Some people with a deficit of IgA exhibit recurrent respiratory tract infections. Explain this observation.?

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I know that IgA is also called secretory IgA, it is found in mucus and other secretions, and it plays major role in preventing pathogens from getting into the body. But I still cannot understand how is it related to recurrent respiratory infections.... HELP please!
Streptococcus pneumoniae and Haemophilus influenzae are important bacteria in recurrent respiratory infections. The immunological response against them is based on the synthesis of specific immunoglobulins, the generation of complement factors, and phagocytosis.

The role and relative frequency of the above-mentioned in increased susceptibility to respiratory infections is poorly understood. Neither is it known whether the combined presence of several (partial) immune defects contributes to increased susceptibility to infection.   (+ info)

have you ever been to brigidos IGA fresh market?

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Is it nice? is there a wide selection is it the store i can count on every week for groceries i used to use stop and shop but theres not one around us anymore so help please?
wow... I haven't been, but you can only try it out..... and see....  (+ info)

I lost the IGA certificate for a diamond ring - how can I replace it?

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The diamond is almost perfect - now I want to sell it. The IGA certicicate number is on an apraisal I got about 3 years ago. How can I get a replacement certifcate? Or is it even necessary if I sell it?

I Googled, but found nothing.

Thanks!
You should be able to contact the IGA lab directly and explain your situation. If you do have the correct certificate number they should be able to locate the information they have on it and re-issue a certificate for your diamond for a fee. All labs have copies of all their certificates on file. In regards to having a certificate for your diamond. I will always argue that it will be better and of more help to have one then not having one. All the best to you!  (+ info)

What is Focal Sclerosing Glomerulonephritis?

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I was always told I had urinary reflux when I was born but was finally diagnosed at the age of 9 with Pylonephritis.

I don't get why in 2005 when I was hospitalized they put on my medical records that I had Focal Sclerosing Glomerulonephritis.

So now I am trying to find what that is (thought maybe just another name for what I had) but there is very little information on the net on this .. especially something easy to understand.

Does anyone know the answer?
I understand the term as Focal Segmental Glomerulosclerosis. This may help in your search.

This is a disease of the kidneys of an unknown cause. It is characterised by hyaline deposition in the glomeruli of the kidneys (the bit of the kidney that does all the filtering of the blood).

Hyaline is a compound found in the body. If it deposits on the glomerulus, what can happen is that the cells of the immune system bind to it and attack it, trying to clear it from the kidney. A side affect of this is that the immune cells often do even further damage to the glomerulus causing the sclerosis (thickening due to damage).

The impairment is generally progressive and is characterised by loss of protein in the urine (proteinuria). This may cause swelling in the body, particularly of the face and around the eyes. The person may also develop hypertension.

You would usually be diagnosed with this condition after a renal biopsy. If you've not had a biopsy this is perhaps just a working diagnosis and it might be something else which is causing problems for your kidneys.   (+ info)

How do I make sushi without seaweed. I don't want to look like a idiot going into IGA asking for sea weed.

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you have to get special rice for sushi . and don't worry about looking dumb , ask for sushi seaweed wraps , any person in a supermarket should know what you are talking about .  (+ info)

Can I donate blood with IgA and IgG deficiencies?

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They're rather mild deficiencies, but noticeable in count nonetheless.
I'm pretty sure you still can, because it wouldn't interfere with the RH or blood types. But ask a doctor to be sure.  (+ info)

My friend,28, has glomerulonephritis in Stage 3 renal disease. If he follows treatment how long can he live?

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The disease is chronic and I am researching it but cannont find answers for average life expectancy with proper management of the disease?
He could actually live for a long time. A lot depends on exactly what set off the kidney failure. He should be under the care of a nephrologist. Also, dialysis is in his future.  (+ info)

Why doesnt IGA or woolworths sell that Heinz Big EAt Ravioli anymore? they sell a different one now =(?

