1/12. female adnexal tumour of probable wolffian origin.We report a case of female adnexal tumour of probable wolffian origin, a rare tumour of the broad ligament, and discuss aspects of its origin, differential diagnosis and behaviour.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
2/12. Metastatic placental site trophoblastic tumor: a case report.Placental site trophoblastic tumor (PSTT) is very rare. It is an unusual variant of gestational trophoblastic neoplasia usually confined to the uterus, although 10% of patients have metastases. The clinical behaviour of PSTT varies and despite knowledge of its histology, diagnosis of this rare form of trophoblastic disease and prediction of its biological behaviour remains difficult due to only a few cases reported in literature.- - - - - - - - - - ranking = 2keywords = behaviour (Clic here for more details about this article) |
3/12. CD30-positive cutaneous T-cell lymphoma with concurrent solid tumour.Extranodal CD30 T-cell lymphomas seldom carry classical t(2;5) translocation and are usually anaplastic large cell lymphoma kinase protein negative. They cover a wide spectrum of histological and clinical behaviour. The prognosis of CD30 cutaneous T-cell lymphoma (CTCL) is good in the absence of nodal primary or disseminated disease. These lesions can undergo spontaneous regression, and overlap with the group of lesions of lymphomatoid papulosis. Although an increased incidence of solid tumours has been reported in patients with CD30 non-Hodgkin lymphoma of the skin, reports of concurrent malignancies are rare in CD30 CTCL. We report two patients with CD30 CTCL who, respectively, had concurrent disseminated gastric carcinoma and bilateral ovarian teratoma. Despite an aggressive clinical and histological appearance, both cases ran favourable clinical courses. The CTCL responded completely to chemotherapy in one patient, who eventually succumbed to gastric cancer. In the other patient, lesions regressed spontaneously after bilateral oophorectomy. A possible relationship between the lymphoma and the solid tumours is discussed.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
4/12. Late pulmonary metastasis in uterine PEComa.Perivascular epithelioid cell tumours (PEComas) other than angiomyolipoma, clear cell "sugar" tumour of the lung, and lymphangioleiomyomatosis are very rare mesenchymal tumours. The uterus seems to be the most prevalent site of involvement, but only 13 cases of uterine PEComa have been described. Three of these cases exhibited local aggressive behaviour and only one showed metastasis. Because of the extremely small number of cases, PEComas are considered tumours of uncertain malignant potential. This report describes a 68 year old woman, who presented with multiple pulmonary lesions seven years after the initial diagnosis of well differentiated endometrial stromal sarcoma. Histological and immunohistochemical analysis of the pulmonary lesions, in addition to re-evaluation of the primary uterine tumour, led to the final diagnosis of metastatic uterine PEComa. The findings indicate that any PEComa might have malignant potential. Spreading of this tumour to other organs might become evident even several years after primary manifestation.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
5/12. Disseminating myxoid leiomyosarcoma of the uterus.CASE REPORT: A 60-year-old female, para 1, menopausal for last 12 years was admitted with complaints of distention and pain abdomen for last 2 months. There was no history of postmenopausal bleeding. On abdominal examination there was a vague mass in lower abdomen reaching upto umbilicus. On vaginal examination, uterus was eight weeks size and a vague mass was felt around it through all fornices. On exploratory laparotomy uterus was studded with multiple friable hemorrhagic growths perforating from fundus and filling the peritoneal cavity. TREATMENT: Total abdominal hysterectomy with bilateral salpingo-oophorectomy with debulking of tumour and omentectomy was performed followed by postoperative adjuvant radiotherapy. CONCLUSION: Histopathology report confirmed it to be uterine myxoid leiomyosarcoma which is an extremely rare variant of uterine sarcoma with poor prognosis exhibiting malignant biologic behaviour.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
6/12. A 15-year-old girl with an expansively growing tumour.Often decisions have to be made in acute situations, when there is no time for discussion. The decision may have extreme consequences for the patient. The case is reported of a girl aged 15 years with an expansively growing tumour of the uterus. An intra-abdominal haemorrhage was caused by a ruptured vascular connection. The aggressive behaviour of the tumour aroused suspicion of malignancy. At emergency laparotomy the tumour was enucleated from the uterus. uterus and adnexa were preserved. The next problem in decision-making was the doubt concerning the pathological diagnosis: benign cellular leiomyoma or low-grade leiomyosarcoma. Now, 5 years after the laparotomy, there are no signs of recurrence. The problems concerning the diagnoses of 'leiomyoma' and 'leiomyosarcoma' are briefly reviewed.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
7/12. Mullerian clear cell carcinofibroma of the uterine corpus.A case of homologous Mullerian clear cell carcinofibroma occurring in the uterine corpus of a 71-year-old woman is described. The classification, histogenesis and possible biological behaviour of this unique tumour are briefly discussed.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
8/12. Carcinofibroma--a variant of the mixed Mullerian tumour. Case report.An endometrial neoplasm composed of both stromal and epithelial elements, in which only the epithelial element appeared malignant, is reported. Only two similar cases have previously been described. In view of the rarity of these neoplasms, little is known about their behaviour and this presents problems of management particularly in a young patient.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
9/12. Placental site trophoblastic tumour (trophoblastic pseudotumour): a study of four cases requiring hysterectomy including one fatal case.The clinico-pathological features of four patients with placental-site trophoblastic tumour (trophoblastic pseudotumour) are presented. One patient had the nephrotic syndrome associated with evidence of disseminated intravascular coagulation, with complete resolution after hysterectomy. In two patients the tumour extended beyond the uterus, and one of them died with many metastases in spite of intensive post-operative chemotherapy and 'second look' laparotomy. In three patients the tumour behaved as an actively infiltrative neoplasm resistant to chemotherapeutic regimes usually effective for choriocarcinoma. serum HCG levels were relatively low compared with those of choriocarcinoma. Histologically the tumours were predominantly composed of mononuclear cells supported by a variable amount of vascular stroma and lacked the bilaminar structure characteristic of choriocarcinoma. Scattered cells stained positively with anti-beta HCG and anti-alpha HCG antisera. Prior curettage was diagnostic in two of three cases. We did not find a clear correlation between mitotic activity and subsequent behaviour. Inflammatory cell infiltration and evidence of organisation around the tumour may be favourable prognostic indicators. We agree with a recent publication stressing the variable behaviour of this tumour, and emphasize the importance of serum HCG monitoring. Total surgical excision is usually feasible and in aggressive cases offers the best chance of eradication. We support the recent suggestion that 'trophoblastic pseudotumour' is an unsuitable name for a potentially lethal disease.- - - - - - - - - - ranking = 2keywords = behaviour (Clic here for more details about this article) |
10/12. Late cutaneous and muscular metastases of a uterine leiomyosarcoma after an initial simultaneous presentation with an adenocarcinoma.A case is reported of late cutaneous and muscular metastases of a uterine leiomyosarcoma following an initial simultaneous presentation with an endometrial adenocarcinoma. Such behaviour is discussed in view of the prognostic features of the original sarcoma.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
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