FAQ - Leukemia, Myelomonocytic, Chronic
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A list of what lab equipment is used in Chronic Myelomonocytic Leukemia (CML)?


a list as soon as possible
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The best spot I have found for help on Leukemia is this web site.
http://www.leukemia-lymphoma.org  (+ info)

Anyone being treated for Chronic Myelomonocytic Leukemia (CMML)?


My husband was recently diagnosed with CMML, due to a bone marrow test.(he will be 74 in December). His white cell count was 16000th and went up to 18000th. last test was 16700th.He was told as the result of last test that was normal, but his primary Dr. was concerned when it elevated to 16000th's. What is a normal range?
He is being treated for low platelets. 1 - 1 1/2 years ago they showed up at about 45 (thousandths)...since then he has given up smoking & drinking and regular coffee. The platelet count (last tested)was about 65.
He has none of the symptoms related to CMML (weakness..shortness of breath..anemia..bleeding..bruising..recurrent infections..enlarged spleen)and his hematoligist doesn't seem to be to concerned about it. Saw him last month and he doesn't want to see him for another 3 months.
Hematoligist says platelets can be added to do this procedure,and would probably be an over night stay in the hospital.
Back to original question.What is normal range for White Blood Cells?
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The defining features of CMML are an absolute monocytosis of >1X109/l, increased numbers of monocytes in bone marrow, and a variable degree of dyplasia in all three lineages. Myeloblasts and promonocytes comprise less than 5% of nucleated cells in peripheral blood and less than 20% of cells in bone marrow. Roughly half of patients present with an elevated white cell count that is commonly associated with hepatomegaly and splenomegaly, the so-called myeloproliferative form of the disease. Patients lacking these features are generally considered to have the myelodysplastic form of the disease

Here are a few normal values that you would be interested to learn about:
HEMATOCRIT (HCT)
Normal Adult Female Range: 37 - 47%
Optimal Adult Female Reading: 42%
Normal Adult Male Range 40 - 54%
Optimal Adult Male Reading: 47
Normal Newborn Range: 50 - 62%
Optimal Newborn Reading: 56



HEMOGLOBIN (HGB)
Normal Adult Female Range: 12 - 16 g/dl
Optimal Adult Female Reading: 14 g/dl
Normal Adult Male Range: 14 - 18 g/dl
Optimal Adult Male Reading: 16 g/dl
Normal Newborn Range: 14 - 20 g/dl
Optimal Newborn Reading: 17 g/dl



MCH (Mean Corpuscular Hemoglobin)
Normal Adult Range: 27 - 33 pg
Optimal Adult Reading: 30



MCV (Mean Corpuscular Volume)
Normal Adult Range: 80 - 100 fl
Optimal Adult Reading: 90
Higher ranges are found in newborns and infants



MCHC (Mean Corpuscular Hemoglobin Concentration)
Normal Adult Range: 32 - 36 %
Optimal Adult Reading: 34
Higher ranges are found in newborns and infants


R.B.C. (Red Blood Cell Count)
Normal Adult Female Range: 3.9 - 5.2 mill/mcl
Optimal Adult Female Reading: 4.55
Normal Adult Male Range: 4.2 - 5.6 mill/mcl
Optimal Adult Male Reading: 4.9
Lower ranges are found in Children, newborns and infants


W.B.C. (White Blood Cell Count)
Normal Adult Range: 3.8 - 10.8 thous/mcl
Optimal Adult Reading: 7.3
Higher ranges are found in children, newborns and infants.


PLATELET COUNT
Normal Adult Range: 130 - 400 thous/mcl
Optimal Adult Reading: 265
Higher ranges are found in children, newborns and infants


NEUTROPHILS and NEUTROPHIL COUNT - this is the main defender of the body against infection and antigens. High levels may indicate an active infection.
Normal Adult Range: 48 - 73 %
Optimal Adult Reading: 60.5
Normal Children’s Range: 30 - 60 %
Optimal Children’s Reading: 45


LYMPHOCYTES and LYMPHOCYTE COUNT - Elevated levels may indicate an active viral infections such as measles, rubella, chickenpox, or infectious mononucleosis.
Normal Adult Range: 18 - 48 %
Optimal Adult Reading: 33
Normal Children’s Range: 25 - 50 %
Optimal Children’s Reading: 37.5  (+ info)

Does anyone have or know anything about Chronic myelomonocytic leukemia?


