1/12. Mucoepidermoid carcinoma arising in the glans penis.Mixed carcinoma (squamous and glandular) of the penis is a rare neoplasm with an unknown origin and a poorly defined prognosis. The mucoepidermoid carcinoma described herein has not been previously reported to our knowledge. The present carcinoma arose from and extensively ulcerated the squamous epithelium of the glans penis, including that surrounding the urethral meatus. The neoplasm was composed of well-differentiated nonkeratinizing squamous cell carcinoma associated with large areas of carcinoma formed by cell nests that contained poorly differentiated squamous elements and large eosinophilic to pale granular cells. Mucin stains revealed approximately one quarter of the pale cells contained mucous substances. These findings are virtually identical to the mucoepidermoid type of carcinoma seen in the cervix. The 3 previously reported cases of adenosquamous carcinoma of the penis demonstrated a relatively indolent course, with only one being associated with a single inguinal lymph node metastasis. That patient was alive and well 9 years following diagnosis. Our example of mucoepidermoid carcinoma appears to demonstrate a more aggressive course than those reported previously.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/12. leiomyoma of the corona glans penis.A 42-year-old man presented with an 8-mm elliptical indolent solid mass on the superior surface of the corona glandis at our institution 3 months after its appearance. The lesion was excised by using a wedge resection performed by a cool blade knife. The subsequent pathologic evaluation defined the lesion as a leiomyoma. Immunohistochemical analysis using the streptavidin-biotin peroxidase technique and immunoreactivity for cytokeratin, S100 protein, and the proliferative marker MIB1 was performed, confirming the pathologic diagnosis. Early local excision of these tumors is indicated because of the trend toward their dimensions increasing quickly, with subsequent difficulties for cosmetic glandis reconstruction.- - - - - - - - - - ranking = 2keywords = gland (Clic here for more details about this article) |
3/12. Early-stage penile carcinoma metastasizing to brain: case report and literature review.Early-stage penile squamous cell carcinoma with subsequent distant metastases is rare. We report a case of a 35-year-old man with Stage pT1pN0 penile squamous cell carcinoma who underwent circumcision and bilateral inguinal lymphadenectomy. Further in the disease course, the patient developed metastases in the kidney, adrenal gland, retroperitoneal lymph nodes, lung, and brain. He underwent multiple resections, whole brain radiotherapy, and several chemotherapy regimens. All these metastases were histologically confirmed. Forty months after the first diagnosis, the patient died of thromboembolic complications. This case was unique because of the unusual pattern of dissemination, especially the spread to the brain.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
4/12. An unusual case of extramammary Paget's disease. Paget's disease of the glans penis probably originating from a prostatic duct carcinoma (transitional cell carcinoma of the prostate).A patient, having been treated by total cystectomy and Bricker's conduit operation for prostatic duct carcinoma with intraepithelial extension into the prostatic urethra and bladder, developed an annular, psoriasiform eruption around the external orifice of the urethra two and one-half years later. A biopsy of this lesion showed pagetoid changes of the epidermis. Microscopic examination of the surgical specimen, consisting of the glans penis and corpus spongiosum, demonstrated intraepithelial-tumor permeation into the glans penis, penile urethra, and periurethral glands (Littre). It seems reasonable to conclude that this is an unusual case of Paget's disease of the glans penis which probably originated from a prostatic duct carcinoma.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
5/12. Preputial ectopic sebaceous glands mimicking molluscum contagiosum.The authors describe a 12-year-old boy with a peculiar presentation of preputial papular lesions similar to molluscum contagiosum. Histopathologic investigation revealed the presence of a sebaceous gland opening directly onto the surface and hyperplasia of the epithelium.- - - - - - - - - - ranking = 5keywords = gland (Clic here for more details about this article) |
6/12. Metastasis of prostate gland adenocarcinoma to penile and scrotal cutaneous tissues.The metastatic sites of adenocarcinoma of the prostate are well documented. Bone metastasis is the most frequently encountered site. skin metastasis is rarely reported. Its presence, however, is associated with a poor prognosis. The possible cause of cutaneous spread is discussed in the case report. The possible role that external-beam radiotherapy may play in this setting is also analyzed.- - - - - - - - - - ranking = 4keywords = gland (Clic here for more details about this article) |
7/12. Bronchogenic carcinoma metastasizing to the heart and penis. A case report.Metastasis to the heart and penis from a primary bronchial carcinoma is rare in almost all histological groups of cancer. Bronchial carcinoma is known to give rise to widespread haematogenous metastases, but there are certain sites where these metastases are more likely to occur--bones, brain, liver and adrenal glands. A case is reported in which undifferentiated squamous carcinoma of the bronchus spread to two extremely uncommon sites, the heart and the penis.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
8/12. granular cell tumor of penis and scrotum.Two cases of granular cell tumor of the external male genitalia are reported: one on the scrotum and one on the shaft of the penis. No previous reports of granular cell tumor of the scrotum appear in the literature. Each tumor was treated by simple excision and there was no recurrence. Each tumor showed cytoplasmic S-100 positivity. Tumor was seen in close proximity to small nerve fibers, sweat glands, and erectile smooth muscle. These findings are considered encroachments rather than evidence of origin from any of these structures. An immunohistochemical signature for granular cell tumor has developed in recent years, but, from a practical viewpoint, only the S-100 stain should be used for confirmation of the diagnosis.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
9/12. Ultrastructural study of extramammary Paget's disease--histologically showing transition from bowenoid pattern to Paget's disease pattern.Histological, immunohistochemical, and ultrastructural studies were performed on two cases of histologically unusual extramammary Paget's disease. Histologically, the central area of the lesions showed a bowenoid pattern, and the peripheral area showed typical extramammary Paget's disease. The transition zone showed an intermediate pattern. All these areas were positive for CEA and EMA, and negative for S-100 protein. Ultrastructurally, in the intermediate pattern, the tumour cells had abundant cytoplasmic glycogen, and the widened intercellular spaces contained numerous glycogen particles, which were probably secreted by the tumour cells. It is well known that eccrine glands, but not apocrine glands, secrete glycogen particles. Therefore, the present findings suggest that some cases of extramammary Paget's disease are a proliferation of germinative cells with eccrine gland differentiation.- - - - - - - - - - ranking = 3keywords = gland (Clic here for more details about this article) |
10/12. Surface adenosquamous carcinoma of the penis. A report of three cases.Three patients, aged 37, 72, and 74 years, with adenosquamous carcinoma of the penis are described. The duration of disease was 6, 9, and 144 months, respectively. Grossly a firm, white-gray granular exophytic mass was noted (7.6 cm average diameter). Microscopically, a mixed carcinoma showing squamous and glandular elements was present; the squamous component predominated. In two cases the adenocarcinoma was located in the perimeatal area of the glans. The periurethral glands were not involved. The glandular foci were discrete and had minimal admixture with the squamous carcinoma. Mucin material was present in the lumina, apical border, and cytoplasm. Immunohistochemically, cells showed positivity for carcinoembryonic antigen in glandular areas. The squamous cell carcinomas were of the "warty" variant in two cases and of the usual squamous cell type in the other case. In one patient, metastatic adenosquamous carcinoma was noted in one inguinal node and showed mucin secretion. This patient is alive and well 102 months after diagnosis. Another patient is alive with no evidence of disease 12 months after surgery, and the third was lost to follow-up. Adenosquamous carcinomas of the penis are unusual neoplasms probably originating in penile surface epithelium and in embryologically misplaced mucus glands of the perimeatal region of glans mucosa.- - - - - - - - - - ranking = 5keywords = gland (Clic here for more details about this article) |
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