androgen insensitivity syndrome?
for anyone who knows anything about it, do you think i'm a candidate? here's how it is, a couple years ago i got blood drawings to see how much testosterone i had, and i had 40. my doctor said it was abnormally low. i got those tests between 12 and 13 years old. the endocronologist i saw at the time was saying i needed testosterone injections, but i'm a mtf transgender, so i refused them. right now, i'm seeking hormone replacement therapy, and i'm almost 17. my new endocronologist got faxed my new blood test results, and apparently my testosterone is in the normal range suddenly after 4 years. the thing is, i have a femenine face structure, a femenine body shape. i have wide hips, a smaller waist, and little breast mounds. i store fat in my thigh and hips mostly. my voice is femenine, and i have low muscle strength. i'm normal height for my age, tall actually, 5'10 1/2. the only thing that has been going on is hair. i even have some facial hair, but not much. do you think i have something going on like that?
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If it was simply delayed puberty, you wouldn't have developed features that were clearly adult feminine in nature. Perhaps you need to have some further tests run. AIS can take form in both female and male bodied people, and people who are XY/ have clearly male genitalia can still have very feminine secondary sex characteristics.
It isn't unheard of for transgendered people to have some kind of physiological intersex condition. (
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What is the criteria for Partial Androgen Insensitivity Syndrome?
What is the criteria for Partial Androgen Insensitivity Syndrome?
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Androgen insensitivity syndrome (AIS) is typically characterized by evidence of feminization (i.e., undermasculinization) of the external genitalia at birth, abnormal secondary sexual development in puberty, and infertility in individuals with a 46,XY karyotype. AIS represents a spectrum of defects in androgen action and can be subdivided into three broad phenotypes: complete androgen insensitivity syndrome (CAIS), with typical female genitalia; partial androgen insensitivity syndrome (PAIS) with predominantly female, predominantly male, or ambiguous genitalia; and mild androgen insensitivity syndrome (MAIS) with typical male genitalia.
Androgen insensitivity syndrome (AIS) can be subdivided into three phenotypes: complete androgen insensitivity syndrome (CAIS), partial androgen insensitivity syndrome (PAIS), and mild androgen insensitivity syndrome (MAIS) (Table 1).
The clinical findings that permit a presumptive diagnosis of AIS include the following:
Absence of extragenital abnormalities
Two nondysplastic testes
Absent or rudimentary müllerian structures (i.e., fallopian tubes, uterus, and cervix) and the presence of a short vagina
Undermasculinization of the external genitalia at birth
Impaired spermatogenesis and/or somatic virilization at puberty (
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Does anyone have Androgen Insensitivity Syndrome?
I have recently been diagnosed with A.I.S. (Well actually my parents knew but they did not tell me until recently) I was just wondering if anyone out there has A.I.S. If you do not know I have partial A.I.S and was born with testes, that were removed at birth. Have no ovaries, vagina, or uterus. I really need someone with A.I.S to answer this, so I do not feel like such a freak. I am very depressed right now, so I would prefer all ignorance to go away to those answering this question.
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I have complete AIS. Feel free to e-mail me if you want to chat. I know it can be very scary at first. But over time, at least in my instance, I was able to accept it and continue on to live a normal and happy life. Best of luck to you! (
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What is Androgen Insensitivity Syndrome in simple words?
Male sex hormones like testosterone rule the development of the male reproductive system. Testosterone is what makes men go through puberty, produce viable sperm, and many other things. People with Androgen Insensitivity Syndrome are male in their DNA. (This means they have an X and a Y chromosome. Women have two X chromosomes.) But their bodies cannot "hear" sex hormones like testosterone "talking" to them. Even though they may make testosterone, it doesn't work for some reason. It is like a TV whose remote is not working. You are pushing the "on" button on the remote, but the TV won't turn on because for some reason it can't read the signal. Therefore people who have Androgen Insensitivity Syndrome may not have male genitalia because Testosterone is what tells the body to make male genitalia, they are not fertile because their body isn't hearing the testosterone telling it to make sperm, etc. etc. I hope that helps. :) (
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Why cant people with Androgen Insensitivity Syndrome (AIS) process testosterone?
are they technically men are women?
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From a genetic standpoint, they are men (XY karyotype). They present, however, as women (in Complete Androgen Insensitivity Syndrome). There are variations, in which there is partial development of both male and female primary sexual characteristics...which in laymen's terms, is what people consider a "hermaphrodite."
They cannot process testosterone because there is a mutation in the receptor protein that binds the androgens (sex hormones) to the DNA. For the first several weeks of life (in utero), all humans are "female". There is a special gene (SRY) that triggers the development of genitalia -- and either the sexual organs evaginate (go outward for males) or invaginate (go inward for females).
