1/17. Effectiveness of radiation therapy in nephrotic syndrome associated with advanced lung cancer.Paraneoplastic nephrotic syndrome is rare, bur occurs mostly in lung cancer. The glomerular lesion usually exhibits membranous nephropathy. Although surgical therapy has been shown to be effective, the treatment of a paraneoplastic nephrotic syndrome has always been a challenge. Currently no standard therapy has been established, if the paraneoplastic nephrotic syndrome is associated with advanced cancer with unresectable lesions. We present 2 cases having paraneoplastic nephrotic syndrome associated with advanced squamous cell carcinoma of the lung. radiation therapy of the primary tumor effectively caused regression of the paraneoplastic nephrotic syndrome without affecting the renal function. Our results suggest that irradiation can be the first choice in the treatment of nephrotic syndrome, if the primary tumor is unresectable.- - - - - - - - - - ranking = 1keywords = nephrotic syndrome (Clic here for more details about this article) |
2/17. Bilateral diffuse uveal melanocytic proliferation and uterine cancer. A case report.PURPOSE: To report a case of bilateral diffuse uveal melanocytic proliferation (BDUMP), a rare paraneoplastic syndrome causing visual loss in patients with systemic carcinoma. RESULTS: A 70-year-old woman developed visual symptoms 13 months after surgery and local irradiation therapy for uterine cancer. Following bilateral external beam irradiation supplemented with subsequent drainage of subretinal fluid in the left eye, the visual acuity improved from 0.01 to 0.15 in this eye only. The visual acuity remained at this level until she died 4 1/4 years after the onset of eye symptoms. CONCLUSION: This is the fourth case that survived longer than 24 months after the onset of visual symptoms of the 22 previously reported cases with BDUMP. It demonstrates that radiotherapy may have a vision-preserving effect in this group of patients. The patient also developed two different paraneoplastic phenomena--a nephrotic syndrome before and BDUMP after treatment for uterine cancer.- - - - - - - - - - ranking = 0.1keywords = nephrotic syndrome (Clic here for more details about this article) |
3/17. Two paraneoplastic syndromes in a patient with ovarian cancer: nephrotic syndrome and paraneoplastic cerebellar degeneration.BACKGROUND: A paraneoplastic syndrome-a rare, indirect system disturbance located distant from a neoplasm-has been reported in association with ovarian cancer. CASE: Two paraneoplastic syndromes-nephrotic syndrome and paraneoplastic cerebellar degeneration (PCD)-developed in a patient who had no symptoms from ovarian cancer. She presented with the nephrotic syndrome. Evaluation for metastasis, including computed tomography (CT) scan and ultrasonography, showed a slightly enlarged right ovary and a 2-cm lower paraaortic lymph node on the right side. A 5-cm ovarian mass and multiple paraaortic lymph nodes were excised, and six cycles of carboplatin and paclitaxel were given. nephrotic syndrome symptoms had greatly subsided at 6 weeks after surgery. At 7 months after surgery, symptoms of PCD developed yet CT, CA-125 levels, and physical examination showed no evidence of ovarian cancer. CONCLUSION: To our knowledge, development of two paraneoplastic syndromes in one patient with ovarian cancer has not been reported. nephrotic syndrome resolved with treatment of the neoplasm whereas PCD did not.- - - - - - - - - - ranking = 0.6keywords = nephrotic syndrome (Clic here for more details about this article) |
4/17. nephrotic syndrome in chronic lymphocytic leukemia: a paraneoplastic syndrome?The association of malignancy and various glomerulopathies is a well recognized phenomenon. We report a case of nephrotic syndrome secondary to minimal-change disease in a patient with chronic lymphocytic leukemia (CLL) and review the literature on nephrotic syndrome in this disorder. Since the relative distribution of etiologies differ from what might be expected for primary nephrotic syndrome in a similar aged population, we propose that nephrotic syndrome is a potential paraneoplastic phenomenon associated with CLL. We hypothesize a possible etiologic role of different cell surface markers of the lymphocyte to explain the diverse renal histologic manifestations.- - - - - - - - - - ranking = 0.4keywords = nephrotic syndrome (Clic here for more details about this article) |
