Tay-Sachs Disease
(Gangliosidosis G(M2), Type I; G(M2) Gangliosidosis, Type I; Gangliosidosis GM2, B Variant; Hexosaminidase A Deficiency Disease; Tay-Sachs Disease, B Variant)

An autosomal recessive neurodegenerative disorder characterized by the onset in infancy of an exaggerated startle response, followed by paralysis, dementia, and blindness. It is caused by mutation in the alpha subunit of the hexosaminidase a resulting in lipid-laden ganglion cells. It is also known as the B variant (with increased hexosaminidase b but absence of hexosaminidase a) and is strongly associated with Ashkenazic Jewish ancestry.


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The Cure <b>Tay</b>-<b>Sachs</b> Foundation

The Cure Tay-Sachs Foundation

Causes of <b>Tay</b>-<b>Sachs Disease</b> by

Causes of Tay-Sachs Disease by

But a baby with <b>Tay</b>-<b>Sachs</b>

But a baby with Tay-Sachs

<b>Tay Sachs disease</b> Pictures

Tay Sachs disease Pictures

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<b>Tay</b>-<b>Sachs Disease</b>

Tay-Sachs Disease

<b>Tay</b>-<b>Sachs Disease</b>

Tay-Sachs Disease

Diagnosis and therapies



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Last update: April 2009