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1/5. penicillinase-producing neisseria gonorrhoeae infection in adolescent prostitutes in detention.

    In the first quarter of 1983, four (17%) of 24 cases of neisseria gonorrhoeae infection diagnosed in female adolescent detainees in King County, washington were caused by penicillinase-producing (PPNG) strains. Twelve (3%) of 397 reported cases of female gonorrhea in the rest of King County during this time were caused by PPNG strains (p less than 0.01). All the detainees with PPNG infection were prostitutes. Their case histories are presented here. Three had signs and symptoms suggestive of pelvic inflammatory disease. In areas with endemic PPNG, all isolates of N. gonorrhoeae from female adolescent detainees should be tested for pencillinase production, and all prostitutes with genitourinary symptoms suggestive of gonorrhea should be treated with an antimicrobial resistant to pencillinase.
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keywords = gonorrhoeae
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2/5. Perihepatitis (Fitz-Hugh--Curtis syndrome). A review and case presentation.

    Perihepatitis, or Fitz-Hugh--Curtis syndrome (FHC), is a complication of pelvic inflammatory disease (PID). Although though in the past neisseria gonorrhoeae was thought to be the only etiological agent, recent data indicate that chlamydia trachomatis can produce the syndrome. Because cervical cultures frequently fail to demonstrate the presence of C. trachomatis, the serologic microimmunofluorescence antibody test is essential to diagnosis; the antibody titer in FHC syndrome is markedly higher than in PID without FHC syndrome. The classic presenting symptom of perihepatitis is severe right upper quadrant abdominal pain. If unnecessary diagnostic and surgical procedures are to be avoided, the FHC syndrome in the sexually active young woman must be included in the differential diagnosis of abdominal pain irrespective of its location. To illustrate the diagnosis and management of the FHC syndrome caused by C. trachomatis, a case of a 16-year-old adolescent female is presented.
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keywords = gonorrhoeae
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3/5. Prepubertal infections with neisseria gonorrhoeae: clinical and epidemiologic significance.

    The family constellations and epidemiologic circumstances of three prepubertal girls with vulvovaginitis due to neisseria gonorrhoeae are reported. In each instance, an infected asymptomatic man, himself a contact to a woman with pelvic inflammatory disease, could be implicated as the potential source of infection. In one instance, asymptomatic infection in a child was uncovered through epidemiologic investigation. Prepubertal gonococcal vaginitis is important not only as a potential indicator of child abuse, but also as a possible link to important transmitters of gonococcal infection. The need for meticulous epidemiologic investigation of these cases is stressed.
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keywords = gonorrhoeae
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4/5. chlamydia trachomatis infection in Fitz-Hugh-Curtis syndrome.

    We studied 23 patients with pelvic inflammatory disease associated with symptoms of pleuritic up'per abdominal pain, characteristic of Fitz-Hugh-Curtis syndrome (FHC). A fourfold or greater change in antibody titer to chlamydia trachomatis was demonstrated by microimmunofluorescence in 14; an IgG antibody titer greater than or equal to 1:1,024 was seen in 13; and IgM antibody was demonstrated in 11. Twenty (87%) of the 23 FHC patients, including all of the 12 with paired sera obtained at least 6 weeks apart, had serologic evidence of acute C. trachomatis infection. neisseria gonorrhoeae was isolated from seven (30%) of the 23 FHC cases, and C. trachomatis was isolated from three of 10. Two groups of matched controls were studied; one group with PID but without FHC, and the other without PID. A larger proportion of patients with FHC had serologic evidence of acute C. trachomatis infection than either of the two control groups (p less than 0.05 for each comparison). Among those with antibody to C. trachomatis, the geometric mean antibody titer for the FHC group (1:724) was significantly higher than that for the PID group (1:138) or for the non-PID group (1:103). Thus, FHC is not solely attributable to infection with N. gonorrhoeae; most cases are associated with acute C. trachomatis infection.
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keywords = gonorrhoeae
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5/5. pelvic inflammatory disease: an ongoing epidemic.

    In the absence of a practical screening test, diagnosis is based on physical and laboratory findings, a strategy compromised by low sensitivity and specificity--and by asymptomatic cases. Antibiotic combinations must be directed against a wide range of pathogens, including neisseria gonorrhoeae and Chlamydia trachomatis.
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ranking = 0.16666666666667
keywords = gonorrhoeae
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