1/3. Uneventful propofol anaesthesia in a patient with acute intermittent porphyria.A patient with acute intermittent porphyria was anaesthetized with propofol as part of general anaesthesia for cholecystectomy. Post-operatively, no clinical sequelae resulted and urinary porphyrins did not exceed pre-operative values.- - - - - - - - - - ranking = 1keywords = anaesthesia (Clic here for more details about this article) |
2/3. Medical termination of pregnancy in acute intermittent porphyria.Acute intermittent porphyria is a rare autosomal dominant disease characterized by acute attacks of neuropsychiatric and neurovisceral dysfunction. In pregnancy, exacerbation of attacks in the form of seizures and acute abdomen occur due to hormonal changes. We report the case of a young woman presenting at 8 weeks of gestation requesting pregnancy termination. The patient suffered several episodes of acute abdomen and seizures in a prior pregnancy before the diagnosis was clinched. This case is reported because of its rarity and the limited obstetric experience of this disorder. Proper management depends on avoidance of precipitating factors. Anaesthetic drug safety in porphyria is reviewed and the choice of regional anaesthesia discussed.- - - - - - - - - - ranking = 0.2keywords = anaesthesia (Clic here for more details about this article) |
3/3. Elevated porphyrins following propofol anaesthesia in acute intermittent porphyria.A patient with acute intermittent porphyria was anaesthetised with propofol for a minor orthopaedic procedure. Postoperative urinary porphyrins were markedly raised compared to pre-operative values, although the patient remained clinically well. Caution should continue to be exercised when propofol is used in patients with acute porphyrias.- - - - - - - - - - ranking = 0.8keywords = anaesthesia (Clic here for more details about this article) |