1/5. clofazimine. A new agent for the treatment of pyoderma gangrenosum.Eight patients had pyoderma gangrenosum. They were given a phendimetrazine tartrate derivative, clofazimine (Lamprene [Britain]), which is a chemotherapeutic agent used mainly in certain mycobacterial infections and which also has phagocytosis-enhancing properties. The effect of this drug was remarkably good, with rapid healing of the lesions commencing 3 to 14 days after treatment was started. The mechanism for the effect of clofazimine in pyoderma gangrenosum is not known.- - - - - - - - - - ranking = 1keywords = bacterial infection (Clic here for more details about this article) |
2/5. tinea capitis in adult women masquerading as bacterial pyoderma.tinea capitis is generally thought to be a common disease in children but not in adults. Adults with tinea capitis generally present with scale and alopecia. We report 3 adults with inflammatory tinea capitis caused by trichophyton tonsurans that resembled a bacterial infection. Of these patients, 2 were initially given a diagnosis of bacterial pyoderma. All patients were successfully treated with oral antifungal agents. One patient had significant eosinophilia that resolved with treatment. We conclude that tinea capitis should remain in the differential diagnosis of adults with alopecia and pyoderma-like presentations. A biopsy specimen was helpful in making the diagnosis in 2 of the 3 patients, but fungal culture confirmed the diagnosis in all cases.- - - - - - - - - - ranking = 1keywords = bacterial infection (Clic here for more details about this article) |
3/5. Localized blastomycosis-like pyoderma with good response to cotrimoxazol and cryotherapy.blastomycosis-like pyoderma is an unusual, exaggerated, vegetative-tissue reaction to a prolonged primary or secondary bacterial infection. It is a rare disease, usually seen in immunocompromized patients. We report a case of localized blastomycosis-like pyoderma responding poorly to classic treatments, but that gave a dramatic response to a combination treatment of cotrimoxazol and cryotherapy.- - - - - - - - - - ranking = 1keywords = bacterial infection (Clic here for more details about this article) |
4/5. blastomycosis-like pyoderma--report of a case responsive to combination therapy utilizing minocycline and carbon dioxide laser debridement.blastomycosis-like pyoderma is an uncommon reaction pattern to a superficial bacterial infection in persons with a variety of predisposing conditions such as chronic ethanol use and poor nutrition. We are reporting a case that initially responded poorly to previously described treatment regimens but responded well to combination treatment with carbon dioxide laser debridement and long-term minocycline.- - - - - - - - - - ranking = 1keywords = bacterial infection (Clic here for more details about this article) |
5/5. blastomycosis-like pyoderma.Seven patients with blastomycosis-like pyoderma had skin lesions of four months' to six years' duration. The criteria for the diagnosis of blastomycosis-like pyoderma include the clinical presentation of large verrucous plaques with multiple pustules and elevated border, pseudoepitheliomatous hyperplasia with abscess histologically, and the growth of at least one pathogenic bacteria from the culture of a tissue-biopsy specimen. The differential diagnosis includes deep fungus infection (especially North American blastomycosis), bromoderma, pyoderma gangrenosum, mycobacterial infections, giant keratoacanthoma, and squamous cell carcinoma. Generally, the patients had one or more conditions that could have affected their systemic or local immunologic competence to infection. We believe that the clinical and histologic features in these cases of blastomycosis-like pyoderma were produced by an unusual, exaggerated, vegetating-tissue reaction to a primary or secondary bacterial infection.- - - - - - - - - - ranking = 2keywords = bacterial infection (Clic here for more details about this article) |