My mother was diagnosed approx 8 months ago after about 12 months of trying to get answers. She is 65years old and has a blood count of (not sure which blood cells) 45 it fluctuates and she has a vitamin B shot every month. No one has told us or her anything I only got the actual name of it last night whenever she asked she was fobbed off and told it was to long to write what a load of crock. I have no idea of life expectancy except the professor said he has had patients live approx 5-6 years is there really 3 stages to this? We have been given no information by hospital and twice she was referred by her GP to get a blood transfution and twice said to take a panadol for the pain and sent home. What should we expect ?? She also has Vanswillansbrand disease (not sure of the spelling) they also dispute this even though she was one of the original people it was diagnosed of 35 years ago. She has recently also been havign problems with her bowels and nose not sure if it's related.
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I'll be a third voice here.

There are huge differences in prognosis and treatment between the various types of leukemia. Be SURE that you know exactlly which one you are talking about.

CMML (chronis myelomonocitic leukemia) is variety somewhre inbetween AML (which Midnight had) and CML (see below).

CML (chronic myelogenous leukemia) is a more common form. Once upon a time the only real treatment for it was a bone marrow (stem cell) transplant. Now Gleevec is on the market and controlling the disease for years at a time with relatively minor side effects.

If your mom is open to your help, or asking for your help, my advice is:
1. Make sure of which one you are dealing with.
2. Schedule an appt. with her doc. Either go with her or help her to make a list of questions.
Include the following:
A. What is the diagnosis. Ask for a copy of the pathology report.
B. What is the prognosis?
C. What treatments are recommended. Why does the doctor recommend this course of action as opposed to something else? (Why chemo instead of waiting? Why waiting instead of chemo? etc.)
D. What will he monitor to determine her response? What tests need to be done on a regular basis?
E. What is the next step if she doesn't respond or if the disease progresses?

3. If her doctor is not willing or able to answer these questions then it is time to get a new doctor.
4. Then get a second opinion from a hematologist in another medical center. CMML is hard to treat, and she may be eligible for clinical trials.

Here is a link to CMML on the LLS website:
http://www.leukemia-lymphoma.org/all_mat_toc.adp?item_id=69974

Best of luck to you both.

MM

PS: The '45' might also represent a high white count, (short for 45,000) which is often seen in CMML  (+ info)

What is acute lymphocytic leukemia in a chronic stage?


A friend was recently diagnosed with acute lymphocytic leukemia but said that hopefully it'll be in a chronic stage. I have no idea what any of this means. I went online and was doing a little research but it said it effected mostly older people, and he's only twenty. I couldn't find anything on what treatment entails or what chronic stage means. Anyone deal with this on a first hand experience? Is a chronic stage good?
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Acute Lymphocytic Leukemia (ALL)

There are four major types of leukemia. ALL is the most common type of leukemia diagnosed in children, and the least common type diagnosed in adults. About 5,200 people are diagnosed with ALL each year. Children account for two-thirds of these cases. In general, children with ALL have a better prognosis than adults. Most children with ALL can be cured of this cancer.
Symptoms of ALL include fatigue, pale skin, recurrent infections, bone pain, bruising, and small red spots under the skin. Doctors use various tests, including blood counts and bone marrow biopsies, to diagnose ALL.ALL is treated with chemotherapy and, sometimes, radiation. Children receive different types of chemotherapy regimens than adults. Patients with advanced cancer that has not responded to these treatments may need a stem cell transplant.  (+ info)

What are the chances of a 78 year old beating chronic leukemia?


My grandma is in pretty good health for being 78, she had a bi-pass surgery about 6 years ago and is an active woman.

She recently had a lot pain in her leg and went to the doctor, they took a biopsy of her bone marrow and informed her that she has chronic leukemia.

She is taking medications and chemo that is costing $3000 a month. She honestly believes she is not going to make it.

What are the chances she will beat the leukemia at her age?

