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1/43. Interactions between hiv infection and other sexually transmitted diseases.

    Mechanisms and implications of the interaction between hiv and other STDs such as syphilis, herpes simplex, Chlamydia and neisseria gonorrhoeae infection are presented and relevant case reports and trials described.
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2/43. Acute self-limiting hepatitis c after possible sexual exposure: sequence analysis of the E-2 region of the infected patient and sexual partner.

    We describe a case of symptomatic acute infection with HCV in a woman whose sexual partner had chronic hepatitis c. The patient cleared HCV rna 8 weeks after the onset of acute hepatitis and was found to be persistently HCV-rna negative during 90 weeks of follow-up. Part of the E-2 region of HCV was directly sequenced in the patient and her sexual partner. Four local controls with subtype-1a infection and 9 1a isolates obtained from GenBank were analyzed. The average nucleotide divergence between the sequences of the infected patient and her sexual partner was 5.1%, compared with an average nucleotide divergence of 19.4% (range 16.6-21.8%) between the sequences of the patient and those of controls. Comparison of the phylogenetic trees in the partial E-2 region showed that the sequence of the patient was closely related to that of her sexual partner. Our findings suggest that the infection was transmitted to the patient from her sexual partner. The resolution of acute hepatitis c in this case was probably related to the host rather than to intrinsic characteristics of the HCV genome.
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ranking = 0.6
keywords = infection
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3/43. Human-to-human transmission of pseudomonas pseudomallei.

    melioidosis, the clinical manifestation of infection with pseudomonas pseudomallei, has occurred infrequently in American citizens; almost all reported cases have been in vietnam veterans, usually associated with respiratory disease. A vietnam veteran from mississippi developed chronic prostatitis, with no other clinical manifestations, during service in vietnam, and P. pseudomallei was isolated from prostatic secretions 2 years after his return to the united states. The patient had had sexual contact with four women including his wife since his return from vietnam. Vaginal and cervical cultures and serum samples were obtained from the four women, and serum samples and cultures of semen were obtained from the patient. Vaginal swabs and semen cultures were negative for P. pseudomallei. The patient and his wife had hemagglutination titers (greater than 640) diagnostic of P. pseudominallei infection. This occurrence of venereal transmission is the first report of person-to-person spread of P. pseudomallei infection.
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ranking = 0.6
keywords = infection
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4/43. Infectious diseases. 6: Sexually transmitted infections: new diagnostic approaches and treatments.

    1. Commercially available nucleic acid amplification assays (eg, polymerase or ligase chain reaction) are now the "gold standard" tests for genital chlamydial infection and also have a role in screening for gonococcal infection. 2. Single-dose oral antibiotics are available for treatment of chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis infections. 3. Strains of N. gonorrhoeae in urban australia are often penicillin resistant, while strains from South East asia and those in homosexually active men may show high-level resistance to quinolones. 4. Imiquimod, a novel immune-response modifier, is now available for effective, safe, self-administered treatment of genital warts. 5. The Pap smear remains the cornerstone of screening for precursor lesions of cervical cancer, but human papillomavirus genotyping may have a role in clinical decision-making for women with equivocal or early precancerous lesions. 6. Treatment of primary genital herpes changes the clinical course, and long-term suppressive therapy is effective for those with multiple recurrences. New technologies have made diagnosis and screening easier for patients and clinicians
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ranking = 1.4
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5/43. Managing the very young patient: a conflict between the requirements of the Children Act and the VD regulations?

    We describe the case of a 12 year old girl who presented requesting screening for sexually transmitted infections and discuss a conflict between concerns of clinicians to maintain confidentiality and concerns of social workers to investigate the possibility of sexual abuse.
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keywords = infection
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6/43. internet sex-seeking leads to acute hiv infection: a report of two cases.

    The use of the internet provides a rapid medium for identifying potential sexual partners and arranging in-person meetings that often result in sex. There is growing concern that the internet facilitates the transmission of sexually transmitted diseases and hiv. We report the first two cases of acute hiv infection after internet chat room encounters. physicians should address the potential risks to sex seekers who use the internet. hiv prevention efforts that target internet sex seekers are needed.
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7/43. Multiple sexually acquired diseases occurring concurrently in an hiv positive man: case report, diagnosis and management.

    A case of an hiv positive man with multiple sexually acquired disease occurring concurrently is described. risk behaviours that could have predisposed him to hiv infection are discussed. The factors which might have interacted to make the sexually acquired infections severe and difficult to treat are postulated.
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8/43. Sexually transmitted disease, ethnomedicine and health policy in africa.

    Compared with both industrialized countries and other less developed parts of the world, most of sub-Saharan africa suffers inordinately from sexually transmitted diseases (STDs). It has high prevalence rates of traditional STDs, such as gonorrhea and syphilis, and if accurate seroprevalence surveys were to be done, it would probably prove to have the highest hiv seropositive incidence in the world. Unlike the pattern in the West, AIDS is primarily a heterosexually transmitted disease in africa. This appears to be largely because of the prevalence of other untreated or improperly treated STDs. Therefore to lower the incidence of STDs would be to curtail the spread of hiv infection. The problem becomes how exactly to accomplish this. Most STD cases are never even presented at biomedical health facilities; they are presented to traditional healers. Both healers and their patients seem to believe that traditional STD cures are more effective than 'modern' cures, although the former are probably biomedically ineffective. While there is scant ethnomedical literature on STDs in africa, the present paper presents swaziland findings and related evidence from other African societies that the ultimate cause of several common STDs is believed to be the violation of norms governing sexual behavior, requiring traditional rather than biomedical treatment. Traditional healers therefore need to be a central part of any scheme to lower the incidence of STDs.
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ranking = 0.2
keywords = infection
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9/43. Evaluating dysuria in adolescent females.

    adolescent females presenting with acute dysuria in primary care settings are often assumed to have urinary tract infections and are evaluated accordingly. dysuria, with or without a change in vaginal discharge, is also often associated with sexually transmitted infections, usually urethritis, even when the patient does not report a history of sexual activity. An adolescent female with dysuria, an abnormal urinalysis, and a negative urine culture has a high probability of having a sexually transmitted infection. Although providers who treat adolescents should not assume all of their patients are sexually active, it is essential that they ask questions about their patients' past and present sexual activity and consider the possibility of sexually transmitted diseases in young women presenting with this symptom.
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ranking = 0.6
keywords = infection
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10/43. lymphogranuloma venereum in human immunodeficiency virus-infected individuals in new york city.

    lymphogranuloma venereum (LGV), or chlamydial proctitis, is a classic sexually transmitted disease with prominent gastrointestinal manifestations. The disease has received little attention in recent years, especially in relation to human immunodeficiency virus (hiv) infection. However, outbreaks of LGV have been reported in several large cities in europe and the united states over the past few years, occurring in both hiv-infected and -uninfected individuals, and the reports have been largely limited to the sexually transmitted disease literature. We recently diagnosed four cases of chlamydial proctitis in hiv-infected individuals, who had different clinical presentations but very similar endoscopic and histopathologic features, as well as prompt and complete response to therapy. It is important for gastroenterologists to recognize that LGV may be reemerging as a relevant clinical entity, because of its similarity to inflammatory bowel diseases and its response to treatment with antibiotics.
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ranking = 0.2
keywords = infection
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