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FAQ - Leiomyosarcoma
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What is the life expectancy of someone with metastasized leiomyosarcoma cancer?


I had uterine cancer about 2 years ago. I had a total hysterectomy. Now in January I was diagnosed with the cancer in my lungs. 2 of the tumors were a little bigger than 2 cm. with multiple tumors in both lungs. Now with 18 weeks of chemo the 2 larger tumors have shrunk to about 60 percent. What is my life expectancy?
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God can help you live a better life if you want Him to help you. You can have a personal relationship with God by saying the prayer below. God is our Creator, all-knowing, all-powerful, eternal, holy, love. God loves us and sent us His Son, Jesus Christ, so we can go to heaven if we know and follow Him. Forever means without end -- time on and on without death. Forever is what happens after we die. Either we go to heaven and be with God forever, or we go to hell which is very bad and painful forever. The good people who are saved believers in Jesus Christ go to heaven. The bad people go to hell. We need to know and follow God in this world to get to heaven in the next world. We follow God by loving and obeying Him and loving others for Him. Jesus Christ, God's Son, is our bridge to God. Jesus died on the cross to cancel our sins. We need to accept Jesus into our life as our Lord and Savior forever to receive God's blessing and forgiveness plus go to heaven to be with God forever after we die. This is about being a born-again Christian. Faith in God is a gift from God. You can pray for faith in God. Just speak out and ask God for the faith to believe in Him and to follow Him. Some people find faith in God when they realize the beauty in the world is made by God. Evolution can't explain the world's natural beauty, for example, the parks in the world, animals, flowers, peacocks, sunsets, butterflies, rainbows, etc. After you have your faith on, you can pray a sinner's prayer to be a born-again Christian. This prayer is very important and should be said with a sincere heart and faith in God. This is the prayer: "Dear God, I know that I am a sinner and that Jesus Christ is the sacrifice for our sins. I have done the following sins (state these out) and I pray to discontinue these sins. I pray to receive Jesus Christ into my life as my Lord and Savior forever. In Jesus' name, amen." I'm Lutheran and I like the Baptist churches. You could find a good Christian church and try a weekly Bible study group with them to learn more. You can pray to God about your daily life. God bless.  (+ info)

What is the survival rate of leiomyosarcoma cancer?


Specifically, what are the survival rates in stage three? In addition, how long does it take for it to be fatal?
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Leiomyosarcoma is a type of soft tissue sarcoma.
Most people get leiomyosarcomas in their sixties and seventies although some get it in their thirties. Sometimes children get them too.

Leiomyosarcomas seem to attack both males and females equally, although leiomyosarcomas in females are often uterine.Some persons with leiomyosarcoma have been found to have evidence of Epstein Barr virus or von Recklinghausen's disease.There is no clear evidence of what causes leiomyosarcoma, although some researchers hypothesize a correlation to radiation or certain chemicals used in pesticides and wood preservatives.

Cancer is dangerous because it can spread and invade healthy organs. Cancer can spread by direct invasion of surrounding structures or implanting cells in distant membranes. Leiomyosarcoma very rarely spreads to the lymphatic system.

It is important to remember that every case is different. Leiomyosarcoma is a rare cancer, making the statistical analysis a relatively less consistent indication of an individual's chances of cure and/or remission. There are many factors that contribute to a cancer victim's response to disease and its treatment.

Many things affect reported survival rates. Do not consider survival rates to be your "chances." Individual cases vary too much to think that way. -  (+ info)

I am looking for the name of a condition in uterus which is neither a fibroid nor a leiomyosarcoma.?


It is a fast growing mass / fibroid look alike but apparently there is a condition that is not a fibroid and not cancerous yet? Any ideas? Thanks.
Thanks for responding but it is in between a fibroid and leiomyosarcoma. The conditioin is not a cyst or endometriosis... It is a fast growing mass but not fibroid and not leiomyosarcoma! That is all i know. Thanks.
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  (+ info)

Does anyone know anything about leiomyosarcoma?


My mom was recently diagnosed with leiomyosarcoma after a lump in her breast was biopsied. She had it removed and before she starts radiation therapy, she was sent for a CT scan. It was all clear except for some spots on her liver. According to the doctor these were normally not malignant and she said they would do a follow up CT scan in a couple of months. Does this seem odd? I mean, shouldn't they biopsy the spots now just to be sure. Her cancer is slow growing, but if these spots were malignant it seems it would be better to know now. If you've had any experience with this disease please respond. This has been very hard to deal with and I need any advice I can get.
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Leiomyosarcoma [LMS] is a rare cancer..Leiomyosarcoma is a rare soft tissue cancer. The reports I've seen say that it occurs in about 4 out of a million people; about half of those have it in the extremeties. I've been told that it is incurable, since it can reoccur after the cancer is removed."A leiomyoma (lie-oh-my-OH-mah) is a benign tumor that originates from smooth muscle cells. The body's muscular system is composed of both smooth and striated muscle cells. This distinction is based on the microscopic appearance of the cells. Striated muscles are under voluntary control and are used in such activities as walking and moving your arms. Smooth muscles are not under voluntary control and are in locations such as the wall of the intestine and uterus. They also are in some of the valves (sphincters) of your body, such as those that control the flow of bile into your intestine.

