A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with calgranulin b and a variety of other proteins. The calgranulin a/B heterodimer is known as leukocyte l1 antigen complex. calgranulin a is found in many cell types including granulocytes; keratinocytes; and myelomonocytes, and has been shown to act as a chemotactic substance for neutrophils. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.