FAQ - Nevus
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can anyone help me i ned gitting informiton in Epidermal Nevus syndrome ane news to haw removedfrom the body?


CAN anyone help me i nid gitting agood doctrs bicus may son have Epidermal Nevus sydrome and he is naw an baad conditon olrerde he was removed bay laissr in UK but steel he not fild good i nid ine new informiton abut ane new midcin for this kind of skin
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Here are a couple of web sites that may help you. They have phone numbers of doctors that can help you.
Good luck,

http://dermatology.cdlib.org/DOJvol7num1/NYUcases/nevus/dosik.html


http://www.webmd.com/hw/health_guide_atoz/nord862.asp?src=Inktomi&condition=healthwise  (+ info)

Any body got treated from conjunctival nevus?? Or got experience in that field?


What exactly do you mean by being "treated" for the nevus? I had mine removed a few months ago. What would like to know about it?  (+ info)

Was there any famous people with Blue Rubber Bleb Nevus Syndrome?


I dont actually know for sure but i would highly doubt it.theres only a few hundred cases worldwide.its very rare  (+ info)

dangers of removal of too much moles/nevus?


Could there be possible hazards/dangers of removing many nevus to avoid melanoma?

I mean it would be better if you removed all dyplastic nevus in your body as a precaution for melanoma protection

However could removing too much moles due any harmful damage?
Or no because your *removed* part of your skin will just repair itself
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Yes of course there are risks involved. This is why it should only be done when it is necessary.  (+ info)

I have just been informed that I have mild dysplastic compound nevus...?


But that they got all the tissue and I need to have the area checked in six months. This is the second mole I have had with this issue.

Should I expect this to continue? Am I a high risk for cancer?
I am not fair skinned and I have avoided tanning for the past seven years. I always wear sunscreen.
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if you are fair skinned and have a lot of moles, yes. Avoid tanning booths like the plague and protect your skin in the sun, minimize exposure as much as you can, always wear a sun screen.  (+ info)

Help! 2 yr old child with epidermal nevus syndrome?


My 2 yr old child has epidermal nevus syndrome. would like to talk with parents who are going through it, and have suggestions. or any place to post and get more answers from parents
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  (+ info)

Have you heard about a skin disease "nevus ota"?


Background: Nevus of Ota, which originally was described by Ota and Tanino in 1939, is a hamartoma of dermal melanocytes. Clinically, nevus of Ota presents as a blue or gray patch on the face, which is congenital or acquired and is within the distribution of the ophthalmic and maxillary branches of the trigeminal nerve. The nevus can be unilateral or bilateral, and, in addition to skin, it may involve the ocular and oral mucosal surfaces.

Nevus of Ito, initially described by Minor Ito in 1954, is a dermal melanocytic condition affecting the shoulder area. Nevus of Ito often occurs in association with nevus of Ota in the same patient but is much less common, although the true incidence is unknown.


Pathophysiology: The etiology and pathogenesis of nevi of Ota and Ito are not known. Although unconfirmed, nevus of Ota and other dermal melanocytic disorders, such as nevus of Ito, blue nevus, and mongolian spots, may represent melanocytes that have not migrated completely from the neural crest to the epidermis during the embryonic stage. The variable prevalence among different populations suggests genetic influences, although familial cases of nevus of Ota are exceedingly rare. The 2 peak ages of onset in early infancy and in early adolescence suggest that hormones are a factor in the development of this condition. The observation of dermal melanocytes in close proximity with nerve bundles in nevus of Ito suggests that the nervous system is a factor in the development of nevus of Ito, although the true pathogenesis remains unknown.


Mortality/Morbidity: Nevus of Ota can cause facial disfigurement, resulting in emotional and psychologic distress. In rare cases, melanoma, which can be life threatening, has been reported to arise from nevus of Ota. Glaucoma also has been associated with nevus of Ota.

Nevus of Ito usually does not have symptoms and causes little cosmetic concern to the patients; however, sensory changes occasionally are present in the lesion.

Race:

Nevi of Ota and Ito occur most frequently in Asian populations, with an estimated prevalence of 0.2-0.6% for nevus of Ota in Japanese persons. Nevus of Ito is less common than nevus of Ota, although true incidence is unknown.
Other ethnic groups with increased prevalence include Africans, African Americans, and East Indians.
Nevi of Ota and Ito are uncommon in whites.
Sex:

Male-to-female ratio is 1:4.8 for nevus of Ota. The ratio for nevus of Ito is unknown.
Age:

The first peak of onset of nevus of Ota occurs in infancy, with as many as 50% of nevus of Ota cases present at birth. The onset for nevus of Ito is at birth or shortly after.
The second peak of onset for nevus of Ota is seen during adolescence.
Isolated cases of delayed-onset nevi of Ota that first appear in adults, including in older patients, have been reported.




CLINICAL Section 3 of 9
Author Information Introduction Clinical Differentials Workup Treatment Follow-up Miscellaneous Bibliography



History: After onset, nevus of Ota may slowly and progressively enlarge and darken in color, and its appearance usually remains stable once adulthood is reached. The color or perception of the color of nevus of Ota may fluctuate according to personal and environmental conditions, such as fatigue, menstruation, insomnia, and cloudy, cold, or hot weather conditions. Nevus of Ota can be associated with other cutaneous disorders and ocular disease. Nevus of Ito can be associated with sensory changes in the involved skin.

