1/96. Radionuclide bone imaging in the surgical treatment planning of odontogenic keratocysts.Locally aggressive benign lesions of the jaws, such as odontogenic keratocysts and ameloblastomas, require complete excision in view of the high incidence of recurrence after incomplete surgical removal. Because of the limitations of conventional radiology as the sole technique for determining the extent of these lesions, the use of 99m-technetium-labeled bone-imaging agents is suggested. This method of defining the location of surgical margins is based on the agent's sensitivity as an indicator of subtle changes in bone metabolism. A case of an unusually large recurrent odontogenic keratocyst is presented in which the planning of the surgical procedure was predicated on the results of a bone scan of the jaws in addition to conventional radiology. This diagnostic procedure, especially when used in conjunction with conventional radiology, appears to be of considerable value in defining the extent of a variety of oral-maxillofacial bony lesions.- - - - - - - - - - ranking = 1keywords = jaw (Clic here for more details about this article) |
2/96. Glandular odontogenic cyst: a case report.Glandular odontogenic cyst (GOC) is an extremely rare lesion occurring in the jawbones. Sialo-odontogenic cyst was first described as a multicystic lesion resembling a botryoid odontogenic cyst (BOC) or a central mucoepidermoid carcinoma by Padayachee in 1987. In 1988, Gardner used the term "glandular odontogenic cyst" and considered it as a histologic variant of BOC. Most authors agreed that GOC was odontogenic because of the concurrent ball-like epithelial structure, ameloblastoma, squamous odontogenic tumor-like proliferation in its wall, or hyaline bodies in the epithelium lining. Recently, immunohistochemical studies of the cytokeratin profiles have also supported this concept. Its aggressive behavior and the recurrent tendency make it important. A new case of GOC in a 59-year-old male presented as a multilocular radiolucency in the anterior region of the mandible, invading the marrow space by epithelial islands is described with other clinicopathologic features and the literature is briefly discussed.- - - - - - - - - - ranking = 3.2304962381491keywords = mandible, jaw (Clic here for more details about this article) |
3/96. Computerized tomography in the management and follow-up of extensive periapical lesion.Radiographs are good diagnostic aids in endodontics, although they have limitations. The purpose of this article is to discuss the use of computerized tomography in differential diagnosis, treatment planning, follow-up and overall clinical management of complex periapical lesions. A clinical case of an extensive symptomatic periapical lesion of the upper jaw is presented, in which the use of computerized tomography allowed evaluation of the true extent of the lesion and its spatial relationship to important anatomical landmarks. Computerized tomography also provided specific information about the type of lesion and the degree of bone repair which had taken place 18 months after non-surgical treatment had been completed.- - - - - - - - - - ranking = 0.5keywords = jaw (Clic here for more details about this article) |
4/96. PTCH gene mutations in odontogenic keratocysts.An odontogenic keratocyst (OKC) is a benign cystic lesion of the jaws that occurs sporadically or in association with nevoid basal cell carcinoma syndrome (NBCCS). Recently, the gene for NBCCS was cloned and shown to be the human homologue of the drosophila segment polarity gene Patched (PTCH), a tumor suppressor gene. The PTCH gene encodes a transmembrane protein that acts in opposition to the Hedgehog signaling protein, controlling cell fates, patterning, and growth in numerous tissues, including tooth. We investigated three cases of sporadic odontogenic keratocysts and three other cases associated with NBCCS, looking for mutations of the PTCH gene. Non-radioactive single-strand conformational polymorphism and direct sequencing of PCR products revealed a deletion of 5 base pairs (bp) in exon 3 (518delAAGCG) in one sporadic cyst as well as mutations in two cysts associated with NBCCS, a nonsense (C2760A) and a missense (G3499A) alteration. This report is the first to describe a somatic mutation of PTCH in sporadic odontogenic keratocysts as well as two novel mutations in cysts associated with NBCCS, indicating a similar pathogenesis in a subset of sporadic keratocysts.- - - - - - - - - - ranking = 0.5keywords = jaw (Clic here for more details about this article) |