I knew two people her age with leukemia and both of them died within a year even though they had top of the line doctors. I am feeling pretty hopeless!
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I knoe of a 70 year old man in Austin Texas who owns the Armstrong supply houses who is in medical journal for surviving lukiemia. Hes alive and well and everyone thought he'd die. Just ask for AJ and go to the one on Anderson Lane. They will ask you if you have a license but just say you want to talk to him about lukeimia  (+ info)

What happens when a bone marrow transplant is needed for chronic myeloid leukemia?


My mother may have chronic myeloid leukemia, and one of the ways of treating it is a bone marrow transplant.

Who are usually the closest matches for donors? Can children be a close enough match (usually) to be a donor?

Once a donor is found, what happens?

I am very worried, and would like to know what my chances are of being able to help my mother. I would like to know what may be in store for her, and how I can help her prepare in every way. I would also like to know how the transplant affects the donor so I may prepare, if I am a match.

Thanks for any help.
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There is a non invasive way to treat CML (chronic myeloid leukemia). This is with the use of a drug called Gleevac (Imantinib). This drug targets the receptors on the CML cells and prevents them from dividing.

CML occurs as a result of a translocation of a chromosome to produce a new chromosome called the philedelphia chromosome and to produce a active protein called BCR/abl. This is a tyrosine kinase receptor which actively stimulates cells to divide uncontrollably. Gleevac targets the receptor specifically and stops the cell division.

Good luck!  (+ info)

I am seeking information on ways to reduce white cell counts in Chronic Lymphatic Leukemia?


are there any herbals.naturopathic,mineral suggestions in assisting the reduction of white cell count for Chronic Lymphatic Leukemia?
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Pranayam will help to reduce the white cell count in chronic lymphatic leukemia and will help the body to fight the cancer.Over long term you will recover fully.
The pranayam techniques:
Bhastrika - Take a long deep breath into the lungs(chest not tummy) via the nose and then completely breathe out through the nose.Duration upto 5 minutes.

Kapalbhati -(Do it before eating) Push air forcefully out through the nose about once per second. Stomach will itself go in(contract in). The breathing in(through the nose) will happen automatically. Establish a rhythm and do for 20 to 30 minutes twice a day.(Max 60 min/day) Not for pregnant women. Seriously ill people do it gently.

Anulom Vilom - Close your right nostril with thumb and deep breath-in through left nostril
then – close left nostril with two fingers and breath-out through right nostril
then -keeping the left nostril closed deep breath-in through right nostril
then - close your right nostril with thumb and breath-out through left nostril.
This is one cycle of anulom vilom.
Repeat this cycle for 20 to 30 minutes twice a day(maximum 60 minutes in one day).
You can do this before breakfast/lunch/dinner or before bedtime or in bed.Remember to take deep long breaths into the lungs.You can do this while sitting on floor or chair or lying in bed.

Bhramri Pranayam -Close eyes. Close ears with thumb, index finger on forehead, and rest three fingers on base of nose touching eyes. Breathe in through nose. And now breathe out through nose while humming like a bee.
Duration : 5 to 10 times

Only by doing you will benefit and will feel good that you can do something to help the body.Copy and print this to improve your technique and stay focused.This is simplified pranayam for everyone and you do not have to go to classes to learn. This is for life, unlike short term classes where you do it in the class then stop when classes are over.  (+ info)

What is the difference between acute leukemia and chronic leukemia?


If can also include a description on AML, CML, ALL, CLL leukemia
This is for my holiday homework.
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Go to webmd.com  (+ info)

What are the percentages of people with adult chronic leukemia going into remission?


Chronic adult leukemia survival rate.
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Here's a website with that information. Scroll down towards the bottom of the page and read under "Survival"

The site is a great place for all kinds of information about leukemia. It's great that you're doing research and getting the facts.

http://www.leukemia-lymphoma.org/all_page.adp?item_id=9346  (+ info)

what are the problems that arise when a person with Chronic Myelogenous Leukemia (CML) becomes pregnant?


I want to know whhat are the risks and problems faced when someone with Chronic Myelogenous Leukemia (CML) is pregnant? what are the chances of survival of mother and or child? will the child be born with or without medical defects (will the clid also have Chronic Myelogenous Leukemia (CML))?

I need to know because my sister has this illness and is 4 months pregnant..
Please do help.
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Last update: September 2014