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FAQ - Leukemia, Myeloid, Chronic
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I have just been diagosed with chronic myelogenous leukemia.?


I have just been diagosed with chronic myelogenous leukemia. I also just had a baby 3 weeks ago. What are the chances that she that or a similar bleeding disorder?
I have not been exposed to any radiation. It actually came from a previous diagnosis, or perhaps a mis diagnosis (?) of Disseminated Intravascular Coagulation (DIC) a blood disorder that has some of the same symptoms and the potential to go into a form of leukemia if it is not treated or incorrectly treated.
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CML is NOT hereditary; it is an acquired problem. Historically it was difficult to control long-term, as it transformed into acute leukemia (blast crisis). Currently, a new class of drugs (tyrosine kinase inhibitors) have transformed the treatment; most patients are placed into a molecular remission by one of these drugs, meaning that to the best of our ability we cannot detect evidence for the disease. Does it mean cure? Not sure yet, but maybe for some, or at least control of the disease for a long time(? for life, like high blood pressure- it is not cured, it is controlled).

Acai berries have shown no such benefit as quoted above. They may taste good (or maybe not), but please don't put your faith in only that.

DIC did not lead to or cause this; it is possible DIC could be caused by CML or its complications however. Given the way these drugs have transformed the care of CML patients, it is a time to be optimistic about future treatment and expectations.

God bless, best wishes  (+ info)

What is the genotype of chronic myelogenous leukemia?


I need to know whether CML is a recessive or dominant, autosomal or sex-linked disease.
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CML is due to an altered tyrosine kinase, bcr-abl, created by the fusion of parts of chromosomes 9 and 22. It is not inheritable, or at least no documented proof of inheritance. The damaged chromosomes are not present in the gametes or sex cells. Therefore, it is not dominant or recessive in the sense those terms are used. It does involve autosomal chromosomes, not the sex chromosomes, however.

Blessings  (+ info)

Life expectancy for a 20 year old with chronic myeloid leukaemia?


How long would a 20 year old male (otherwise healthy) have to live if diagnosed with chronic myeloid leukaemia and was opted to not get treatment?
advanced stage CML
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Depends on how far advanced they are.

"Prior to the introduction of imatinib, CML was a life-threatening disease with a median life expectancy of around six to seven years, the only exception being the minority of patients who could receive a stem cell transplant. In most cases, it is now a chronic condition with good quality of life and it is expected that at least three out of four patients will be alive at ten years and overall survival may be even higher than this.Prior to imatinib, CML used to progress slowly during the chronic phase of the disease. This phase lasted four to six years on average and then underwent a transformation to a more rapidly progressing state. In about two-thirds of patients this change was to an accelerated phase, which lasted about three to nine months. This then proceeded to a final or blast phase. In some patients the disease proceeded directly from chronic phase to blast phase. The term "advanced phase" is sometimes used to describe both the accelerated phase and blast phase. There are two distinct types of blast phases defined by the types of blast cells present. In most patients the blast cells (immature white cells) resemble those seen in acute myeloid leukaemia (AML) whereas in about a quarter of patients, the blast cells look more like those seen in acute lymphoblastic leukaemia (ALL). This latter form of the disease is known as lymphoid blast crisis and tends to have a poorer response to treatment."

http://www.lrf.org.uk/en/1/infdispatcml.html


Re: Additional details:

It is not possible to say with any accuracy without knowing the patient's history and haematological picture. However, with treatment, their median duration of survival would normally be around 8 months. Without treatment considerably less. For factors affecting duration of survival, see this paper:

http://www.bloodjournal.org/cgi/reprint/99/7/2304.pdf  (+ info)

What are the symptones of chronic leukemia? Will feel very sick if i have it?


Does ppl with cancer feel sick? or they feel sick because of the treatment? is it cancer itself that cause the sickness?
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You could feel sick - or you could feel absolutely nothing at all. Leukemia is a form of cancer; it has to do with the bone marrow and how it makes the cells that are in your blood. If you are truly concerned about this, see your doctor. It CAN be treated very successfully.  (+ info)

can you have a baby if you have acute myeloid leukemia?


