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FAQ - Metaplasia
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i do endoscopy and my doctor?


in report of pathology said that
GASTRIC ANTRUM AND TRANSITION MUCOSA WITH MINIMAL CHRONIC INFLAMMATION ,FOCAL INTESTINAL METAPLASIA AND FOCAL MILD DYSPLASIA
is it means i had cancer????
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elevated levels of IgA (613) but don't have celiac disease. what's wrong with me?


i have idiopathic gastroparesis (delayed gastric emptying with no known cause or trigger) and Hashimoto's thyroiditis (an autoimmune thyroid condition). my gliadin and tTg antibodies were not present and my duodenal biopsy showed norma villi functioning, so i have a conclusive "no" for celiac's disease.... but why is my IgA so high? ref range is 81-463 and mine is 613. this is my biopsy report from april. what does this indicate?

A. Duodenum, biopsy:
Duodenal mucosa with vascular congestion, focal minimal chronic inflammation
and preserved villous architecture.

B. Stomach, antrum, biopsy:
Gastric antral and fundic mucosa with mild chronic inflammation, vascular
congestion and mild reactive fibromuscular and foveolar hyperplasia, suggestive
of mild reactive gastropathy. No H Pylori organisms are seen with routine stain.

C. G.E. Juction, biopsy:
Gastric cardiac and fundic mucosa with edema and vascular congestion.
No intestinal metaplasia seen.
No squamous mucosa present.
yes, i have seen an endocrinologist. i know quite a bit about my gastroparesis and hashimoto's already. my question was more directed at my elevated IgA levels and whether the results of my biopsy could help determine why my IgA is so high.
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Are you seeing an endocrinologist? here is what I found on the net..

Hashimoto’s thyroiditis

http://www.clinicaltrials.gov/ct/search?term=thyroiditis&submit=Search (clinical trials...one with selenium..one with hep c relationship to hashimoto's, one with postpartum link)
http://en.wikipedia.org/wiki/Hashimoto's_thyroiditis (wikipedia)
http://www.nlm.nih.gov/medlineplus/ency/article/000371.htm (medline plus)
http://autoimmune.pathology.jhmi.edu/diseases.cfm?systemID=3&DiseaseID=22 (John Hopkins…hashimoto's thyroiditis is linked to sjorgren’s syndrome)
http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Hypothyroidism (NORD..hypothyroidism…scroll down for related organizations)
http://www.hormone.org/public/thyroid/hypothyroidism.cfm (the hormone foundation)
http://www.thyroid-info.com/hashimotos-encephalopathy.htm (Hashimoto’s encephalopathy…rare)
http://www.thyroid-info.com/articles/yersinia.htm (hashimoto’s and food borne infection,Yersinia enterocolitica infection, via contaminated meats -- especially raw or undercooked products -- poultry, unpasteurized milk and dairy products, seafood -- and particularly oysters -- from sewage-contaminated waters and produce fertilized with raw manure. Foods can also be contaminated by food handlers who have not effectively washed their hands before handling food or utensils used to prepare food. Improper storage can also contribute to contamination.>> stool test that can detect yersinia enterocolitica )
http://www.thyroid-info.com/articles/cohen.htm (hashimoto’s and anergic depression)
http://thyroid.about.com/cs/hypothyroidism/a/hashivshypo.htm (hashimoto’s vs hypothyroidism..what is the difference… In the study of 21 patients with euthyroid Hashimoto's Thyroiditis (normal range TSH, but elevated antibodies), half of the patients were treated with levothyroxine for a year, the other half were not treated. After 1 year of therapy with levothyroxine, the antibody levels and lymphocytes (evidence of inflammation) decreased significantly only in the group receiving the medication. Among the untreated group, the antibody levels rose or remained the same.
The researchers concluded that preventative treatment of normal TSH range patients with Hashimoto's disease reduced the various markers of autoimmune thyroiditis, and speculated that that such treatment might even be able to stop the progression of Hashimoto's disease, or perhaps even prevent development of the hypothyroidism. )
http://thyroid.about.com/cs/hypothyroidism/a/hashivshypo_2.htm (page 2…selenium might help…and calcium with magnesium supplements for nighttime problems)
http://thyroid.about.com/cs/hashimotos/a/encephalopathy.htm (hashimoto’s encephalopathy)
http://thyroid.about.com/od/hypothyroidismhashimotos/a/preventative.htm (treating antibodies when TSH is normal)
http://thyroid.about.com/blcohen.htm (treating anergic depression)



3 books on disease symptoms and treatments

you could also get these books on ebay or amazon or a half price book store. (last two are very similar)..
1.Oxford Handbook of Clinical Medicine
2.Handbook of Diseases (Lippencott)
3.Professional Guide to Diseases (Springhouse)  (+ info)

pls explain this pap result....?


