1/2. Malignant melanoma of the vagina. A report of 15 cases.Twenty patients affected by vaginal malignant melanoma, 15 of which were evaluable for outcome, were observed from 1969 to 1993. Two patients died postoperatively, nine patients developed recurrences and four patients had no disease-free period. All patients died of their disease and the median overall survival was 19 months. The natural history of vaginal malignant melanoma differs from that of the skin with a more aggressive behaviour. Primary treatment should be wide local excision of the tumor.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
2/2. Metastasizing placental site trophoblastic tumor: immunohistochemical and dna analysis. 2 case reports and a review of the literature.Placental-site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia. The clinical behaviour of PSTT is usually benign, but sometimes it can be highly malignant with late recurrence and metastasis. We describe two cases of PSTT with pulmonary metastasis in patients aged 35 and 29 years respectively. The mitotic rate was elevated to 9 and 13 mitotic figures per 10 high-power fields respectively. Immunohistochemical staining showed a predominance of human placental lactogen (hPL) positive cells when compared with human chorionic gonadotropin (hCG) reactive cells in one case, and a reverse pattern in the other one. dna measurement in one case showed an aneuploid tumor with a tetraploid dna peak. The clinical behaviour of PSTT remains unpredictable, and there are no reliable means of predicting clinical outcome.- - - - - - - - - - ranking = 2keywords = behaviour (Clic here for more details about this article) |