FAQ - Retinoblastoma
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Can somebody tell me a cure for retino blastoma. Cause cure and if hereditary, how to cure it. Please help?


Brief abt retinoblastoma or eye cancer. How does it occur. which parent or is it hereditary. If yes then how to remove it complete. Is it a virus in the body. Can it be corrected in the sperm. Or whats the cure of it.
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Retinoblastoma is caused by a defect on chromosome 13, resulting in spontaneous tumor formation in one or both eyes. 95% of patients are cured, and 90% of them retain at least some vision (partially because bilateral retinoblastoma is rare). Although the disease is hereditary, only 10% of RB patients have an older relative who also has the disease.

#1 treatment is enucleation, i.e., removal of the eye. The tumors can't be excised because of the extreme likelihood of metastasis, i.e., spreading the cancer through the whole body. When the disease is present in both eyes, the usual treatment is to enucleate the worse eye and try treating the less-affected eye with lasers, radiation and chemotherapy. It cannot be corrected in the sperm, because (unless one parent has retinoblastoma) there's no way to be certain which parent is the source of the defect. And science has not reached the level where we can cull the spermatazoa that carry genetic defects. The Brave New World is coming, but it's not here yet.

The defect can sometimes by identified through amniocentesis or chorionic villi biopsy, but not always: maddeningly, sometimes the only cells with the defective genes are in the retina, and endodermal cells do not normally appear in the amniotic fluid.  (+ info)

I lost my eye due to a rare form of cancer and I was just wondering?


Hi all when I was 5 yr old I lost my eye due to RETINOBLASTOMA cancer. I had surgery not long ago to have the implant resettled and I was just wondering since yesterday I have been taking on dizzy spells. I know I have had some infestion and I was just wondering if there is anyone else out there who has had this problem at all?
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I would go to your doctor asap if you are having infections. That is too serious to mess with.  (+ info)

Please help... This is really urgent.. ?


Hi my sister has noticed when she takes photosof my niece one of her pupils is white whilst the other is red.She is seeing the specialist at 11am today after her husband took a photo to him and showed him. The doc said he is very worried.
After googling alot of pages are saying this is a majo symptom of a tumr in the retina (retinoblastoma).
Can anyone please offer advise?
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Some one asked a similar question on her a while ago, here's the link to the question http://ca.answers.yahoo.com/question/index;_ylt=Ash.2BlW4cjHU8Cx1iFQwybpFQx.;_ylv=3?qid=20080523171336AAkPqMo  (+ info)

genes in colorectal cancer?


in colorectal cancer, several genes must be mutated in order to make a cell a cancer cell, supporting Knudsen's hypothesis. which of the following kinds of genes would you expect to be mutated?

a. genes coding for enzymes that act in the colon
b. genes involved in control of the cell cycle
c. genes that are especially susceptible to mutation
d. the same genes that Knudsen identified as associated with retinoblastoma
e. the genes of the bacteria that are abundant in the colon
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b and d  (+ info)

Any help for my daughter?


my 5 year old daughter was seen by specialists in nyc due to a white pupil after tests they are still unsure what it is she was thought to have retinoblastoma now she is blind and we're still waiting for them to figure out what she has all they know is she is blind in that eye her pupil is white and her retina detached any help
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i would take her to wills eye hospital in philadelphia pa.
they are the second best hosiptal in the USA that deals with ONLY EYES.

just from my experience in my only life (visually impaired since birth, coloboma, 4 retinal detachments, glaucoma, and cataracts) i would say that the reason she cannot see is cuz her retina detached and either has not been treated with surgery at all or if she was treated with surgery that it was not in time and she lost her eye sight because of the time frame.
and the white pupil would indicate that she has a cataract.

here is a great link to learn about retinal detachment:
http://www.webmd.com/eye-health/tc/retinal-detachment-topic-overview
and here is a great link to learn about catarcts:
http://www.webmd.com/eye-health/cataracts/cataracts-topic-overview

and here is a link to the wills eye hospital website:
http://www.willseye.org/

please call them (215) 928-3300  (+ info)

Does anyone have any comments on this data concerning stem cell research? Embryonic benefits = NONE.?


Benefits of Stem Cells to Human Patients
Adult Stem Cells v. Embryonic Stem Cells
Download This List
Peer-Reviewed References (not a complete listing, sample references)
Adult Stem CellsCancers:

Brain Cancer
Retinoblastoma
Ovarian Cancer
Skin Cancer: Merkel Cell Carcinoma
Testicular Cancer
Tumors abdominal organs Lymphoma
Non-Hodgkin’s lymphoma
Hodgkin’s Lymphoma
Acute Lymphoblastic Leukemia
Acute Myelogenous Leukemia
Chronic Myelogenous Leukemia
Juvenile Myelomonocytic Leukemia
Chronic Myelomonocytic Leukemia
Cancer of the lymph nodes: Angioimmunoblastic Lymphadenopathy
Multiple Myeloma
Myelodysplasia
Breast Cancer
Neuroblastoma
Renal Cell Carcinoma
Various Solid Tumors
Soft Tissue Sarcoma
Ewing’s Sarcoma
Waldenstrom’s macroglobulinemia
Hemophagocytic lymphohistiocytosis
POEMS syndrome
Myelofibrosis
Auto-Immune Diseases

Diabetes Type I (Juvenile)
Systemic Lupus
Sjogren’s Syndrome
Myasthenia
Autoimmune Cytopenia
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Are you trying to make a political statement?

