1/20. Oral carcinoma in a young man: a case of dyskeratosis congenita.We report a 28-year-old male with a voluminous growth of the tongue, present for 6 months. The histological examination revealed a squamous cell carcinoma. The patient was also affected by oral leukoplakia, nail dystrophy, reticulated poikiloderma of the neck and hyperkeratosis of palms and soles. On the basis of clinical features and histological findings, as well as findings from the family, the diagnosis of dyskeratosis congenita (DKC) was made.- - - - - - - - - - ranking = 1keywords = leukoplakia (Clic here for more details about this article) |
2/20. Proliferative verrucous leukoplakia: a case report.Proliferative verrucous leukoplakia (PVL) is a particularly aggressive form of oral leukoplakia that is resistant to treatment and presents a high risk of recurrence and malignant transformation. This article describes the microscopic and clinical characteristics of one case of PVL, which initially presented as hyperkeratosis with mild dysplasia and posteriorly developed multifocal areas and verrucous carcinoma despite treatment.- - - - - - - - - - ranking = 6keywords = leukoplakia (Clic here for more details about this article) |
3/20. "tongue sandwich" bolster for skin graft immobilization.BACKGROUND: Because of surface irregularities and continuous movement of the tongue, predictable immobilization of split-thickness skin grafts (STSGs) for tongue defects is difficult to achieve. methods: A novel composite, bilayer foam bolster was used to immobilize a STSG after reconstruction of more than 80% of the tongue mucosa after resection of a squamous cell carcinoma and extensive leukoplakia. Dorsal and ventral bolster components were placed over the STSG and affixed using transglossal, through-and-through sutures. RESULTS: The composite foam bolster provided uniform compression along the highly irregular and mobile skin-grafted surface. graft survival was excellent, and there were no complications. CONCLUSIONS: The "tongue sandwich" bolster is quickly and easily fabricated, immobilizes the tongue in a fully expanded position, and provides excellent apposition of STSGs to highly irregular and vascular surfaces.- - - - - - - - - - ranking = 1keywords = leukoplakia (Clic here for more details about this article) |
4/20. The use of the high power lasers in oral surgery.The treatment of 2989 patients with different type of lasers was described. The argon laser beam was used in 57 cases (portwine stains, telangiectasias, angiofibromas and other vascular lesions) and 84 operations were performed by Nd YAG laser (leukoplakia, hemangioma etc.) furthermore 53 operations by combined laser beams. 2795 operation by carbon dioxide laser were performed in precancerous states and other white lesions, benign tumors and tumor-like states, malignant tumors and other lesions. The laser procedures were performed under local anaesthesia. Operations were rapid and bloodless and excellent cosmetic and functional results were obtained. The experience gained with this group of patients suggests that the ideal case for laser treatment are leukoplakia, hemangiomas and other vascular tumors and lesions of the face and the oral cavity and clotting disturbance.- - - - - - - - - - ranking = 2keywords = leukoplakia (Clic here for more details about this article) |
5/20. dyskeratosis congenita vs. chronic graft versus host disease: report of a case and a review of the literature.dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome characterized by the triad of reticular pigmentation of the skin, nail dystrophy, and mucosal leukoplakia. DC is often associated with severe pancytopenia, and bone marrow failure is the principal cause of early mortality. Malignant transformation of mucosal leukoplakias may also occur. Rarely, aplastic anemia precedes the other clinical manifestations of the disease. We present a case of a 13-year-old boy who was diagnosed at age four with idopathic aplastic anemia, was treated successfully with an allogeneic bone marrow transplant, then subsequently developed skin, nail, and tongue lesions. While the initial impression was chronic graft-versus-host disease, additional work-up confirmed the diagnosis of DC.- - - - - - - - - - ranking = 2keywords = leukoplakia (Clic here for more details about this article) |