With AIS, the male external genitalia does not form because the fetus lacks the specific receptor protein to interpret testosterone or DHT and continue the development of primary male sex characteristics . At birth, a patient with AIS looks entirely female (although they have undescended testes, no ovaries, a short vagina, no uterus or fallopian tubes). It is usually not suspected until puberty.
After the onset of puberty (which is usually later than average), a portion of the testosterone (which the body's genetic coding can't transcribe properly) is converted to estradiol and the secondary female characteristics begin to develop. Interestingly, most AIS patients are beautiful women -- with supermodel figures.
I hope I was able to break it down comprehensively for you!
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Does Lady Gaga have Androgen Insensitivity Syndrome (AIS) ?
Two girls in my biology class did a report and presentation on AIS and said a bunch of famous people with it. They said Lady Gaga had it but I think they are only assuming she does because of the rumors about her.
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i think it's all just rumours.... (
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does nicole kidman suffer from androgen insensitivity syndrome?
Women with Complete Androgen Insensitivity Syndrome are girls or women with internal testes, and normal female bodies except for shallow vaginas and lack of ovaries, uterus, menses or fertility.
That being said I wonder are you asking because of her relationship with Tom Cruise? Someone had to wear the pants in that relationship!
Perhaps you are basing it on her appearnce in Eye Wide Shut?
Perhaps the adoptions?
I have to admit before I researched it I thought it would mean being insensitve to androgenous men like her ex: Tom. (
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What's Androgen Insensitivity Syndrome?
Androgen insensitivity syndrome (AIS), also referred to as androgen resistance syndrome, is a set of disorders of sex development caused by mutations of the gene encoding the androgen receptor. The set of resulting disorders varies according to the structure and sensitivity of the abnormal receptor. Most forms of AIS involve a variable degree of undervirilization and/or infertility in XY persons of any gender. A person with complete androgen insensitivity syndrome (CAIS) has a female external appearance despite a 46XY karyotype and undescended testes. (
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what is androgen insensitivity syndrome?
Androgen insensitivity syndrome (AIS, or "Androgen resistance syndrome") is a set of disorders of sexual differentiation that results from mutations of the gene encoding the androgen receptor. It has also been called androgen resistance in the medical literature. The nature of the resulting problem varies according to the structure and sensitivity of the abnormal receptor. Most of the forms of AIS involve variable degrees of undervirilization and/or infertility in XY persons of either gender. A woman with complete androgen insensitivity syndrome (CAIS) has a female external appearance despite a 46XY karyotype and undescended testes, a condition termed testicular feminization in the past.
Major changes in the understanding and management of the various forms of AIS have occurred since 1990. Laboratory research has greatly expanded our understanding of the molecular mechanisms of the clinical features, including a rare neuromuscular disorder. More importantly, patient advocacy groups for AIS and other intersex conditions have increased public awareness of these disorders, helped revise the understanding of gender identity, emphasized the value of accurate and sophisticated information for patients, and induced physicians to re-evaluate the effectiveness of the surgical corrections attempted in past decades. Surgery is increasingly seen as an elective option even for the more ambiguous conditions. (
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Does anyone out there have Complete Androgen Insensitivity Syndrome???
If you have CAIS than could you please e-mail me or I'll e-mail you. I really need to see that there are people out there with the same condition that I am in. I was just recently diagnosed and I'm still having a hard time adjusting. Please reply if you have CAIS. I'm tired of feeling all alone in the world.
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Hi,
Sorry, I do not have androgen insensitivity syndrome ... although perhaps some would say I am insensitive, so I'll try not to act that way in my answer ;-)
But anyways, teens often feel isolated ... so feeling like you feel is pretty normal. In your case, you have a bigger reason than most to feel alone. It is difficult to be in your position, but I hope you can realize that you actually are not alone. In fact, although conditions like CAIS are rare, they are still common enough that there are plenty of others like you.
Also, as you are aware, without the action of androgens, a baby will grow into a girl. And she will often be fairly tall and slender ... so it is said that a fair number of models and actresses actually have CAIS. I can think of one very famous actress who is rumored to be androgen insensitive ... I won't name her, because I have only heard the rumors, but you could find her with google, I'm sure.
To find others with your condition who live close by, you could contact the group below - or other groups. You could also ask your doctors if they can put you in touch with a patient group for people with conditions similar to yours.
We are all unique and different from each other. For now, you feel like this aspect of your uniqueness is a difficult secret to bear. But don't worry, it is just the way you are, it isn't good or bad or too strange, it just is. If you give yourself some time and can find some people to talk to who will understand (I wouldn't tell your high school peers just yet!), I think you will be fine ... and maybe you'll even find the silver lining and do some modeling some day :-) (
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