1/8. Meyerson phenomenon within a nevus flammeus. The different eczematous reactions within port-wine stains.Only few reports about eczematous reactions overlying nevi flammei exist. All of them were observed in children. The description of an eczematous reaction within a congenital nevus flammeus on the left lower leg of a male adult gives reason to discuss this rare phenomenon. eczema or inflammatory changes within a port-wine stain may mostly be a collision dermatosis with an atopic dermatitis, especially when they arise in children and are localized to the neck and face. When they are observed within a grossly visible vascular malformation, as for example in the Klippel-Trenaunay syndrome, they may have a pathogenesis similar to stasis dermatitis. In rare cases, an eczematous reaction within a nevus flammeus may be the result of genetic mosaicism and is interpreted as a variant of the so-called Meyerson phenomenon. ( info) |
2/8. Prolonged infection of the floor of the mouth in hyperimmunoglobulinemia E (Buckley's syndrome). Report of a case.A case of prolonged infection of the floor of the mouth with a generalized eczematous dermatitis in a 13-year-old boy is described. Immunologic examination revealed markedly elevated serum concentration of immunoglobulin e (IgE) and impaired neutrophil chemotaxis. The disorder was diagnosed as the hyperimmunoglobulinemia E (Buckley's syndrome) and was successfully treated with high doses of antibiotics and human immunoglobulin. ( info) |
3/8. HIV transmission by needle stick and eczematous lesion--three cases from germany.Two cases of documented hiv-1 transmission by needle stick and one case of probable transmission by eczematous lesion in three nurses in germany are reported in the period 1988 to 1991. In two of the cases the nurse knew of the AIDS status of the index patient. A review of the three cases reiterates the importance of repeated training on the prevention of accident and on measures to be taken after an accident, as well as the need to keep the workplace free of additional burden when AIDS or HIV-infected patients are treated. ( info) |
4/8. Generalized eczematous skin rash possibly due to HMG-CoA reductase inhibitors.We report on 3 patients who developed a generalized eczematous skin rash under treatment with simvastatin and pravastatin for hypercholesterolemia. These drugs are 3-hydroxy-3-methylglutaryl coenzyme a (HMG-CoA) reductase inhibitors and suppress cholesterol synthesis in the liver. Based on experimental data from the literature that showed eczematous changes in mice treated topically with the HMG-CoA reductase inhibitor lovastatin, we suspect that the rash observed in our patients may be a consequence of skin barrier dysfunction following inhibition of cholesterol biosynthesis. ( info) |
5/8. Late onset systemic lupus erythematosus diagnosed in an elderly man with unusual skin eruptions and sudden death.A rare case of late onset SLE in an elderly man presented with generalized toxicoderma-like eruptions. The rash first appeared at age 64 years and was characterized by dark or purplish erythematous eruptions disseminated over the body surface. Histological examination revealed marked liquefaction degeneration and leukocytoclastic vasculitis. Direct immunofluorescence study and serological examination results were suggestive of SLE; however, the patient had no episodes of photosensitivity, malar erythema, or arthralgia. He was diagnosed as having SLE 11 months after his first visit and died suddenly 16 months after onset. Elderly men with SLE can present with unusual clinical manifestations; careful examination of these patients is required to reach a correct diagnosis. ( info) |
6/8. Exposure to selected fragrance materials. A case study of fragrance-mix-positive eczema patients.The aim of the present study was to assess exposure to constituents of the fragrance mix from cosmetic products used by fragrance-mix-positive eczema patients. 23 products, which had either given a positive patch and/or use test in a total of 11 fragrance-mix-positive patients, were analyzed. In all cases, the use of these cosmetics completely or partly explained present or past episodes of eczema. Between 1 to 6 constituents of the fragrance mix were found in 22 out of 23 products. The cosmetics of all the patients sensitive to hydroxycitronellal, eugenol, cinnamic alcohol and alpha-amylcinnamic aldehyde were found to contain the respective substances. Exposure concentrations were seen to cover a large range. The content of hydroxycitronellal was, on average, 5 x higher in cosmetics from hydroxycitronellal-sensitive patients, compared to cosmetics from hydroxycitronellal-negative patients. It is concluded that exposure to constituents of the fragrance mix is common in fragrance-allergic patients with cosmetic eczema, and that the fragrance mix is a good reflection of actual exposure. ( info) |
7/8. Eczematous-like drug eruption induced by synergistins.The authors report 4 cases of eczematous-like drug eruption after oral ingestion of synergistins, pristinamycin (3 cases) and virginiamycin (1 case). The lesions occurred after contact sensitization with topical virginiamycin. The clinical symptoms appeared a few hours after ingestion: a generalized maculopapular eruption, sometimes with general symptoms of anaphylactic reaction. eczema appeared again on initial areas of contact dermatitis. There is a common allergenic group between these 2 antibiotics, which is a macrocyclic lactone. Physiopathology of this drug eruption is not clear: allergic reaction of the delayed type or anaphylactic reaction. patients allergic to virginiamycin should be strongly cautioned against oral pristinamycin. ( info) |
8/8. Extrapulmonary sarcoidosis: rapid spontaneous remission of marked splenomegaly.splenomegaly, when present as a manifestation of sarcoidosis, may cause pressure symptoms and hypersplenism. literature reports of giant splenomegaly are few in number and describe the use of aggressive intervention with systemic steroids and splenectomy. However, the natural history of splenic sarcoidosis is not well-defined, particularly the potential for spontaneous remission as seen in pulmonary sarcoidosis. In the case described here, a spontaneous remission of giant splenomegaly from sarcoidosis was observed. Careful follow-up appears to be appropriate management for at least some of these patients. ( info) |