1/12. Congenital infection with human herpesvirus 6 variant B associated with neonatal seizures and poor neurological outcome.Human herpesvirus 6 (HHV 6) has neurotropic and neuroinvasive properties. The virus has been found in the cerebrospinal fluid of many children with aseptic meningoencephalitis. Intrauterine transmission has been documented by HHV 6 dna detection in cord blood specimens of apparently healthy newborns and in fetuses following spontaneous abortions. A patient is described with early neonatal afebrile seizures resulting from a congenital HHV 6 variant B infection disclosed by repeated detection of viral genome by polymerase chain reaction (PCR) in cerebrospinal fluid in the first days of life. At follow-up, magnetic resonance imaging (MRI) studies disclosed hyperintensities in the periventricular white matter and basal ganglia, associated with cerebral atrophy. Further follow-up at 18 months revealed poor neurological outcome with mild neurodevelopmental retardation, strabismus and hypertonia of legs. This report provides evidence of neurological involvement after HHV 6 vertical transmission, and the association with neurological sequelae.- - - - - - - - - - ranking = 1keywords = herpesvirus (Clic here for more details about this article) |
2/12. Roseola infantum in pregnancy. A case report.Roseola infantum (exanthem subitum) was first described as a specific syndrome by Zahorsky in 1913. It is a benign disease that occurs almost exclusively in infants and young children (six months to three years of age). We report a case of roseola in a pregnant woman. We were unable to find any prior reports of roseola in pregnancy. The classic presentation of roseola is characterized by high temperatures (103-105 degrees F) that last 3-5 days and resolve by crisis followed by the appearance of a morbilliform rash that lasts a few hours to a few days. The infectious agent is human herpesvirus-6. We recommend the addition of roseola to the differential diagnosis of rashes that occur in pregnancy. The potential danger to the fetus from this virus is unknown.- - - - - - - - - - ranking = 0.2keywords = herpesvirus (Clic here for more details about this article) |
3/12. Distribution of varicella-zoster virus dna and gene products in tissues of a first-trimester varicella-infected fetus.Precise information about varicella-zoster virus (VZV) infection in first-trimester fetuses remains sketchy. After varicella infection was diagnosed in a woman, her 12-week-old fetus was aborted and was investigated, by histological examination, virus culturing, polymerase chain reaction, in situ hybridization (ISH), and immunohistochemistry (IHC), for the presence of VZV infection. Only the results of the histological examination suggested the presence of alpha -herpesvirus infection, in the gastrointestinal tract and liver; results of ISH were positive for VZV, and results of IHC staining were positive for intermediate early protein 63 (IE63) but negative for glycoprotein E (gE), in the dorsal root ganglia (DRG), meninges, gastrointestinal tract, pancreas, smooth muscle, liver, and placental trophoblast, indicating the presence of a nonproductive, latency-like VZV infection. Only the gastrointestinal tract and liver exhibited simultaneous staining for IE63 and gE, a result suggesting that active replication of VZV was present. In conclusion, widespread nonproductive VZV infection in the absence of histological clues is an early event in VZV infection in fetuses. The observed gene-expression pattern in most tissues resembles that of latent VZV infection in DRG. Latency-like infection in nonneural cell types may potentially reactivate, leading to multifocal necrosis, fibrosis, and dystrophic calcifications, as observed in advanced congenital varicella syndrome.- - - - - - - - - - ranking = 0.2keywords = herpesvirus (Clic here for more details about this article) |
4/12. Human herpesvirus 8 and Epstein-Barr virus coinfection in localized Castleman disease during pregnancy.Castleman's disease is a rare disorder characterized by two distinct entities with similar histology but different time course and therapeutic response. Multicentric plasma cell variant is highly associated with infection by human herpesvirus 8 (HHV-8), but the pathogenesis of the hyaline vascular variant is currently unknown. We report a pregnant patient who develops a localized axillary hyaline-type Castleman's disease in which HHV-8 dna sequences were detected in the lymph node lesions by nested PCR. In addition, the PCR multiplex also showed positivity for EBV. Immunohistochemical studies confirmed the presence of both viruses. Our results provide the first evidence of the presence of HHV-8 and EBV sequences in localized Castleman's disease, suggesting a possible role of the association of these herpes virus in the pathogenesis of this type of disorder. This case highlights that searching for HHV-8 and EBV sequences in cases of localized Castleman's disease is strongly advised.- - - - - - - - - - ranking = 1keywords = herpesvirus (Clic here for more details about this article) |