5/96. Glandular odontogenic cyst: absence of PTCH gene mutation.Glandular odontogenic cyst (GOC) is a rare jawbone cyst of odontogenic origin. Human patched (PTCH) is a tumour suppressor gene that has been recently associated with signalling pathways during odontogenesis. Recently alterations of this gene were found on sporadic odontogenic keratocysts. This evidence, together with the biological behaviour similarities of both lesions, and the absence of reports on molecular analysis of GOC, led us to hypothesize that PTCH gene mutations may underlie the tumorigenesis of GOC. Therefore the aim of this study was to report one additional case of GOC and investigate the PTCH gene of the cyst. No mutations were found in the splicing and coding regions of the PTCH gene. In conclusion, the PTCH gene does not seem to be involved in GOC pathogenesis.- - - - - - - - - - ranking = 0.5keywords = jaw (Clic here for more details about this article) |
6/96. Glandular odontogenic cyst. A rare entity with aggressive biological behaviour. A case report.Glandular Odontogenic cyst is an apparently rare jaw cyst characterised by typical histopathological features, propensity to reach large size and high rate of local recurrence, if not adequately treated. Identification of this cyst as a separate entity is important because of the difference in biological behaviour. We report a case of Glandular Odontogenic cyst occurring in maxilla.- - - - - - - - - - ranking = 0.5keywords = jaw (Clic here for more details about this article) |
7/96. Eosinophilic pustular folliculitis in association with nevoid basal cell carcinoma syndrome.This study reports on the clinical and light microscopic features of a nevoid basal cell carcinoma syndrome with the complication of eosinophilic pustular folliculitis. To the authors' knowledge, this is the first report of such an association, which is possibly due to immune dysregulation. Moreover, the patient experienced remission of eosinophilic pustular folliculitis after removal of the jaw cyst. One possible explanation for the remission is that a long-lasting TH, type inflammatory response as a result of the bone defect produces effective cytokines such as interferon-gamma.- - - - - - - - - - ranking = 0.5keywords = jaw (Clic here for more details about this article) |
8/96. Odontogenic keratocyst with mural cartilaginous metaplasia: a case report and a review of the literature.Odontogenic keratocyst displaying foci of cartilaginous metaplasia in the connective tissue wall has been previously reported but is considered rare. We report a case of a 66-year-old man with an odontogenic keratocyst of the mandible. Benign-appearing metaplastic cartilage was observed in the wall of this cyst, as well as in the recurrence. A benign clinical course is documented, and a review of the literature detailing 6 previously reported cases is presented.- - - - - - - - - - ranking = 2.7304962381491keywords = mandible (Clic here for more details about this article) |
9/96. Unusual CT appearance in an odontogenic keratocyst of the mandible: case report.An expansile lesion in the body of the left mandible had high attenuation (225 HU) on nonenhanced CT scans. Histologic examination revealed an odontogenic keratocyst with no evidence of mineralization or calcification within the lesion. The high attenuation was considered to be due to highly concentrated protein of thick, viscous keratin in the lumen of the keratocyst.- - - - - - - - - - ranking = 13.652481190746keywords = mandible (Clic here for more details about this article) |
10/96. A sequential approach to radiological interpretation.A case of large glandular odontogenic cyst of the mandible is presented in which the panoramic radiograph also demonstrated a soft tissue lesion consistent with carotid aneurysm. CT confirmed the bucco-lingual extent of the mandibular lesion and the presence of a soft tissue lesion consistent with an aneurysm of the internal carotid artery. CT angiography, MR angiography and US were used to rule out a carotid artery aneurysm prior to surgery of the mandibular lesion.- - - - - - - - - - ranking = 2.7304962381491keywords = mandible (Clic here for more details about this article) |
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