How is Polycystic Kidney Disease inherited?
and is it a dominant trait, a recessive trait, or incomplete dominence?
ADPKD: Because PKD is an inherited disorder, the dominant form of the disease (ADPKD) is passed from one generation to the next by an affected parent. An ADPKD parent has a 50% chance of passing the PKD mutation to each of his/her children at conception - having a child who inherits ADPKD with each pregnancy, no matter how many children a person has. In some families, all the children are affected; in other families, none are. Many families with multiple children will have affected and unaffected children. Although most individuals with ADPKD have a family history, scientists have also discovered that approximately 10-20 percent of the PKD patient community became affected through spontaneous mutation.
Two genes that cause ADPKD have been identified. About 85% of people with ADPKD have mutations in the PKD1 gene, located on chromosome 16. The remaining 15% of individuals have mutations in the PKD2 gene located on chromosome 4. There are no other PKD genes that have been identified to date.
The disease caused by ADPKD1 is more severe than that caused by ADPKD2. Individuals with mutations in the PKD1 gene develop cysts, hypertension and loss of kidney function at an earlier age compared to the ADPKD2 gene.
ARPKD: This recessive disease requires a mutated gene from each parent for the disease to manifest in a child, who has, then, 2 mutated genes. In most cases, there is no family history of the disease, and the parents do not have the disease themselves but are carriers. (+ info
Does anyone know about polycystic kidney disease?
My husband has just been diagnosed with PKD. We are both devastated and have been petrified by what we have read on the web. He is only 46 and has no symptoms at the moment other than high blood pressure which is being treated. I am so desperately afraid of this diagnosis.
If you want true information about this PKD disease, this is the best site for honest information...
They also have doctor videos on this site to
look at and learn more about this disease.
(If Kidney transplant is in his future...watch the Video here by doctor Robert Montgomery...he is a World Reknown Transplant Surgeon at
Johns Hopkins Hospital in Baltimore, MD.)
There is a group for those who need or may need to have a Kidney transplant...it is free
to join and post; Other here have PKD and
may be able to help you:
Here is a patients guide to kidney transplantation
put out by one of the many Transplant Centers:
You will learn about when a patient may need
a transplant, about his lab tests, and other things
also. (+ info
I have polycystic kidney disease and the pain that comes with it when the kidneys become enlarged.?
I can not take NSAIDS, and dr's give me non-specific narcotic pain meds. While these make my head feel loosy goosy doesn't do much for my pain. I have read its basically nerve pain. is there meds for nerve pain?
I also suffered kidney disease,and have recieved a transplant,the pain you are suffering I feel for you- My Nephrologist didn't have to prescribe me anything due to me having a herniated disc and degenertive spine disease-I was already seeing a pain management doc-If what you are getting isn't working it will be hard to get it out of your Nephrologist due to you are not able to get meds out of your system that easy due to your failing kidneys,but anyway what should work for you is Roxicodone 5mg-these do not have any Tylenol or Asprin in them just a narcotic(Oxycodone-same as Percocet) if you are already on Percocet since you are not sure what it is-look at the bottle,and e-mail me,and I can tell you what may best suit you-you may also e-mail me from this site,and i will give you my real e-mail adress if you need to talk about any issues concerning your kidney failure-been there and I know it's very hard and sometimes frustrating....Are you on Dyalisis yet??? (+ info
What is the best solutions for the polycystic kidney disease kidney enlarge very big?
my dad died from it at 24 years old my sister is in her late fourtys and has it and is very sick in and out of N STAGE hopefully you are going to the right docs and are on the transplant list this is a very dangerous thing little cyst break away and attach to your other organs causing various other illnesses you can contact the national kidney hot line for all the info you need good luck (+ info
Has anyone ever heard of Polycystic Kidney Disease? Is there an effective way to manage the pain?
It appears that no analgesics can be used with impunity. Codeine and other narcotics can lead to dependency or addiction. Non-steroidal anti-inflammatory agents (aspirin, ibuprofen, naproxyn and several more with trade names such as Advil, Nuprin, Naprosyn, Motrin, etc.) can reduce the flow of blood through the kidneys and aggravate high blood pressure - so PKD patients should NOT take these medications. Acetaminophen can probably be used in small doses for short
periods of time without injuring the kidneys, but patients with chronic, severe pain may have to consult a specialized pain clinic in order to consider alternative types of treatment.
There have been some exciting preliminary results in the use of laparoscopic surgery to “unroof” cysts (also called de-roofing) and thereby reduce pain in ADPKD patients. Laparoscopic surgery is similar to arthroscopic surgery in that only a very small incision is necessary for the procedure, and the surgical recovery time and scarring are much reduced. This procedure is conducted only in patients whose symptoms strongly suggest that their pain is caused by the cysts, and who have cysts larger than five millimeters in diameter. This procedure is only to reduce pain, not to preserve kidney function. (+ info
What kinds of kidney diseases are associated with family history?
When I was recently having an ultrasound scan done of my bladder and kidneys, the doctor doing it took a little while looking at my bladder, a little while on my left kidney, then a long time on my right kidney. After looking at the right kidney for some time, he paused and asked whether i have any family history of problems with the kidney, I replied that someone may have had stones at some point but i'm not entirely sure, and he just went quiet which made me think he's not talking about stones, then he continued looking at the kidney some more.
What kinds of kidney diseases are associated with family history?
Diabetes (+ info
How do I take care of myself if I have polycystic kidney disease and also diabetic?
follow your doctor's recommendations, not ours. (+ info
Diseases or damage of the kidney typically result in severe medical conditions. What are some of the more comm
Diseases or damage of the kidney typically result in severe medical conditions. What are some of the more common kidney diseases and ailments? and what parts of the kidney are impacted by the ailment you selected.
Google Kidney disease (+ info
Does anyone have information regarding POLYCYSTIC KIDNEY DISEASE?
What causes it, what are survival chances, where is the gene for it located?????
yea i know what it is but since its YOUR biology homework, im not helping!!!!!!!!!!!!!!!!!!!! (+ info
Which army regulation covers disqualifying conditions for deployment pertaining to Polycystic kidney disease?
My unit is currently on orders for deployment. I'm not afraid to go, I knew there was a chance when I enlisted. I have Autosomol Dominant Polycystic Kidney Disease (ADPKD). I'm just wandering what kind of treatment will be available in Iraq? I was diagnosed with it in 2000. My mom and her siblings have it. My Aunt and Uncle are currently undergoing dyalisys for their ADKPD.
You will have to ask the Army medical staff - if you remind them that you have it they can look up the regs.
It might not disqualify you at all if it's not severe or if the treatment is not complicated. (+ info
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Last update: September 2014