5/12. Disseminated herpesvirus infection. association with primary genital herpes in pregnancy.A patient with primary herpes simplex virus (HSV) type 2 genital infection had dissemination in the 37th week of her first pregnancy. This was manifested by severe hepatitis, pancreatitis, and genital lesions. Temporary improvement followed the delivery of a healthy infant by cesarean section. Encephalitis became evident on the third postpartum day, and recovery was complicated by profound bradycardia, possibly due to viral myocarditis. vidarabine was administered for seven days, and the patient survived with only mild neurologic sequellae. To our knowledge, this the fourth reported case of disseminated herpesvirus infection in pregnancy and the first due to HSV type 2. pregnancy must be considered as a possible predisposing factor in dissemination of primary HSV infection.- - - - - - - - - - ranking = 1keywords = herpesvirus (Clic here for more details about this article) |
6/12. guillain-barre syndrome associated with cytomegalovirus infection.Three cases of guillain-barre syndrome associated with serological evidence of active cytomegalovirus (CMV) infection are described. There are a variety of problems in establishing a causal role for cytomegalovirus in the development of the guillain-barre syndrome, the most important of which relates to the unequivocal demonstration of a primary infection preceding the condition. It is postulated that an immune-mediated mechanism probably plays an important role in pathogenesis whether it is associated with cytomegalovirus or other human herpesviruses.- - - - - - - - - - ranking = 0.2keywords = herpesvirus (Clic here for more details about this article) |
7/12. Herpes encephalitis during pregnancy: failure of acyclovir and adenine arabinoside to prevent neonatal herpes.A gravid woman with herpes Type II encephalitis delivered an infant with herpes neonatorum despite therapy with acyclovir. acyclovir was not measurable in the baby's serum 10 h after birth. The viral isolate was sensitive to acyclovir in vitro, and the neonatal infection responded to treatment with the drug. Prenatal antiviral therapy may be ineffective in preventing intrauterine herpesvirus infection.- - - - - - - - - - ranking = 0.2keywords = herpesvirus (Clic here for more details about this article) |
8/12. Systemic Herpesvirus hominis in pregnancy.Primary genital herpesvirus infection occurring in late gestation may provide the portal of entry for systemic infection. This report describes the clinical events and pathologic findings of lethal disseminated herpetic infection after a primary genital lesion in late gestation and reviews the physiologic changes of pregnancy that may cause the failure of normal defenses against the systemic spread of the virus.- - - - - - - - - - ranking = 0.2keywords = herpesvirus (Clic here for more details about this article) |
9/12. Rapid diagnosis of herpesvirus hominis infection of cervix and vagina before delivery.The incidence of asymptomatic vaginal and cervical Herpes virus hominis shedding in a group of 51 pregnant women near term was investigated by the method of indirect immunofluorescence. All women were tested serologically by the method of microneutralisation in order to diagnose latent HVH type 1 or HVH type 2 infection. The shedding of HVH, in most cases, was the consequence of the activated HVH latent infection. It was revealed that 13.72% of asymptomatic HVH type 1 shedding was from vagina alone, and 7.27% of asymptomatic HVH type 1 shedding was from cervix alone. The same percentage (17%) of HVH type 2 shedding was revealed from both the vagina and the cervix. All women whose cervical and vaginal smears showed positive HVH type 1 or HVH type 2 immunofluorescence were latently infected. We have no direct data to refuse or confirm the suggestions that Caesarian section is recommended in women with genital herpes. The fact that both vaginal and cervical asymptomatic shedding of HVH occur during pregnancy indicates that these women undergo the virologic examination near term. The evaluation of duration of asymptomatic shedding is needed. Close clinical and virologic observation will markedly reduce both clinical and subclinical HVH infection of the newborn infant. In such circumstances rapid diagnosis of HVH infection becomes extremely important in the pregnant women.- - - - - - - - - - ranking = 0.8keywords = herpesvirus (Clic here for more details about this article) |
10/12. Fatal herpetic hepatitis in pregnancy.Disseminated herpetic infections are becoming more commonly reported during pregnancy. Such infections almost always occur in the third trimester and are usually associated with a primary infection, which serves as a portal of entry. Because of the high fetal and maternal mortality associated with this condition, early diagnosis and treatment are essential. Disseminated herpesvirus infection must be considered whenever a pregnant patient has herpetic mucocutaneous lesions, vague systemic symptoms, or evidence of massive hepatic dysfunction.- - - - - - - - - - ranking = 0.2keywords = herpesvirus (Clic here for more details about this article) |
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