1/15. Treatment of resistant mycoplasma infection in immunocompromised patients with a new pleuromutilin antibiotic.patients with primary antibody deficiency (PAD) are prone to mycoplasma infection with unusual strains which may be resistant to conventional antibiotics. Mycoplasmas were isolated from the joint fluid (ureaplasma urealyticum) of two PAD patients with arthritis and from the cerebral spinal fluid (Mycoplasma maculosum) in one with meningitis, the latter probably originating from the patient's dog. Combinations of doxycycline and quinolones or macrolides failed to clear the infections, but after demonstrating in-vitro sensitivity to the pleuromutilin, Econor, for two of the isolates, all three patients responded to oral treatment with Econor. The infection was completely eradicated in two patients, with the emergence of a resistant strain in the third.Mycoplasma infection should be considered in PAD patients with unexplained sepsis. Pleuromutilins such as Econor are powerful new anti-mycoplasmal agents which provide an additional therapeutic option when patients fail to respond to conventional antibiotics.- - - - - - - - - - ranking = 1keywords = infection (Clic here for more details about this article) |
2/15. ureaplasma urealyticum as a possible cause of reflex sympathetic dystrophy syndrome.We describe the cases of two patients with clinical and radiological findings of the reflex sympathetic dystrophy syndrome (RSDS) in whom the history of a previous genito-urinary inflammation and high levels of ESR lead us to suspect a hidden reactive arthritis. However, instrumental examinations showed a characteristic picture of RSDS without evident signs of arthritis. In both patients we decided a treatment with quinolones because of detection of an ureaplasma urealyticum genito-urinary infection. This brought to complete remission of the joint symptoms in a few days. Our findings suggest that ureaplasma urealyticum can cause and sustain a RSDS picture, maybe with a reactive arthritis-like mechanism, and that an antibiogram-driven antimicrobial treatment can be rapidly effective against this disorder.- - - - - - - - - - ranking = 0.125keywords = infection (Clic here for more details about this article) |
3/15. mycoplasma hominis and Ureaplasma species brain abscess in a neonate.We report an infant with a mixed Mycoplasma and Ureaplasma brain abscess who was successfully treated with intravenous doxycycline and erythromycin. Therapeutic concentrations of doxycycline were demonstrated in cerebrospinal fluid. This report is evidence of the potential for Mycoplasma and Ureaplasma to produce focal central nervous system infection, as well as meningitis, in neonates and that use of doxycycline can be efficacious in the therapy of such infections.- - - - - - - - - - ranking = 0.25keywords = infection (Clic here for more details about this article) |
4/15. hydrops fetalis associated with ureaplasma urealyticum.A hydroptic newborn was born at 32 weeks' gestation and at the age of 14 h died of post-asphyxial syndrome. Immunologic causes of hydrops fetalis were excluded, as were anomalies and chromosomal aberrations. ureaplasma urealyticum was isolated in bronchial secretions, lung tissue and brain tissue of the newborn. Our findings suggest that U. urealyticum infection should be considered in the differential diagnosis of hydrops fetalis.- - - - - - - - - - ranking = 0.125keywords = infection (Clic here for more details about this article) |
5/15. Molecular diagnosis of ureaplasma urealyticum septic arthritis in a patient with hypogammaglobulinemia.OBJECTIVE. We report a hypogammaglobulinemic patient with a destructive oligoarticular arthritis, whose synovial fluid cultures were repeatedly sterile. methods AND RESULTS. We identified a ureaplasma urealyticum infection in his affected joints, using a polymerase chain reaction (PCR) assay. CONCLUSION. The PCR technique promises to be extremely valuable in the rapid and specific diagnosis of infectious arthritis.- - - - - - - - - - ranking = 0.125keywords = infection (Clic here for more details about this article) |
6/15. Recurrent infection stones with apparently negative cultures. The case for blind antibacterial treatment.infection stones in the urinary tract are always associated with infection with a urease-producing, urea-splitting organism. The most common of these organisms are easy to culture and identify and can be treated early either with an appropriate antibiotic or with an anti-urease agent. ureaplasma urealyticum and corynebacterium urealyticum are urease-producing organisms which are difficult to grow; their presence and effects frequently go undetected and untreated. Other organisms, as yet unknown, may also be involved in the same process. We report the first series of 8 patients with recurrent infection-type stones likely to have been caused by a "hard to grow" organism. Five patients never had a positive culture; in 2 patients 1 of 10 urine cultures grew a coagulase-negative staphylococcus and in 1 patient the same organism was grown from a stone but never in the urine. The clinical course of all of these patients was significantly improved after blind treatment with antibiotics and in one case with an anti-urease agent.- - - - - - - - - - ranking = 0.75keywords = infection (Clic here for more details about this article) |
7/15. Small and large bowel manifestation of leukocytoclastic vasculitis.Leukocytoclastic vasculitis is a disease mostly limited to the skin. Extracutaneous manifestations that include visceral involvement are normally self-limiting and not life-threatening. We describe a 44-year-old man with palpable purpura, polyarthritis and microhematuria who developed severe vasculitis of the small and large bowel. Initial laboratory tests confirmed leukocytosis, slightly elevated c-reactive protein and mildly increased erythrocyte sedimentation rate. skin biopsy revealed histological features typical of leukocytoclastic vasculitis. The search for trigger factors revealed urogenital infection with ureaplasma urealyticum. Severe abdominal pain followed cutaneous symptoms eight days after admission. Abdominal x-ray showed several air-fluid levels in the lower right abdomen and an abdominal CT scan revealed thickening of the intestinal wall in several segments of jejunum, ileum and colon. c-reactive protein rose from 32 mg/l to 107 mg/l. methylprednisolone pulse therapy rapidly improved gastrointestinal, cutaneous and articular symptoms. The aim of this report is to show the unpredictability of vasculitic disease and the difficulties in its classification. The report emphasizes the importance of adapting diagnosis and treatment according to disease severity rather than to the type of vasculitis. The specific etiological trigger remains unknown in this case, although a causal relationship with U. urealyticum infection is speculated.- - - - - - - - - - ranking = 0.25keywords = infection (Clic here for more details about this article) |
8/15. Disseminated ureaplasma urealyticum infection in a hypo-gammaglobulinaemic renal transplant patient.We report of a case of severe disseminated U. urealyticum infection in a 35-y-old kidney transplanted patient with CVID. Routine microbiological tests were negative. Six weeks after admission, abscess material was grown on Mycoplasma culture medium yielding U. urealyticum in high titres. The patient responded promptly to appropriate antibiotics.- - - - - - - - - - ranking = 0.625keywords = infection (Clic here for more details about this article) |
9/15. sternotomy infection due to mycoplasma hominis and ureaplasma urealyticum.mycoplasma hominis infections outside the urogenital tract are uncommon. An unusual case of sternal infection caused by both mycoplasma hominis and ureaplasma urealyticum is described. This is the first report found in the literature of mixed infection due to these microorganisms at this site. The outcome was favourable after drainage of the surgical wound and antibiotic therapy with clindamycin, gentamicin and doxycycline.- - - - - - - - - - ranking = 0.875keywords = infection (Clic here for more details about this article) |
10/15. ureaplasma urealyticum chorioamnionitis.Controversy reigns over the role of ureaplasma urealyticum in determining pregnancy outcome. U. urealyticum infection of the chorioamnion is strongly associated with chorioamnionitis (1-3), premature birth (2-4), and perinatal morbidity (4-6). We present 4 cases of U. urealyticum chorioamnionitis and associated morbidity and mortality.- - - - - - - - - - ranking = 0.125keywords = infection (Clic here for more details about this article) |
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