencephaly</b>
Lobar holoprosencephaly

Case 4. Drag here to reorder.
Case 4. Drag here to reorder.

<b>Holoprosencephaly</b> | Radiology
Holoprosencephaly | Radiology


Lobar <b>holoprosencephaly</b>
Lobar holoprosencephaly

in <b>Holoprosencephaly</b> with
in Holoprosencephaly with

<b>Holoprosencephaly</b> | Radiology
Holoprosencephaly | Radiology

Diagnosis and therapies



Fast   Hierarchical


HoloprosencephalyHypotelorismCebocephalyEthmocephalyProsencephalonLancia BetaTGIF2TGIFTgif (program)TGIF (disambiguation)

More information

  • Reported cases - Summary of cases reported on this disease.
  • Related terms - Look for sites, images, videos, news and articles about related terms.
  • SearchMedica - Professional Medical Search.
  • WHO - World Health Organization.
  • PubMed - A service of the National Library of Medicine and National Institutes of Health.
  • MEDLINE - Literature from the National Library of Medicine.
  • MeSH - Medical Subject Headings.
  • DeCS - Health Sciences Descriptors.

Comments on "Holoprosencephaly"

  • I just received that my my unborn son has holoprosencephaly. I am 6 months pregnant and cannot believe that in 2 days i will have to end my pregnancy. I am both sad and in denial my doctor says that i am in survival mode and after the pregnancy has been te...  (+)
  • I have a 5 years old beautiful girl with semi lobar holoprosencephaly. She does not speak or walk. She is completely dependent. She eats by mouth and is otherwise healthy. It's been hard and an emotional roller coaster. She is very difficult to care for. S...  (+)
  • I was 14 weeks pregnant and went for the routine ultrasound. Suddenly after doing the ultrasound, doctor told me that your pregnancy is not healthy as it is showing the symptoms of semilobor holoprosencephaly in which the brain of the baby is partially dev...  (+)
  • i was pregnant with my first chld and she was diagnosed with an alobar holoprosencephaly , i wanna have another baby but im scared this will happen again, does anyone kno if this will happen to me again ?]  (+)

Leave a message or picture about "Holoprosencephaly" or enter the forum

We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.
Last update: April 2009