Benign cutaneous and leptomeningeal conditions associated with nevus of Ota
Nevus of Ito
Phakomatosis pigmentovascularis
Nevus flammeus
Sturge-Weber syndrome
Neurofibromatosis and leptomeningeal melanosis
Malignant melanoma
More than 60 cases of malignant melanoma (56 in whites, 4 in Japanese) in association with nevus of Ota have been described in the literature as follows:

Skin - 10 cases

Meninges - 12 cases

Ocular tissues - 40 cases
To date, only 1 case of malignant degeneration of nevus of Ito has been described and involved a 78-year-old white man.
Ocular abnormalities (ocular acuity normal)
Pigmentation of the sclera, cornea, retina, and optic disc
Cavernous hemangiomas of the optic disc
Elevated intraocular pressure
Glaucoma (10.3%)
Ocular melanoma
Physical:



Table. Clinical and Histologic Features for Differential Diagnoses of Nevi of Ota and ItoCondition Onset Appearance Location Histology
Nevi of Ota and Ito Birth or early adolescence Blue or gray speckled coalescing macules or patches For nevus of Ota, unilateral, rarely bilateral, on forehead, temple, zygomatic, or periorbital areas; for nevus of Ito, the shoulder and upper arm areas Increased dermal melanocytes, with surrounding fibrosis and melanophages

Mongolian spot Birth Poorly demarcated large blue-to-gray patches that tend to spontaneously resolve by age 3-6 y Most frequently on lumbosacral areas, buttocks, and rarely, other areas Increased dermal melanocytes; no surrounding fibrosis

Blue nevus Congenital or acquired Blue papules or plaques Anywhere on skin Dermal nodular proliferation of heavily pigmented spindle cells

Melasma Acquired; may be associated with pregnancy and other estrogen excess stages Well-to-poorly demarcated and irregularly outlined brown-to-gray brown patches Maxillary and zygomatic areas on face No increase in dermal melanocytes; presence of melanophages

Lentigo maligna Acquired; presenting usually after fifth decade of life Brown patches, usually with pigmentary variegation Photodistribution, particularly within zygomaticomaxillary areas Atypical melanocytes in nests at dermal-epidermal junction, with pagetoid spread

Actinic lentigo Acquired; usually after fifth decade of life Well-demarcated brown papules or plaques Photodistribution, especially on face Elongation of rete ridges; basal layer hyperpigmentation; slight increase of melanocyte number along basal layer

Phytophotodermatitis Acquired; exposure to certain plants or cosmetics Gray-to-brown macules and patches Photodistribution, according to sites of contact with photosensitizer Dermal melanophages

Drug-induced hyperpigmentation Acquired; following drug exposure (eg, minocycline, amiodarone, gold) Variable according to offending drugs Variable according to specific offending drugs Variable but may involve presence of dermal melanophages; pigmentation of basal keratinocytes

Exogenous ochronosis (rare) Adulthood; following topical application of hydroquinone Irregularly shaped blue-to-gray patches or macules Areas corresponding to exposure to hydroquinone Yellow banana-shaped spindle cells in papillary dermis

Ochronosis (alkaptonuria, rare) First decade of life Blue-gray discoloration of ear cartilage, tip of nose, and sclera Symmetrical distribution over cartilage, nose, cheeks, and extensor tendons of hands, as well as flexural areas Yellow-to-brown pigmentary granules within dermal macrophages



Nevus of Ota most frequently presents as blue-to-gray speckled or mottled coalescing macules or patches affecting the forehead, temple, malar area, or periorbital skin. Nevus of Ito presents as a patch on the shoulder or upper arms with blue, gray, or brown pigmentation.
Most cases of nevus of Ota are unilateral (90%), although pigmentation is present bilaterally in 5-10%. Nevus of Ito usually is unilateral.
In addition to skin, pigmentation of nevus of Ota may involve oral mucosa and ocular structures such as the sclera, retrobulbar fat, cornea, and retina.
Clinically, nevus of Ito is similar to nevus of Ota, except that it typically presents over the shoulder girdle region.
Specific variants of nevus of Ota have been described in the literature under the names of nevus fuscoceruleus zygomaticus, plaque-type variant of blue nevus, or Hori nevus. Some clinicians consider Hori nevus to be a distinct entity that is separate from nevus of Ota. Differential features of these conditions are related to the following:
Location of patch or macules
Extent of involvement
Age of onset
Tendency to occur as familial cases
Presence of a papular component
Pathology and response to therapy appear similar for all forms of nevus of Ota. The pathology of nevus of Ito is similar to that of nevus of Ota.
Causes: The cause of nevi of Ota and Ito is unknown.  (+ info)

Hi, i have a nevus at the back of my eye and i,m worried, does anyone else have one.....thank you.?


many people have it but you require frequent check ups to detect early changes of Melanoma which has a higher incidence in this location.  (+ info)

removal of conjunctival nevus on a 4 year old. thoughts...?


My 4 year old has a conjunctival nevus (mark in the white of her eye). It has been there as long as I can remember. In the last year it has grown in size. I have been told this needs removing, day surgery home later in the day. I'm worried about an operation on someone so young on the white of the eye. and the psychological issues, being so young.
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The concern is probably that it has grown. The doctor probably wants to remove it and do a biopsy. This seems like a good idea. Remember that the conjunctiva is the layer of tissue over the sclera so this is really pretty superficial.  (+ info)

I'm nevus when i talk to a girl that i like what should i do?


She goes to a different school.I mostly see her a partys.
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be yourself
make sure u dont stare at her boobs
talk about stuff that both of u like
just do what feels right

if u do what i said everything should come naturauly after that  (+ info)

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