Will it be a high risk pregnancy or would the baby not be affected?
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You mean pregnant with AML now? If so, then if less than 12 weeks, usually if patient does not terminate pregnancy there would be a very high risk of defects or more likely early spontaneous abortion due to toxicity of chemotherapy to fetus. If after 12 weeks, then chance for defects much lower if chemo given, but risk for complications remains higher than average (prematurity, low weight, miscarriage).

If you had AML previously, then your child overwhelmingly likely will be fine. There are very rare AML hereditary syndromes, but these are extremely rare. Biggest trouble can be just getting pregnant in the first place for patients.

God bless, best wishes  (+ info)

How long can someone live with chronic myelgenous leukemia?


Will going on medicine stop the progression of this type of leukemia
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Varies from patient to patient. Since 2002 > 80% patients on Imatinib are living free of disease and without progression. Also percentage of patients moving into progression is also decreasing with time. This is the picture as a whole. It is difficult to comment about an individual. If he/she has achieved CMR/ CCR ( no trace of BCR-ABL or Ph chromosome by RT-PCR or Karyotyping) there is > 80% chance that he will continue to be in remission for > 5 years and may be > 20 years!!! Some acquire newer mutations or chromsomal aberrations that lead to a drug refractory form of disease and the disease relapse. These patients may benefit from newer drugs( most in trial) or in worst case should consider matched unrelated donor stem cell transplantation if feasible.  (+ info)

what is chronic myeloid leukaemia and thier medications?


where do you get chronic myeloid leukaemia from?
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Chronic myeloid leukemia (CML) is a cancer of blood cells, characterized by replacement of the bone marrow with malignant, leukemic cells. Many of these leukemic cells can be found circulating in the blood and can cause enlargement of the spleen, liver, and other organs. CML is usually diagnosed by finding a specific chromosomal abnormality called the Philadelphia (Ph) chromosome (see figure), named after the city where it was first recorded. The Ph chromosome is the result of a translocationor exchange of genetic materialbetween the long arms of chromosomes 9 and 22 .  (+ info)

My daughter was just diagnosed with Acute Myeloid Leukemia?


How Do I cope with this, she was complaining about being sick, I feel like its my fault. She was complaining about not feeling good, then she was diagnosed. I know it's not my fault that she got this but, still. How do I cope?
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You'll find your own routine. At first it's pure shock, Leukemia is the last thing from most parents minds, and its certainly the last thing you wanted to hear. If every parents first thought when their child was sick was "LEUKEMIA" the oncology departments would be in disarray.

When something like this happens, first instinct is to find someone to blame, often people blame the doctors or themselves for not spotting it sooner, usually, this couldn't be further from the truth.

Make sure you keep thinking positively, i'm not sure how old your daughter is, but i'd try not to keep things from her, kids with cancer spend a lot of time thinking about things, they end up far more mature for their age than they might have been otherwise.

I'll bet you and your family will be amazed at how much strength you'll give each other at this time, it's hard now, but keep fighting and you'll do it.

A few hours ago, 30 odd people stood in the playroom of this hospital corridor and sang, cheered and cried, because an 13 year old girl, who'd been fighting Acute Myeloid Leukemia since she was 10 years old has been declared cancer free. And it happens all the time.

Kids are tough, i didn't think my daughter was strong enough to beat this, btu she's doing it. And i bet yours will too.

Best wishes, god bless.  (+ info)

If I have Chronic Myelogenous Leukemia and its in recession, can I still get a tattoo?


I started a tattoo before I got diagnosed and I would like to get it finished.
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You should be fine, as long as you are in *remission* and they use sterile technique. However you are assuming some risk of course by having someone stick you with a hypodermic needle, such as hepatitis, AIDs, other blood-borne communicable diseases. Risk is small but real.

Interestingly, prior studies have shown that the white blood cells which fight infection in patients with chronic-phase CML are rather hyperactive.  (+ info)

My dad was diagnosed with acute myeloid leukemia, we are considering chemo and stem cell, which one is better?


He is treated in a Hospital in Australia at the moment.. any suggestion?
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