General Categorization: Negative for intraepithelial lesion or malignancy
Epithelial Cell Abnormalities: Not Present
Descriptive Diagnoses:
Atrophy: Not present
Organisms: Coccobacilli
Inflammation: Moderate
Squamous Metaplasia: Not present
Non-epithelial malignant neoplasm: Not present
CHMI: 0/10/90

Comment: No malignant cells identified. Many Neutrophils

Are there any OB there to explain why is there inflammation?What is neutrophils and cocobacilli harmful? Are there possibilities of being infertile?
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It's an abnormal PAP. Neutrophils are one type of white blood cell. When the body is invaded by bacteria (or other foreign organisms), more neutros are produced to help fight infection. That you have an elevated neutro count supports this. Neutro are phagocytes -- that is, they engulf bacteria and literally eat them. White blood cells (WBC) fight infection and you do have one. The culprit is a coccobacillus (one type of bacteria), well actually many coccobacilli. You have a moderate inflammation, may be pelvic inflammatory disease. No cancer identified. Epithelial cells are just skin cells. Untreated PID can lead to sterility. Is this your own PAP or is this a school assignment??? If this were yours, the results would've been explained to you.  (+ info)

Do I still have Barretts Esophagus?


My doctor performed an endoscopy 1 year ago, took 2 biopsies and told me that I had Barretts Esophagus with Intestinal Metaplasia and no Dysphasia. Last week he performed another endoscopy with one biopsy and said that I showed no signs of Barretts Esophagus or Intestinal Metaplasia which relieved me. He seemed perplexed but said I was OK. I still have a hoarse voice at times with burning in my throat. Should I be concerned and is it possible for Barretts Esophagus to go away?
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It could be converted to healthy tissue or malignant .if during that year you was keen to obey your doctor advice up to letter then your fine and maybe this perplexed your doctor for him to find such a patient  (+ info)

My ex was diagnosed with HPV cuz he had 2 warts on his penis...I also went to my doctor to get checked and...?


my doctor said my cervix look abnormal, I had a pap smear done and also a biopsy. The results were this: BENIGN ENDOCERVICAL POLYP WITH FOCAL SQUAMOUS METAPLASIA AND SEVERE ACUTE AND CHRONIC INFLAMMATION. My doc said it was a benign cervical polyp which she already had removed, and that my cervix is healing. She also said that my tests didn't show any signs of HPV but, that doesn't mean I don't have it, she says it might be dormant. She says the only thing I need to do is go back in a month to check if my cervix has healed completely and have pap smears done twice a year. Is there anything else I can do on my own, what can I so the HPV remains dormant if I have it. And anyone else who is a doctor or knows something about HPV can tell me what my results mean? Thanks
I already got the first shot of the HPV vaccine as soon as I found out my ex had HPV
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Your results mean that your have some abnormal growth on your cervix. A lot of times, abnormal growth is caused by infection with high-risk HPV. When women have Pap smears, they aren't testing for HPV directly, but rather symptoms that imply infection with HPV. Analogously, it's like finding tire tracks and knowing that a car has been there.

A _polyp_ is a bud-like growth of new tissue. _Endocervical_ means in your cervix. _Squamous metaplasia_ refers to the unusual growth of flat-cell epithelial tissue that covers your cervix. _Severe acute and chronic inflammation_ means you've got an inflammation that is currently raging and has been raging for quite a long time. Cervical inflammation is often a result of infection (BV, chlamydia, gonorrhea, trichomoniasis).

What you ought to do is get vaccinated with Gardasil if you are under the age of 27. It won't cure any HPV you have now, but it will protect you from future infections if you come in contact with other strains. Even if you have a steady partner, you should always use condoms unless you are trying to conceive (and you should avoid trying to conceive right now because your cervix needs to heal). Do NOT use a drug store vaginal douche because that will aggravate your cervical inflammation. Keep your immune ysstem happy. Live a healthy lifestyle - eat well, exercise, avoid drug use, get enough sleep and cut your stress.  (+ info)

I had a colposcopy and biopsy done two days ago I am soo worried please help?


My appointment for the results is for 5 wks. I am really worried please help. My pap came back with Glandular Cells Atypical Endocervical Cells. Reactive cellular changes associated with squamous cell metaplasia. I just turned 50 and got these results two days before my birthday. I am sooo stressed out and worried, I also suffer from depression and aneixty and had these conditions well in the past, but they are surfacing again and I have no one that understands what I am going through. Dr. is not very responsive, he is very evasive. He says I might have cancer or not, he is not sure. Please help. thanks
I live in Yauco, Puerto Rico.
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Wow. that's a lot to deal with. First take a deep breath. Relax. Nothing you can do right now will change the test results. However, I would think if you were in a serious medical emergency your doctor would pick up the phone and get you in right away. I worked with a girl and they called her and told her to admit herself into the hospital right way. I would also recommend that you become a pest with your doctor. Be aggressive. Call his nurse and tell her how upset you are. Asked for an earlier appointment. Call her every day till you get the answers. Also asked for a copy of all your test results. They will try to tell you all kinds of excuses. But you have a right to have them. Keep them in a file so that in the event you go to another doctor you have the latest set of test results and might avoid having to do them again or wait till the office gets around to sending them. You said that your doctor is not sure? evasive unresponsive. Honey you need a new doctor. Good luck. Don't let this get the best of you.  (+ info)

This is my mother Gastric biopsy report; anybody may please help me interpreting this, is it normal or there i?


