1/6. Malignant transformation in congenital sebaceous naevi in childhood.Sebaceous naevi are uncommon congenital skin lesions with a well-recognised potential for neoplastic change. They should be considered premalignant lesions as malignant degeneration, most commonly basal cell carcinoma and squamous cell carcinoma, occurs with a lifetime risk of between 5% and 22%. This incidence is equal to that of actinic keratosis and exceeds that of oral leukoplakia. Such change, however, is rare before puberty. Basal cell carcinoma may develop in children with naevoid basal cell carcinoma syndrome, xeroderma pigmentosum and rarely de novo but sebaceous naevus is the only solitary lesion in childhood associated with the development of basal cell carcinoma. We present two cases of malignant transformation in a congenital sebaceous naevus occurring in childhood and review the literature and discuss the evidence upon which to base management guidelines.- - - - - - - - - - ranking = 1keywords = naevus (Clic here for more details about this article) |
2/6. Squamous cell carcinoma complicating naevus sebaceous of Jadassohn in a child.We present a case of squamous cell carcinoma arising in a naevus sebaceous of Jadassohn (NSJ) in a 15-year-old girl. Both these events are rare, and this is the first reported case of a squamous cell carcinoma developing in NSJ in a child. The previous literature on sebaceous naevi and malignancies arising thereof is reviewed and discussed. Early excision is recommended in any cases of nodular change in sebaceous naevi in all age groups.- - - - - - - - - - ranking = 2.5keywords = naevus (Clic here for more details about this article) |
3/6. Linear sebaceous naevus syndrome and resistant rickets.The association between vitamin-D-resistant rickets and linear sebaceous naevus syndrome is extremely rare. Only eight cases have been described in the English literature and in none were the skeletal aspects addressed. We present three new cases and describe the musculoskeletal features. The details and outcome of surgery for correction of the deformities are discussed. The disturbances of metabolism of vitamin d and the effects of pharmacological treatment are also described.- - - - - - - - - - ranking = 2.5keywords = naevus (Clic here for more details about this article) |
4/6. Squamous cell carcinoma and basal cell carcinoma arising in a naevus sebaceous of Jadassohn: case report and literature review.The development of a basal cell carcinoma within a naevus sebaceous of Jadassohn (NSJ) has commonly been reported. However, the development of a squamous cell carcinoma (SCC) is rare. There have been several reports of SCC arising within a NSJ but many contain little or ambiguous clinical information. A thorough review of the current English language literature has identified only three other well documented cases of SCC arising in a NSJ. Of these only one was a case of simultaneous occurrence of squamous and basal cell carcinoma. We report the second case of both malignancies arising within the same NSJ.- - - - - - - - - - ranking = 2.5keywords = naevus (Clic here for more details about this article) |
5/6. Sebaceous naevus of Jadassohn and primary mediastinal lipomatosis.A rare association of sebaceous naevus of Jadassohn and primary mediastinal lipomatosis is presented. These are two benign conditions that can have serious complications.- - - - - - - - - - ranking = 2.5keywords = naevus (Clic here for more details about this article) |
6/6. Coexistent orbital and cerebellar venous anomalies in linear sebaceous naevus syndrome.BACKGROUND: Orbital venous anomalies can result in significant morbidity and have been reported in association with other venous anomalies, some with the potential for serious complication. methods/RESULTS: We present a case of an orbital venous anomaly coexistent with a large cerebellar venous angioma and a linear sebaceous naevus. Clinical features, associations, complications and management principles are presented. CONCLUSION: Upon clinical recognition of an orbital venous anomaly, brain imaging and appropriate clinical assessment should be considered in light of the possibility of coexistence of potentially life-threatening lesions.- - - - - - - - - - ranking = 2.5keywords = naevus (Clic here for more details about this article) |