6/20. Recurrent oral condylomata acuminata and hairy leukoplakia: an early sign of myelodysplastic syndrome in an HIV-seronegative patient.Oral hairy leukoplakia (OHL) has been observed in all risk groups seropositive for HIV infection. Recently, this lesion has also been described in HIV-seronegative patients with immunosuppression of iatrogenic origin. We report on a hiv-1 and hiv-2 seronegative, heterosexual man affected by refractory anemia with ringed sideroblasts (myelodysplastic syndrome), who developed recurrent oral condylomata acuminata and OHL as an early clinical manifestation. The diagnosis of OHL was confirmed by identifying Epstein-Barr viral particles by electron microscopy and by in situ dna hybridization. HIV infection was ruled out using polymerase chain reaction and testing for hiv-1 and hiv-2 antibodies.- - - - - - - - - - ranking = 5keywords = leukoplakia (Clic here for more details about this article) |
7/20. dyskeratosis congenita: oral hyperkeratosis in association with lichenoid reaction.dyskeratosis congenita is an inherited disorder that usually presents in males, consisting of a triad of leukoplakia of the mucous membranes, nail dystrophy and skin pigmentation. Whilst most cases are X-linked, autosomal dominant and recessive forms have also been reported. The significance of the condition lies in premature mortality arising from either bone marrow failure or malignant change within the areas of mucosal leukoplakia. We present a case (X-linked recessive form) where the classic triad of signs were present, along with the development of lichenoid reaction in the buccal and labial mucosa. This is believed to be the first case in which such a reaction has been noted together with the oral hyperkeratosis. The identification of a white patch within the mouth of a child, in the absence of any other obvious cause must arouse suspicion of this rare condition. All clinicians should be aware of this rare genetic disorder so that early referral can be made and appropriate management instigated.- - - - - - - - - - ranking = 2keywords = leukoplakia (Clic here for more details about this article) |
8/20. Multifocal hairy leukoplakia associated with Kaposi's sarcoma.An HIV-seropositive patient presented with multifocal lesions of both hairy leukoplakia and Kaposi's sarcoma, hairy leukoplakia being present in the epithelium covering the Kaposi's sarcoma lesions. The findings suggest that hairy leukoplakia in immunocompromised patients is both more common and more widely distributed than is generally recognised.- - - - - - - - - - ranking = 7keywords = leukoplakia (Clic here for more details about this article) |
9/20. Oral hairy leukoplakia with extensive oral mucosal involvement. Report of two cases.Oral hairy leukoplakia (HL) is a lesion that occurs predominantly on the tongue in HIV-infected persons. Evidence strongly indicates that HL is related to the presence of Epstein-Barr virus in the epithelial cells. The lesion appears on the lateral border of the tongue as a painless, white plaque varying in size from a few millimeters to extensive lingual involvement. Histopathologically, the characteristic findings are hyperparakeratosis, hyperplasia, and ballooning of prickle cells resembling koilocytosis. HL is now considered a frequent, early, and specific sign of HIV infection and a strong indicator that AIDS will develop in the patient. We report on two cases of HL with marked oral mucosal involvement with extension to the pharyngeal mucosa.- - - - - - - - - - ranking = 5keywords = leukoplakia (Clic here for more details about this article) |
10/20. Oral hairy leukoplakia is not a specific sign of HIV-infection but related to immunosuppression in general.Oral hairy leukoplakia (HL) has been regarded as an early sign of HIV infection, and its clinical importance related to the poor outcome of the patients has been emphasized. Initially, HL was observed exclusively among male homosexuals, but subsequently demonstrated in all risk groups of HIV infection. The patient described in this article suggests that oral HL is not specific for HIV infection per se, but may be associated with immunosuppression also due to other causes. We describe an HIV-seronegative, heterosexual man suffering from an acute myeloblastic leukemia, who developed clinically and histologically typical HL while on cytostatics. biopsy showed areas with characteristic ballooning cells, and hyphae of yeasts were demonstrated with PAS-stain. Using the in situ hybridization technique, Epstein-Barr virus (EBV) dna with high copy numbers was disclosed in the superficial and intermediate cells, whereas human papillomavirus (HPV) dna (types 6, 11, 16, 18) was not present.- - - - - - - - - - ranking = 5keywords = leukoplakia (Clic here for more details about this article) |
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