Gross Description:
Specimen received fixed in formalin and consists of five grey white fragments of tissue measuring 1 cm in aggregate. Specimen submitted totally in one block.

Microscopic Description:
Section and levels reveal fragments of gastric mucosa lined by benign columnar epithelium. The lamina propria reveals no significant inflammation. There is no evidence of intestinal metaplasia, dysplasia or of malignancy. H. pylori like organisms are not identified.

Microscopic Diagnosis:
Gastric Biopsy: - Normal Gastric Mucosa
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I got pap results. It states ASCUS. What does this mean? What do I expect?


The results read...
EPITHELIAL CELL ABNORMALITY
ATYPICAL SQUAMOUS CELLS OF UNDETERMINED SIGNIFICANCE
I have an IUD in...and was planning to have it removed in 2 weeks as my hubby & I want to try to get pregnant. I am so scared! What does all of this mean? Should I still have IUD removed? Could it have something to do with my results? It says to repeat test in 3 months...Do I really have to wait that long??? I am a WRECK! I have never had an abnormal pap before and I am very scared! It also mentions "HIFT IN FLORA SUGGESTIVE OF BV, REACTIVE CELLULAR CHANGES, SQUAMOUS METAPLASIA, INFLAMMATORY CHANGES, PRTIALL OBSCURING ACUTE INFLAMATION, POOR FIXATION OR PRESERVATION"
WHAT IS ALL OF THIS???? PLEASE HELP!!!
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Ask the physician who obtained the specimen and ordered the Pap. I believe al the YA Gynecologists are off for the holiday weekend.  (+ info)

Got my pap, biopsy and cytology results back, please explain what it means. any obgyn's?


Ok so i already know i have hpv but im really worried about my results. I feel like my doc is not telling me whats really going on.

My results read:

Pap smear: Epitherial cell abnormaty.
Atypical squamous cells of undetermined sig. (asc-us)
High risk hpv is freuquently detected in cervical cancer and its precursors.


Biopsy and cytology read:
CIN 1 (low grade SIL)
Chronic cervicitis and endocervictis with squamous metaplasia.

ENDOCERVIX
Benign endocervical tissue with mucus.
Showing early secretory features.
No tumor, No dysplasia or hyperplasia identified.
But thats the thing he didnt explain what any of this means. I had to ask for copies cause he nver explains the results.
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Pap smear: abnormal cells
Squamous (flat) cells atypical; significance not known
You're at high risk for cervical cancer and precursors

Biopsy & cytology:
CIT 1 = cervical dysplasia (abnormal cell growth/development), level 1, few abnormal cells
Cervicitis is inflammation of the cervix
Endocervicitis is inflammation of the endocervix
Metaplasia is cells being replaced by other cells

Endocervix:
Tissue looks harmless
????
No cancer, abnormal cells or excessive cell growth



Sounds like you need to find a new doctor, one who will sit down and discuss your results with you. You're showing some abnormal cells and inflammation, but are probably going to be fine.

If you have any other questions about what this means, feel free to email me via Answers.  (+ info)

Pathology Readings help! what does this mean?


1 FINAL DIAGNOSIS

Endocervix, curettings - Segments of benign endocervix with focal squamous
metaplasia.
- Negative for neoplasm..
SPECIMEN SUBMITTED
A: ENDOCERVICAL, CURETTINGS


CLINICAL DATA
AGUS PAP


#2 and this:
SPECIMEN SUBMITTED
A: THINPREP PAP ECTOCERVICAL/ENDOCERVICAL (1 OUTSIDE SLIDE C09-15047)

___________________________________________________________________

FINAL DIAGNOSIS
A. THINPREP PAP ECTOCERVICAL/ENDOCERVICAL (1 OUTSIDE SLIDE C09-15047):
Satisfactory for interpretation.
Epithelial cell abnormality.
Atypical glandular cells present, favor endometrial origin.
Atypical squamous cells of undetermined significance (ASC-US).


# 3 and FINALLY, this is the last result:

FINAL DIAGNOSIS

Endometrium, curettage - Exaggerated (disordered) proliferative endometrium
with focal stromal breakdown and changes consistent with anovulation.
SPECIMEN SUBMITTED
A: ENDOMETRIAL, CURETTINGS


CLINICAL DATA
ATYPICAL GLANDULAR CELLS
addition** yes, doctor reviewed this with me, but gave me the whole "everything's okay for now" bit and not much more.
Seeking second opinion, but wanted other info from here too.
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didn't your doc go over all this stuff with ya ?  (+ info)

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