1/9. Neurocutaneous melanosis: a case of primary intracranial melanoma with metastasis.Neurocutaneous melanosis is a rare disorder characterized by the presence of large or multiple congenital melanocytic naevi and benign or malignant pigment cell tumours of the leptomeninges. Distant metastasis is unusual in primary leptomeningeal/intracranial melanomas. We present the case history of an adult male who had multiple primary intracranial melanomas associated with neurocutaneous melanosis (naevus of Ota) in the ophthalmic division of the left trigeminal nerve. Excision of the intracranial tumours was carried out in two stages, but the patient died 2 days after the second operation. autopsy showed multiple metastatic deposits in the liver. Symptoms and signs of raised intracranial pressure, the presence of Ota's naevus, and a dural-based mass or masses should alert the treating physician to suspect a primary leptomeningeal/intracranial melanoma.- - - - - - - - - - ranking = 1keywords = naevus (Clic here for more details about this article) |
2/9. Two cases of late onset Ota's naevus.Ota's naevus is among the dermal melanocytoses that show a distinct pattern involving skin innervated by the trigeminal nerve. Most cases present at birth or manifest clinically in early childhood. Cases of acquired lesions in adult onset have been reported rarely. We present two cases of late onset Ota's naevus which were confirmed by skin biopsies. Both patients underwent Q-switched alexandrite laser treatment with a dose of 8.0 J/cm2 given four or five times at 6 weekly intervals and showed some improvement.- - - - - - - - - - ranking = 3keywords = naevus (Clic here for more details about this article) |
3/9. Bilateral Ota naevus.We present the case of a 22-year-old woman, who had presented since the age of 15 a pale-blue spot spread on the right-hand side of her forehead and in her bulbar conjunctiva (first and second branches of the trigeminus nerve), consistent with Ota naevus. A few years later another with similar characteristics appeared on the other side of her forehead, cheek and sclera. No deafness, neurological defect nor visual loss were detected. We comment on the rarity of this case because the patient is Caucasian and also we explain the main complications derived of this disease and consider the therapeutic options.- - - - - - - - - - ranking = 2.5keywords = naevus (Clic here for more details about this article) |
4/9. Bilateral naevus of Ota: a rare manifestation in a Caucasian.The naevus of Ota (naevus fusculocoeruleus ophthalmomaxillaris) was first described by the Japanese dermatologist M. T. Ota in 1939. It has a reported incidence of 0.2% to 1% in the Japanese population. It usually occurs in the skin innervated by the first or second branch of the trigeminal nerve. The naevus comprises dermal melanocytes and is congenital or acquired during adolescence. Commonly associated lesions include scleral melanocytosis and other ocular manifestations as well as lesions of the tympanic membrane, oral and intranasal mucosa and leptomeninges. Diseases associated with Ota's naevus in rare cases are open-angle glaucomas and melanoma. The naevus of Ota in Europeans is a rare manifestation. We report the very rare case of a bilateral naevus of Ota associated with enoral melanocytosis in a white European person.- - - - - - - - - - ranking = 5keywords = naevus (Clic here for more details about this article) |
5/9. Hemi-naevus of Ota: perturbation of neural crest differentiation as a likely mechanism.We present a case of oculodermal melanosis that involves the lower eyelid and lower half of the globe in a very clearly defined fashion. We suggest that such a lesion is the result of a local change in embryonic environment occurring during a well-defined stage of ocular development, such that differentiation of neural crest cells into a melanocytic phenotype is favoured.- - - - - - - - - - ranking = 2keywords = naevus (Clic here for more details about this article) |
6/9. Malignant melanoma of the choroid in a naevus of Ota.A rare case of choroidal malignant melanoma in a naevus of Ota is described. This is the first reported case from asia outside the Japanese population. This case illustrates the need for close observation of all pigmented lesions of the eye.- - - - - - - - - - ranking = 2.5keywords = naevus (Clic here for more details about this article) |
7/9. Invasive naevus of Ota.A slowly invasive naevus of Ota was followed for 50 yrs. During this time multiple biopsies were considered to be benign cellular blue naevus. The left globe, orbit, frontal bone and meninges were excised to achieve clearance.- - - - - - - - - - ranking = 3keywords = naevus (Clic here for more details about this article) |
8/9. Dermal melanocytosis: a clinical spectrum.While most dermal melanocytoses are congenital or have an onset in early childhood, there is a group which is clearly acquired, with an onset in adult life. While the mongolian spot typically disappears in childhood, other dermal melanocytoses persist for life. A brief review of the clinical spectrum of the dermal melanocytoses is undertaken and three illustrative cases are described: a case of congenital naevus of Ota, a case of acquired bilateral naevus of Ota-like macules, and an unusual case of a congenital dermal melanocytotic lesion on the left had which began to spread in adulthood. The possibilities regarding the pathogenesis of this intriguing group of disorders are considered.- - - - - - - - - - ranking = 1keywords = naevus (Clic here for more details about this article) |
9/9. sturge-weber syndrome associated with naevus of Ota.The association of sturge-weber syndrome with naevus of Ota is an infrequently reported phenomenon and there are only four previously described cases in the literature. In this paper we briefly review the literature regarding the coexistence of vascular and pigmentary naevi and present an additional patient with the association of the sturge-weber syndrome and naevus of Ota.- - - - - - - - - - ranking = 3keywords = naevus (Clic here for more details about this article) |