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it used to be in a small can, now its in a big can and its more like soup and tastes different... so devo
go to another store and buy it.  (+ info)

How does IgA affect human immune system?

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What factors to cause such a disease to human?
IgA Nephropathy
IgA nephropathy is a kidney disorder caused by deposits of the protein immunoglobulin A (IgA) inside the glomeruli (filters) within the kidney. These glomeruli (the singular form is glomerulus) normally filter wastes and excess water from the blood and send them to the bladder as urine. The IgA protein prevents this filtering process, leading to blood and protein in the urine and swelling in the hands and feet. This chronic kidney disease may progress over a period of 10 to 20 years. If this disorder leads to end-stage renal disease, the patient must go on dialysis or receive a kidney transplant.

The IgA protein, an antibody, is a normal part of the body's immune system, the system that protects against disease. We do not know what causes IgA deposits in the glomeruli. But, since IgA nephropathy may run in families, genetic factors probably contribute to the disease.

Kidney disease usually cannot be cured. Once the tiny filtering units are damaged, they cannot be repaired. Treatment focuses on slowing the progression of the disease and preventing complications. One complication is high blood pressure, which further damages glomeruli. A class of medicines called ACE inhibitors protects kidney function not only by lowering blood pressure but also by reducing the loss of protein into the urine.

Some patients may benefit from limiting protein in their diet to reduce the buildup of waste in the blood. Patients with IgA nephropathy often have high cholesterol. Reducing cholesterol—through diet, medication, or both—appears to help slow the progression of IgA nephropathy.

Corticosteroids may suppress the production of IgA but can have harmful side effects. In preliminary studies, fish oil supplements containing omega 3 fatty acids also appear to slow the progression of the kidney disease. A new immunosuppressive agent called mycophenolate mofetil (MMF) is also being tested.

For More Information

American Kidney Fund
6110 Executive Boulevard, Suite 1010
Rockville, MD 20852
Phone: 1–800–638–8299 or 301–881–3052
Email: [email protected]
Internet: www.kidneyfund.org

IgA Nephropathy Support Network
9 G Street, Apt. B
Turners Falls, MA 01376
Phone: 413–863–8663

National Heart, Lung, and Blood Institute Health Information Center
P.O. Box 30105
Bethesda, MD 20824–0105
Phone: 301–592–8573
Email: [email protected]
Internet: www.nhlbi.nih.gov

National Kidney Foundation
30 East 33rd Street
New York, NY 10016
Phone: 1–800–622–9010 or 212–889–2210
Email: [email protected]
Internet: www.kidney.org



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Additional Information on IgA Nephropathy

The National Kidney and Urologic Diseases Information Clearinghouse collects resource information on kidney and urologic diseases for the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Reference Collection. This database provides titles, abstracts, and availability information for health information and health education resources. The NIDDK Reference Collection is a service of the National Institutes of Health.

To provide you with the most up-to-date resources, information specialists at the clearinghouse created an automatic search of the NIDDK Reference Collection. To obtain this information, you may view the results of the automatic search on IgA Nephropathy.

If you wish to perform your own search of the database, you may access and search the NIDDK Reference Collection database online.


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National Kidney and Urologic Diseases Information Clearinghouse
3 Information Way
Bethesda, MD 20892–3580
Email: [email protected]

The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC) is a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health under the U.S. Department of Health and Human Services. Established in 1987, the Clearinghouse provides information about diseases of the kidneys and urologic system to people with kidney and urologic disorders and to their families, health care professionals, and the public. The NKUDIC answers inquiries, develops and distributes publications, and works closely with professional and patient organizations and Government agencies to coordinate resources about kidney and urologic diseases.

Publications produced by the Clearinghouse are carefully reviewed by both NIDDK scientists and outside experts.

This publication is not copyrighted. The Clearinghouse encourages users of this publication to duplicate and distribute as many copies as desired.


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NIH Publication No. 03–4571
August 2003

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