I am very much against abortion. However, embryonic stem cell research is NOT abortion. Those embryos will NEVER become a human. They will be disposed of anyways.

Scientifically, embryonic stem cells are easier to work with in research than adult stem cells.

I am familar with many treatments with adult stem cells and, I am quite skeptical of most of your list. The true list oif approved treatments is very limited.

Stop the propaganda. Support the science!!!!  (+ info)

ophthalmologist?


Why does the ophthalmologist dilate the pupil and look in the dark?
What is she looking for?
Would notice retinoblastoma?
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This examination enables your eye care professional to see more of your retina, the light-sensitive layer of tissue at the back of your eye.

Dilating (widening) the pupil permits the retina to be examined for signs of disease.

Retinoblastoma - will take additional testing to accurately diagnose besides just dilation.

Often the first sign of retinoblastoma that is noticed is leukocoria, a whitening of the pupil that looks like a "cat's eye". This whiteness can be seen in certain lighting conditions. It is often noticed in photographs of the child taken with a flash, which usually causes the eyes to appear red in the picture. Instead of the normal red reflex, you may notice a white pupil in the photo, which comes from the white surface of the tumor itself.  (+ info)

Question about leukocoria, or white pupil reflex, in a 3 week old baby? Please answer my question.?


I posted a similar question a few days ago. I took my 3 week old daughter to the family doc, and he looked in her eyes with that light thingy they use to check for red reflex. Now the lights in the room were not dimmed like it says they should be on all the sites i find. anyway he saw a white reflex in both eyes. he sent a referral to an opthalmologist. I am still waiting for the call for the appointmrnt. Anyway, a few days ago i looked at pictures that I had taken of my daughter at least a week before the doctor's appointment, and in the photos, where she was looking right at me, and also with her head slightly turned, I see a red pupil in both eyes. I took more pictures last night, (she turned 4 weeks yesterday) and she still has red pupil. The flash was on when i took the pics. I am worried about retinoblastoma, I am really scared, but most of what I see shows that with retinoblastoma there is no red reflex in pictures in the effected eye(s). Is it possible to still get the red eye reaction in photos if a person has retinoblastoma?? Or are there other reasons why he could have seen a white reflex in the pupil at the visit? Could it be because the lights were not dimmed, and the windows were open letting light in to the room? Im really worried about her vision. She seems to see well, she can follow movement since she was at least a week old, she notices colors, when I talk to her in front of her she smiles at me. Please give me some answers and advice on this.
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You can do ophthalmoscopy (the light thingy) in brighter light conditions so long as you can see what you're doing; when I was working in Africa, we did it outside fairly routinely. That being said, it can make things look brighter (more white than red) if you aren't used to it, but if your family doc normally does it with the lights on then that's probably not an issue.
Retinoblastoma isn't the only thing that causes a white pupil; I'm assuming you've been researching online enough to know that. It's actually one of the rarer things, but, being a tumor, it's one of the scarier ones as well. It's also one of the things that could occur in both eyes (unlike, for instance, Coat's disease), but that's even more uncommon.
You can still get a red reflex in photos if someone has retinoblastoma, depending on how big it is and where it is. (You can also get a white reflex in some people with normal eyes.) Bottom line is, the ophthalmologist is going to put some dilating drops in and have a much better look at what's going on with your daughter. More than likely your family doc is being overly cautious and referring you to a specialist when this is beyond his expertise or comfort level. The fact that your daughter seems to have good vision (and presumably doesn't have other eye problems, like an eye turn or anything) is also a good sign.
If you're still waiting on an ophthalmologist -- they often have long wait times -- you may be able to get an appointment with a pediatric optometrist in your area without needing a referral. They might be able to put your mind at ease (or bug the ophthalmologist to get an appointment sooner).  (+ info)

Only one eye. Can any one tell me what this is?


I lost my right eye to Retinoblastoma when I was 3. The doctors had to remove the eye. I am wondering if any one can tell me what this is in my eye Socket. It looks like an eye, but it is white with red veins run through out it. Can you tell me exactly what this is ? It is not my eye or is it ? I only see my optician once a year. Every time i see her i forget to ask her what this is. Any Professional help please and thank you.

http://en.wikipedia.org/wiki/Retinoblastoma
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Without examining you I would have to say what you are seeing is the residual tissue remaining after enucleation of the eye.

http://en.wikipedia.org/wiki/Enucleation  (+ info)

Question about possible white pupil reflex in three week old?


At her checkup yesterday the doc checked her eyes and said he saw her pupil reflecting white and made an appt with a specialist. I looked online as I never heard of it and found info on retinoblastoma. It scared me so much!! It said typically you can see the white pupil in photos also so I looked in pics I took a week before her appt and in some photos she had normal red eye in both eyes and there were no pics with white pupils. We only went to our family doc, and I'm wondering if maybe be didn't examine her eyes right. I'm just wondering what are the odds of her having retinoblastoma or some other problem, even though in photos she has the normal red reflex. Any info is helpful but please no spam.
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He's done the right thing - family doctors don't have enough experience with eyes to know everything so a specialist is the right route to go.

If you've seen red eye in both eyes in pictures then it is unlikely that it is retinoblastoma - you would probably be able to see the white reflex consistently in one eye.

Don't worry too much - you're doing the right thing and will get a definitive answer. On the positive side too retinoblastoma is very treatable - it has one of the best cure rates of all cancers.  (+ info)

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