1/135. Unusual onset of rheumatoid arthritis with diffuse pulmonary nodulosis: a diagnostic problem.We describe a case of a 50-year-old woman presenting articular manifestations of rheumatoid arthritis associated with severe interstitial lung involvement related to multiple pulmonary nodules. diagnosis of diffuse pulmonary rheumatoid nodulitis was made only after video assisted thoracoscopic lung biopsies.- - - - - - - - - - ranking = 1keywords = nodule (Clic here for more details about this article) |
2/135. Successful treatment of methotrexate induced nodulosis with D-penicillamine.Accelerated nodulosis is a recognized complication of methotrexate (MTX) therapy in rheumatoid arthritis (RA). We describe 3 patients with accelerated nodulosis treated with D-penicillamine (D-Pen) while continuing MTX. The combination of D-Pen with MTX therapy resulted in regression of subcutaneous nodules in all patients, disappearance of pulmonary nodules in one patient, and resolution of vasculitic lesions in 2 patients. Clinical response was observed within the first few weeks of therapy and usually required moderate doses (500 mg/day). Our observations suggest that addition of D-Pen to MTX therapy can be an alternative therapeutic option for accelerated nodulosis in patients with RA.- - - - - - - - - - ranking = 2keywords = nodule (Clic here for more details about this article) |
3/135. colchicine therapy for low-dose-methotrexate-induced accelerated nodulosis in a rheumatoid arthritis patient.Accelerated nodulosis developed on the fingers of a woman successfully treated with low dose methotrexate for rheumatoid arthritis. colchicine therapy resulted in regression of these nodules for twelve months. To our knowledge, this is the first report in the dermatological literature on this relatively new entity in which the skin is also involved.- - - - - - - - - - ranking = 1keywords = nodule (Clic here for more details about this article) |
4/135. Relapse of cutaneous leishmaniasis in a patient with an infected subcutaneous rheumatoid nodule.Cutaneous leishmaniasis is a protozoal infection generally considered to be limited to the skin. In israel, the disease is common in geographically defined areas and is caused predominantly by leishmania major. Sporotrichoid subcutaneous spread has been reported but is uncommon. We describe a patient with rheumatoid arthritis, treated with methotrexate and prednisone, in whom numerous rheumatoid nodules concomitant with cutaneous leishmaniasis were found, mimicking sporotrichoid spread of the disease. In a rheumatoid nodule that was examined by electron microscopy, Leishmania parasites were found at intracellular and extracellular locations. This observation supports the hypothesis that cutaneous leishmaniasis parasites persist after clinical cure of the disease and may re-emerge as a result of immunosuppression.- - - - - - - - - - ranking = 6keywords = nodule (Clic here for more details about this article) |
5/135. Accelerated nodulosis during methotrexate therapy for refractory rheumatoid arthritis. A case report.Accelerated nodulosis (AN) is a potential complication of methotrexate (MTX) therapy for rheumatoid arthritis (RA). We report on a 62-year old man affected by seropositive RA who developed AN after five months of MTX treatment. MTX-dose reduction was followed by rapid regression of the skin nodules. The Authors describe the typical features of AN and discuss on the pathogenetic mechanisms.- - - - - - - - - - ranking = 1keywords = nodule (Clic here for more details about this article) |
6/135. aortic valve rheumatoid nodules producing clinical aortic regurgitation and a review of the literature.The majority of cardiac involvement in rheumatoid arthritis (RA) is an incidental finding at postmortem, as less than 3% of patients with RA have clinical cardiac signs or symptoms. Most cardiac involvement in RA involves the pericardium and has been known since Charcot first described an RA patient with pericarditis in 1881. Cardiac involvement takes two different forms: non-specific inflammatory changes and specific granuloma formation. Specific rheumatoid nodules in the heart are an infrequent complication of RA. This is the first case report of a surgically excised heart valve with rheumatoid nodules. A 74-year-old RA patient with a high seropositive rheumatoid factor presented with severe aortic regurgitation and underwent a valve replacement. The native aortic valve showed significant stenosis with multiple, classic rheumatoid nodules.- - - - - - - - - - ranking = 7keywords = nodule (Clic here for more details about this article) |
7/135. Benign rheumatoid nodules of childhood.The nodules associated with rheumatoid arthritis and rheumatic fever appear with other signs of active rheumatic disease. rheumatoid nodule-like lesions irrelevant to rheumatoid disease occasionally occur in children who are well and have no complaints associated with rheumatoid diseases. Laboratory tests are normal. Children with benign rheumatoid nodule are not at increased risk for rheumatic disease. No therapy or prophylaxis is required. We present a two-year-old girl with a subcutaneous nodule on the right pretibial region who was diagnosed with clinical and histological findings.- - - - - - - - - - ranking = 8keywords = nodule (Clic here for more details about this article) |
8/135. Multiple neuromas coexisting with rheumatoid synovitis and a rheumatoid nodule.The authors present a rare case of multiple intermetatarsal neuromas coexisting with rheumatoid synovitis and a rheumatoid nodule. A brief review of rheumatoid nodules as a source of forefoot pain and a review of the relevant literature are provided. A rheumatoid nodule is just one of the many diagnoses that must be considered when one encounters pedal symptoms similar to those associated with Morton's neuroma.- - - - - - - - - - ranking = 7keywords = nodule (Clic here for more details about this article) |
9/135. Multiple epidermal inclusion cysts in a patient with rheumatoid arthritis: a case report.A construction worker with rheumatoid arthritis presented with multiple soft tissue masses on the volar surface of the palm and digits. A misdiagnosis of rheumatoid nodules was made secondary to the patient's history of rheumatoid arthritis. Subsequent excision confirmed multiple epidermal inclusion cysts, which was not entertained in the preoperative differential diagnosis. Follow-up evaluation 3 years later revealed no evidence of local recurrence. Based on our literature review, multiple epidermal inclusion cysts is a rare entity and has not been reported in a patient with rheumatoid arthritis.- - - - - - - - - - ranking = 1keywords = nodule (Clic here for more details about this article) |
10/135. rhabdomyolysis and aggravation of arthritis in a rheumatoid arthritis patient as a result of sepsis due to staphylococcus aureus infection of a rheumatoid nodule; a catastrophic outcome.A 63-year-old man with rheumatoid arthritis presented with rhabdomyolysis and intractable arthritis of acute onset. He was diagnosed to have sepsis due to staphylococcus aureus infection through of an ulcerated rheumatoid nodule. staphylococcus aureus isolated from pus in the ulcerated rheumatoid nodule and a blood sample obtained from the heart post-mortem produced the toxic shock syndrome toxin-1 (TSST-1). The TSST-1 and/or unmethylated CpG motifs in the oligonucleotides present in a bacterium, staphylococcus aureus in this case, might be implicated in the induction of rhabdomyolysis and intractable arthritis.- - - - - - - - - - ranking = 6keywords = nodule (Clic here for more details about this article) |
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