1/15. sweat gland adenoma with predominant myoepithelial differentiated features: case report and immunohistochemical study.A 56-year-old man presented with a subcutaneous mass adjacent to the sternoclavicular joint region, which had predominant spindle-shaped myoepithelial cells and a small number of tubular or trabecular epithelial cells that resembled eccrine differentiation under a light microscope. Immunohistochemical studies showed positive staining for muscle-specific actin and vimentin in the myoepithelial cells, but staining was negative for S-100 protein and keratin. The tubular and trabecular epithelial cells stained positively for keratin, EMA and CEA. We believe that this rare tumor had the potential for biphasic differentiation and should be differentiated from other biphasic differentiated or mixed tumors in this site. Immunohistochemical staining was useful for diagnosis and differential diagnosis.- - - - - - - - - - ranking = 1keywords = spindle (Clic here for more details about this article) |
2/15. Primary sweat gland carcinosarcoma of the scrotal skin.BACKGROUND: carcinosarcoma is a biphasic tumor composed of malignant epithelial and mesenchymal elements. Although the tumors have been reported in different locations, they rarely occur in the skin and have not been reported in the skin of external genitalia. CASE REPORT: We present such a case in a 71-year-old Taiwanese man. He had had a long-term indolent nodule on scrotal skin, but it enlarged rapidly in 2 weeks. Wide excision of the tumor was performed. RESULTS AND DISCUSSION: The pathologic examination revealed a sweat gland carcinosarcoma consisting of admixed mucin-producing adenocarcinoma and solid spindle cell sarcoma. The two components exhibited contrasting immunohistochemical profiles with the epithelial component diffusely positive for epithelial markers and S-100 protein, while the sarcomatous component positive for vimentin and smooth muscle actin but negative for epithelial markers and S-100 protein. The immunoreactivity for S-100 protein in the epithelial component supports sweat gland origin. The tumor behaved aggressively. Local recurrence and distant metastases to lungs and brain occurred 6 months and 18 months later. The patient died of the disease 20 months after the initial diagnosis.- - - - - - - - - - ranking = 4.0855639153111keywords = spindle cell, spindle (Clic here for more details about this article) |
3/15. Lipomatous pleomorphic adenoma of the ceruminous gland.A case of lipomatous pleomorphic adenoma in the ceruminous gland is reported. A 69-year-old Japanese woman presented with a mass in the posterior wall of the cartilaginous external auditory canal. light microscopic examination revealed a well-circumscribed tumor composed of tubular structures with apocrine secretion and ceroid deposition, extensive mature adipocytes, and spindle-shaped myoepithelial cells in the myxoid and fibrous stroma. This case demonstrates the peculiar location of a lipomatous pleomorphic adenoma in the external auditory canal.- - - - - - - - - - ranking = 1keywords = spindle (Clic here for more details about this article) |
4/15. Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor?Eccrine angiomatous hamartoma (EAH) is a rare, benign condition characterized histologically by increased numbers of eccrine elements, as well as numerous capillary channels. In most cases, EAH arises as a single lesion; however, multiple variants have been reported. We report a 35-year-old female patient with multiple, sudoriparous, subcutaneous nodules on the right foot, which showed typical histopathological findings of EAH, and vascular components of the tumor consisted of thin-walled dilated vascular spaces intermixed with spindle cells and some histiocytoid endothelial cells representing spindle cell hemangioma (SCH). To our knowledge, the co-existence of EAH with SCH is a novel finding and not yet described.- - - - - - - - - - ranking = 24.513383491867keywords = spindle cell, spindle (Clic here for more details about this article) |
5/15. Eccrine angiomatous hamartoma of the finger leading to amputation.A case of eccrine angiomatous naevus in a 34-year-old pregnant woman is described. The tumour was located on the dorsal aspect of the distal phalanx of the left little finger causing severe pain. Partial resection provided no improvement and finally amputation was necessary. Histological examination revealed the typical appearance of an eccrine angiomatous hamartoma with a large number of eccrine ducts combined with vascular structures.- - - - - - - - - - ranking = 639.79019247859keywords = naevus (Clic here for more details about this article) |
6/15. A newly recognized feature of ectrodactyly, ectodermal dysplasia, clefting (EEC) syndrome: comedone naevus.A 21-year-old Black South African man with clinical features of ectrodactyly, ectodermal dysplasia, cleft lip/palate (EEC) syndrome is described. The patient had the following anomalies: hypoplastic, peg-shaped teeth; fine, silky hair; absent lacrimal puncta resulting in secondary photophobia, blepharitis and corneal opacities. The hands and feet showed absent digits, symphalangism and displacement of bone consistent with ectrodactyly. In addition, the patient had extensive comedone naevus, a feature not previously reported in EEC syndrome. We stress that the dysplastic ectodermal features of EEC syndrome are not typical of either hidrotic or anhidrotic ectodermal dysplasia but fall into a class of their own. Clefting of the lip and palate were absent due, it is postulated, to the variable expressivity of EEC syndrome.- - - - - - - - - - ranking = 3198.9509623929keywords = naevus (Clic here for more details about this article) |
7/15. Papillary eccrine adenoma.An example of papillary eccrine adenoma was seen. This benign cutaneous tumor has a diagnostic microscopic appearance that consists of multiple ducts lined by two or more layers of cells. The inner layer often forms one or multiple papillae of variable complexity. The stroma consists of patches of loosely arranged spindled cells and areas of hyalinized collagen. The latter often forms bands about the ducts. In addition to the foregoing, we observed focal squamous differentiation, clear cell change, connection of ducts to the epidermis, and prominent nerves within the stroma. Papillary eccrine adenoma also has several characteristic clinical features. The tumors are firm or hard nodules, frequently of many years' duration, and a large proportion are situated on the extremities of black persons.- - - - - - - - - - ranking = 1keywords = spindle (Clic here for more details about this article) |
8/15. sweat gland tumor with glandular and spindle cell features.We studied a sweat gland tumor by light and electron microscopy that displayed both well-differentiated glandular areas and an anaplastic spindle cell component suggestive of neuroendocrine differentiation. The Merkel cell or a primitive pleuropotential cell is considered to be the most likely cell of origin for this tumor.- - - - - - - - - - ranking = 20.427819576555keywords = spindle cell, spindle (Clic here for more details about this article) |
9/15. Naevus comedonicus in homozygous twins.This is the first case report of bilateral naevus comedonicus seen in a pair of twins in singapore. 3 other family members were similarly affected. Though both sexes were affected, there were more males affected as compared to females. Recent reports support a familial inheritance. Our pedigree showed an autosomal dominant inheritance. The extensive involvement seen in the twins suggest that they may be homozygous for this condition.- - - - - - - - - - ranking = 639.79019247859keywords = naevus (Clic here for more details about this article) |
10/15. Porokeratotic eccrine ostial and dermal duct naevus.With rare exceptions, the presence of cornoid lamellae in skin biopsy specimens is considered diagnostic of porokeratosis. Since the initial descriptions of this condition by Mibelli (1893) and Respighi (1893), there has been debate concerning its relationship to the eccrine sweat duct. This paper describes an epidermal naevus, which pathologically demonstrated gross examples of cornoid lamellae associated exclusively with the eccrine duct and ostia, and which appears to represent a naevus or benign hamartoma of these structures. This entity needs to be clearly differentiated from porokeratosis of Mibelli.- - - - - - - - - - ranking = 3838.7411548715keywords = naevus (Clic here for more details about this article) |
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