5/17. A case of paraneoplastic nephrotic syndrome in a patient with ovarian carcinoma.nephrotic syndrome is a rare manifestation of malignancy associated with paraneoplastic syndrome. Paraneoplastic nephrotic syndrome has been reported in various malignancies: malignant lymphoma, colon cancer, lung cancer and prostate cancer. However, an ovarian carcinoma associated with nephrotic syndrome has rarely been reported. Only six cases of ovarian carcinoma associated paraneoplastic nephrotic syndrome has been reported worldwide, but no cases have been reported in korea. Here, we report a case of paraneoplastic nephrotic syndrome in a patient with an ovarian carcinoma. The patient presented with ascites, proteinuria and hypoalbuminemia. An initial computed tomography (CT) scan and ultrasonography evaluations showed no specific findings suggestive of an ovarian tumor. Despite treatment for nephrotic syndrome, the symptoms became more aggravated. There after, follow up evaluation at Yonsei University Medical Center, including serum CA 125, pelvis MRI and peritoneal fluid examination were performed. On the pelvis MRI, a left ovarian mass was detected with an ascitic fluid collection. The serum CA 125 level was elevated to 2211 U/ml. The peritoneal fluid cytological examination showed malignant cells suggestive of an ovarian carcinoma. Combination chemotherapies including paclitaxel plus carboplatin, topotecan plus gemcitabine and oxaliplatin plus capecitabine were administered to the patient, and complete remission was achieved on image and tumor marker studies. There was complete recovery from the nephrotic syndrome with no evidence of ascites and proteinuria. These findings suggest that nephrotic syndrome caused by paraneoplastic syndrome can be resolved only after the complete control of the underlying malignancy.- - - - - - - - - - ranking = 1.1keywords = nephrotic syndrome (Clic here for more details about this article) |
6/17. Paraneoplastic nephrotic syndrome in advanced breast cancer patient. A case report.A case of paraneoplastic nephrotic syndrome (NS) is described five years after the diagnosis of breast cancer. A review of the literature shows that NS is a rare complication of breast carcinoma.- - - - - - - - - - ranking = 0.5keywords = nephrotic syndrome (Clic here for more details about this article) |
7/17. Glomerulosclerosis: a paraneoplastic phenomenon?Glomerulosclerosis is not classically considered a paraneoplastic glomerular lesion. Focal and segmental glomerulosclerosis (FSGS) has rarely been reported in association with solid tumours. We report three cases of FSGS and an additional case of collapsing glomerulosclerosis in patients presenting with nephrotic syndrome and malignancy.- - - - - - - - - - ranking = 0.1keywords = nephrotic syndrome (Clic here for more details about this article) |
8/17. Rectal cancer with paraneoplastic nephropathy: association of vascular endothelial growth factor.A patient with advanced rectal cancer was complicated by progressing proteinuria and hypoproteinemia. Low anterior resection was a procedure of choice. A surgical specimen obtained by intraoperative renal biopsy showed the findings of minimal change nephrotic syndrome. After surgery, nephropathy remitted promptly and completely. Her pre/postoperative serum level of vascular endothelial growth factor was 1,880/52.3 pg/ml, suggesting its elevation was associated with the nephropathy. immunohistochemistry revealed strongly expressed tumor vascular endothelial cell growth factor. Minimal change nephrotic syndrome is a rare type of paraneoplastic nephropathy, and successful remission may require therapeutic resection of the underlying tumor, or administration of a vascular endothelial growth factor antagonist if the tumor is unresectable.- - - - - - - - - - ranking = 0.2keywords = nephrotic syndrome (Clic here for more details about this article) |
9/17. nephrotic syndrome associated with pleural mesothelioma. An unusual paraneoplastic event.A case of association between nephrotic syndrome (membranous glomerulopathy) and pleural mesothelioma is presented. It is suggested that this association is a true paraneoplastic syndrome.- - - - - - - - - - ranking = 0.1keywords = nephrotic syndrome (Clic here for more details about this article) |
10/17. Chemotherapy influencing the course of nephrotic syndrome in colonic carcinoma.A 50-year-old man presented with the nephrotic syndrome (NS). Subsequent investigations showed this to be due to a membranous glomerulonephritis. He was found to have a primary colonic carcinoma with extensive intra-abdominal spread. He was treated with 5-fluorouracil (5FU) with excellent resolution of the NS for a period of 6 months. The disease eventually progressed and the NS recurred on cessation of chemotherapy. This is the first report of such a response to 5FU of which we are aware and emphasizes the usefulness of palliative chemotherapy even in 'resistant' solid tumors when they are complicated by the NS.- - - - - - - - - - ranking = 0.4keywords = nephrotic syndrome (Clic here for more details about this article) |
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