11/16. Malignant melanoma within an intradermal nevus.We describe a case of malignant "dermal" melanoma that arose within a preexisting intradermal nevus. Clinically, the lesion had recently enlarged. Histologically, two patterns were noted. One was an intradermal nevus in the upper portion of the dermis; the other was a deeper nodule composed of malignant neoplastic cells that extended into the reticular dermis. No melanocytic epidermal junctional activity was noted. Despite careful clinical investigation, no alternative primary source was found. Neoplastic transformation of the intradermal nevus without junctional activity is our proposed interpretation of the lesion's histology. Immunohistochemical stains demonstrated that the deeper dermal neoplastic cells were positive for both HMB-45 and PCNA, whereas the superficial nevoid-appearing cells were negative; these findings support our postulate that this melanoma arose within an intradermal nevus. It is important to distinguish this neoplasm from other diagnostic possibilities, including a metastatic lesion originating from another site.- - - - - - - - - - ranking = 1keywords = cell (Clic here for more details about this article) |
12/16. Paramyxovirus-like inclusions in an intradermal nevus from a healthy woman.A healthy 52-year-old woman had an intradermal nevus removed from the right preauricular region. Histopathologic examination disclosed intranuclear and intracytoplasmic inclusions in many of the nevus cells. A basal-cell carcinoma, an additional intradermal nevus, and a fibrous papule of the nose were also excised, however, none of these lesions showed histologically similar inclusions within the lesions. Electron microscopic studies showed inclusions that were similar to those observed in cases of subacute sclerosing panencephalitis. Immunoperoxidase and polymerase chain reaction studies for the measles virus were performed, with negative results. The patient remains in good health 2 years after excision of the skin lesions.- - - - - - - - - - ranking = 0.66666666666667keywords = cell (Clic here for more details about this article) |
13/16. Mucinous naevocellular naevi.We report 4 cases of a naevocellular naevus variant containing abundant amounts of mucinous matrix. The mucinous matrix was alcian blue (pH 2.5) and Halle's colloidal iron positive and mucicarmine and PAS negative. When the blocks of tumours were cut down, regions typical of common intradermal naevi were found in all 4 cases. The differential diagnosis with mucinous carcinoma of the skin and myxoid malignant melanoma is discussed.- - - - - - - - - - ranking = 54175.464144482keywords = naevus, cell (Clic here for more details about this article) |
14/16. Recurrent compound naevus of gingiva.A case is described of a compound naevus of the gingiva. It was unusual in that it showed a number of recurrences and these appeared to be related to the hormonal status of the patient.- - - - - - - - - - ranking = 270868.98738907keywords = naevus (Clic here for more details about this article) |
15/16. Combined skin lesions.Four brief reports of combined skin lesions are presented: (1) combined basal cell epithelioma and histiocytosis X. (2) combined intraepidermal melanocytic neoplasia (melanoma in situ) and leukaemia cutis, (3) combined melanocytic naevus with pseudoepitheliomatous hyperplasia and desmoplastic trichoepithelioma, and (4) combined melanocytic naevus with lichenoid gold reaction. The importance of the occurrence of such lesions is discussed, as are the clinical and pathological diagnostic difficulties they sometimes pose.- - - - - - - - - - ranking = 108347.92828896keywords = naevus, cell (Clic here for more details about this article) |
16/16. Malignant melanoma developing from an intradermal nevus.A 58-year-old man presented a black nodule with satellites located in the left upper region of the umbilicus. Clinical history and microscopic findings led us to diagnose it as a malignant melanoma developing from an intradermal nevus. Histopathologically, melanoma cells developed upward from the nest of the intradermal nevus and no junctional activity was shown. Cases of malignant melanoma arising from an intradermal nevus have rarely been reported. Moreover, previously reported cases showed melanoma cells beneath the intradermal nevus.- - - - - - - - - - ranking = 0.66666666666667keywords = cell (Clic here for more details about this article) |
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