Tumors that arise from smooth muscle cells are most common in the wall of the uterus, where they are better known as uterine fibroids. Less often, leiomyomas occur in the wall of the stomach or
intestine and in the skin, where they arise from tiny muscles in the hair follicles that control the erection of hair and cause goose-flesh when you're exposed to cold.

Malignant tumors of smooth muscle origin are called leiomyosarcomas. They rarely arise from benign fibroid tumors of the uterus or leiomyomas of the stomach or intestine."
Treatements vary from case to case, what works for one person may or may not work for someone else. Because of the rarity of the disease, not much is known about treatments. I've heard of the following methods used to treat LMS, you can ask your doctor about which of these might work on you:

chemotherapy
MAID (Mesna, Adriamyacin, Ifosfamide, DTIC) usually given in the hospital over a period of three or four days
Gemcitabine (Gemzar)
Thalidomide
Vitaxin (in clinical trial stage)
surgery
radiation
radio frequency embolization
cryosurgery
alternative cures  (+ info)

how bad is a combination of Leukemia and leiomyosarcoma?


someone i know may have been diagnosed with a combination of these two. he's 19 years old and maintains a very healthy lifestyle..
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It's rare but happens.

Where is the leiomyosarcoma located? Size? Stage?

Survival from this rare combination would depend on the type of leukemia and the location of the leiomyosarcoma. It's rare that they occur at the same time. Usually the patient has an earlier childhood cancer and the prior treatment is associated with developing another cancer.

Good luck to your friend.  (+ info)

Is there any treatment for Leiomyosarcoma anywhere in the world?


The National LeioMyoSarcoma Foundation has a list of treatment centers http://www.nlmsf.org/
  (+ info)

Does anyone know any info about a type of uterine cancer called leiomyosarcoma?


All cancers start from one particular cell that mutates. Its DNA is damaged by mutations and changes so that the cell no longer grows in an orderly fashion according to the rules for its type. The cancer is often named for the cell type that it grows from but sometimes it has other names.

Soft tissue sarcomas are cancers in which wildly growing (called malignant or cancerous) cells are from a soft tissue part of the body. The soft tissues of the body include fat, blood vessels, nerves, muscles, skin, and cartilage.

Bone is not soft tissue. If the sarcoma grows from bone cells, it is called an osteosarcoma.

You have essentially two kinds of muscle in your body, voluntary and involuntary.

Striated [striped] muscle cells makes up the voluntary muscles; the biceps, triceps, abs, pecs...all the muscles that you can use as you wish by thinking about them. A cancer growing from this kind of cell is a rhabdomyosarcoma.

Leiomyosarcoma is a cancer of smooth muscle cells.

Smooth muscle cells make up the involuntary muscles, which are found in most parts of the body: in uterus, stomach and intestines, walls of all blood vessels, skin [the muscles that give you 'goose bumps']. This muscle is involuntary muscle, you cannot make these muscles move by thinking about them.

GISTs [GastroIntestinal Stromal Tumors] are a special kind of tumor, that used to be considered a kind of Leiomyosarcoma, coming from a particular smooth muscle cell in the stomach/small intestine. We mention these first and separately because there has been a dramatically good advance in treating some of these tumors with a new designer drug. See the separate page on GIST tumors and Glivec/Gleevec. Any GastroIntestinal "sarcoma" or GI LMS should be tested for CD 117 [also called Ckits] protein by an experienced laboratory. This is potentially life-saving information.

Uterine LMS comes from the smooth muscle in the muscle layer of the uterus. Cutaneous LMS comes from the pilo erector muscles in the skin.
GI LMS might come from smooth muscle in the GI tract or, alternatively, also from a blood vessel. At most other primary sites, retroperitoneal [in the abdomen, behind the intestines], extremity, truncal, abdominal organs and so on, the LMS probably grows from the muscle layer of a blood vessel. These blood vessels are everywhere throughout your body, so LMS COULD have a primary site ANYWHERE in your body where there is a blood vessel.  (+ info)

does anyone have any recommendations for the treatment of leiomyosarcoma?


