1/8. Hemodynamic abnormalities in sodium monofluoroacetate intoxication.hypotension is one of the most important predictors of mortality in sodium monofluoroacetate (SMFA) intoxication. This paper reports the hemodynamic response in one fatal and another survival case of SMFA intoxication. Despite correction of hypovolemia and with inotropic support, the patients remained in shock. Hemodynamic observations have provided evidence that shock after SMFA intoxication is due to diminished systemic vascular resistance and increased cardiac output. This is the first report in which such an invasive hemodynamic investigation has been recorded in a clinical case of SMFA intoxication.- - - - - - - - - - ranking = 1keywords = intoxication (Clic here for more details about this article) |
2/8. Pyrimidifen intoxication.We present a case of lethal ingestion of pyrimidifen, a new insecticide with an unclear mode of action. The primary manifestations were coma and circulatory shock, leading to irreversible multiorgan failure. Pyrimidifen was detected in the patient's blood, urine, brain tissue, and gastric content samples. Minimal structural homology exists between pyrimidifen and organochlorines. Currently, no antidote is available, and therapy is primarily supportive.- - - - - - - - - - ranking = 0.5keywords = intoxication (Clic here for more details about this article) |
3/8. A sudden death during a saline drip in a schizophrenic patient with polydipsia.A young woman with polydipsia died suddenly while receiving a normal saline drip in a hospital for psychiatric care. Slight symptoms due to water intoxication, more specifically, nausea, vomiting, and anorexia, appeared and her serum sodium and potassium measured 106 and 1.7 mEq/l, respectively. General convulsions are thought to be the most common result of water intoxication in emergency cases, however, when she was found with circulatory collapse, no severe neurological symptoms were present. The cause of her collapse did not seem to be due to hyponatremia but to hypopotassemia. Although epinephrine is contraindicated with some psychiatric drugs, the doctor used it to raise blood pressure in treating circulatory collapse. It is possible that epinephrine induced cardiac arrest.- - - - - - - - - - ranking = 0.25keywords = intoxication (Clic here for more details about this article) |
4/8. iron poisoning.iron poisoning continues to be a major toxicologic problem, with major impact on the gastrointestinal and circulatory systems. Failure to recognize the severity of iron intoxication may result in an inappropriate level of intervention. By using estimates of the total body burden of iron, clinical symptoms, and the serum iron concentration, an appropriate decision can be made to initiate aggressive chelation therapy with deferoxamine. In severe intoxication, the use of intravenous deferoxamine is indicated, along with supportive care, with particular attention to maintaining the intravascular volume. Other important measures include correction of acidosis and disorders of coagulation and replacement of blood components when there is evidence of gastrointestinal hemorrhage. Under rare circumstances in which large numbers of iron tablets are present in the gastrointestinal tract, surgical removal may be indicated. In addition, measures such as hemodialysis and exchange transfusion should be reserved for those unusual poisonings in which more conservative therapy is unsuccessful. In rare cases of iron intoxication, late sequelae such as hepatic necrosis and gastrointestinal scarring with obstruction may occur. The prompt recognition and initiation of management of children with acute iron poisoning is the single most critical element in decreasing the morbidity and mortality associated with these products.- - - - - - - - - - ranking = 0.375keywords = intoxication (Clic here for more details about this article) |
5/8. The management of acute quinidine intoxication.A 16-year-old patient survived severe intoxication with quinidine. hypotension, rapidly progressing to oliguria and shock, was resistant to the usual therapeutic interventions but responded favorably to the use of an intra-aortic balloon pump. Some hemodynamic implications are discussed. pulmonary edema occurred and was treated with positive end-expiratory pressure. Electrocardiographic disturbances in conduction, transient bradycardia and recurrent ventricular arrhythmias characterized the initial 36-hour critical period. Unexplained electrolyte abnormalities occurred and further complicated management.- - - - - - - - - - ranking = 0.625keywords = intoxication (Clic here for more details about this article) |
6/8. Fatal cardiac arrhythmias and shock following yew leaves ingestion.A 40-year-old woman presented with vomiting and abdominal pain following voluntary ingestion of 150 yew leaves. She developed ventricular conduction defects and arrhythmias unresponsive to medical treatment after admission. She expired five hours after yew ingestion from irreversible cardiogenic shock. More attention should be given to this rare but severe intoxication for which no effective therapy is known.- - - - - - - - - - ranking = 0.125keywords = intoxication (Clic here for more details about this article) |
7/8. Drug intoxication: influence of hemoperfusion on human plasma fibronectin.Fibronectin is a glycoprotein belonging to the opsonic system and able to mediate phagocytosis by the reticuloendothelial system (RES). Severe intoxications are often followed by a diminished capacity of RES-clearance. patients with severe drug intoxications have lower concentrations of fibronectin in plasma than healthy persons. charcoal hemoperfusion lowers plasma fibronectin by an average of 4.7 mg/dl. Initial values below 15 mg/dl did not undergo a significant decrease in the case of hemoperfusion. Regarding these findings, determination of plasma fibronectin seems a useful parameter for monitoring RES function during treatment of drug-intoxicated patients by hemoperfusion.- - - - - - - - - - ranking = 0.75keywords = intoxication (Clic here for more details about this article) |
8/8. A fatal case of suicidal pentoxifylline intoxication.pentoxifylline is a xanthine derivative used in the treatment of peripheral vascular disease. It is considered to be a safe drug and to the best of our knowledge there are no reports in the medical literature of cases of fatal poisoning. There is only one previous report of a young woman who tried to commit suicide by taking a large amount of the drug but recovered. We report the case of a 54-year-old man who took a massive dose of pentoxifylline and died after 24 h from refractory shock. The blood levels of pentoxifylline were as high as 32.5 micrograms/ml where the average therapeutic level is 1.3 micrograms/ml.- - - - - - - - - - ranking = 0.5keywords = intoxication (Clic here for more details about this article) |