The cancer has metastized to my lungs and my oncologist is not proposing any treatment at this stage. can anyone offer suggestions or know of what treatments are available
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Usually the treatment for metastatic leiomyosarcoma(LMS) is chemotherapy, but it could be targeted molecular therapy, antiangiogenesis cocktails, vaccine, or immuno- or viro- therapy. Currently, chemotherapy is the most effective method available for LMS, but those with more chemoresistant tumors should investigate other treatments.
The key is to seek opinions and helps from a place or oncologist who has experience in treating sarcoma. You may have to travel to a center or some centers if you can to see which one you are comfortable with. It would nice if it is not too far of course.
Best of luck and take care.  (+ info)

how long does it take for a seed from leiomyosarcoma to show up in other parts of body?


on a bone scan
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Hi, your question is impossible to answer. Some LMS cells can travel through the blood, and some will lodge themselves into other organs (mostly lungs) but then lay dormant for a long time. Once it creates a blood supply (a process called angiogenesis) then the cells grow into a tumor. In LMS, it can lay dormant years! And sometimes people never see it again! We have a free online group for LMS with over 400 people on it. If you join, you will get a better picture by looking at everyone's situation and how long before it came back or not.

ACOR L-M-Sarcoma
http://listserv.acor.org/archives/l-m-sarcoma.html

Hope this helps,

Sharon Anderson, MSW
8 yr. stage IV, ULMS survivor,
Executive Director, LMSarcoma Direct Research Foundation www.lmsdr.org
.... Working not Wishing ......  (+ info)

can anyone tell me about leiomyosarcoma?


My mum has recentley been diagnosed has having Leiomyosarcoma in her breast. I believe the condition is rare and i am hoping someone on here can give me some more information, maybe someone with the same condition can get in touch and tell me what to expect. thanks
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Leiomyosarcoma is cancer that consists of smooth muscle cells and small cell sarcoma tumor. The cancer begins in smooth muscle cells that grow uncontrollably and form tumors.Leiomyosarcomas can start in any organ that contains smooth muscle, but can be found in the walls of the stomach, large and small intestines, esophagus, uterus, or deep within the abdomen (retroperitoneal). But for perspective, smooth muscle cancers are quite rare: Less than 1% of all cancers are leiomyosarcomas. Very rarely, leiomyosarcomas begin in blood vessels or in the skin.Most leiomyosarcomas are in the stomach. The second most common site is the small bowel, followed by the colon, rectum, and esophagus.
Leiomyosarcomas do occur in the breast and uterus, but they are very rare. Uterine sarcomas comprise less than 1% of gynecological malignancies and 2% to 5% of all uterine malignancies. Of these numbers, leiomyosarcomas are found in only 0.1% of women of childbearing age who have tumors of the uterus. Less than 2% of tumors in women over age 60 who are undergoing hysterectomy are leiomyosarcomas.

The exact causes of leiomyosarcoma are not known, but there are genetic and environmental risk factors associated with it. Certain inherited conditions that run in families may increase the risk of developing leiomyosarcoma. High-dose radiation exposure, such as radiotherapy used to treat other types of cancer, has also been linked to leiomyosarcoma. It is possible that exposure to certain chemical herbicides may increase the risk of developing sarcomas, but this association has not been proven.
Causes and symptoms -
Since leiomyosarcoma can occur in any location, the symptoms are different and depend on the site of the tumor. When leiomyosarcoma begins in an organ in the abdomen, such as the stomach or small bowel, the physician may be able to feel a large lump or mass when he examines the abdomen. When leiomyosarcoma affects a blood vessel, it may block the flow of blood to the body part supplied by the artery. Commonly occurring symptoms include:

- painless lump or mass
- painful swelling
- abdominal pain
- weight loss
- nausea and vomiting

DIAGNOSIS

Depending on the location of the tumor, the doctor may order imaging studies such as x ray, computed tomography (CT) scan, and magnetic resonance imaging (MRI) to help determine the size, shape, and exact location of the tumor. A biopsy of the tumor is necessary to make the definitive diagnosis of leiomyosarcoma. The tissue sample is examined by a pathologist (specialist in the study of diseased tissue).

Treatment

Treatment for leiomyosarcoma varies depending on the location of the tumor, its size and grade, and the extent of its spread. Treatment planning also takes into account the patient's age, medical history, and general health.

Leiomyosarcomas on the arms and legs may be treated by amputation (removal of the affected limb) or by limb-sparing surgery to remove the tumor. These tumors may also be treated with radiation therapy, chemotherapy, or a combination of both.

Generally, tumors inside the abdomen are surgically removed. The site, size, and extent of the tumor determine the type of surgery performed. Leiomyosarcomas of organs in the abdomen may also be treated with radiation and chemotherapy-.  (+ info)

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