1/3. Primary primitive neuroectodermal tumor (PNET) of the kidney: a case report.OBJECTIVES: Primary primitive neuroectodermal tumor (PNET) of the kidney is an extremely rare entity and the case is presented to highlight the histological diagnostic problems. methods AND RESULTS: A 23-year-old female presented with a lump in the left hypochondrium that had appeared 3 months, earlier, which suggested a malignancy on radiological investigation. The nephrectomy specimen revealed a large tumor mass with only a small portion of normal renal parenchyma. histology showed a small cell malignant tumor and the diagnosis of PNET (primary of kidney) and small cell carcinoma were suspected. The tumor showed NSE and vimentin positivity and cytokeratin negativity, which conformed with the diagnosis of PNET. CONCLUSION: The biological behaviour of PNET is more aggressive, with rapid progression and infiltration into the surrounding tissues and distant metastases. Thus it differs from the small renal cell malignancies and hence recognition of this tumor as a distinct entity is essential.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
2/3. Primary PNET of kidney: report of two cases and review of literature.PNET of the kidney is a rare tumor with only a few published reports. In view of poorer prognosis and different therapeutic approach, renal PNET should therefore be differentiated from other primary renal neoplasma such as wilms tumor, renal neuroblastoma and malignant rhabdoid tumor which on histology resemble renal PNET. Two cases of renal PNET have been described in this report. Cut surface of the tumor in both cases was greyish white lobulated, with multiple tiny cystic areas. Histologically, tumor consisted of loosely cohesive sheets of small to medium sized monomorphic cells with round nuclei and little cytoplasm. Tumor cells showed diffuse strong membrane positivity for MIC2 and focal weak to moderate positivity for NSE and vimentin. Renal PNET should therefore be included in differential diagnosis of rapidly enlarging renal lumps presenting with local infiltration and aggressive behaviour, particularly in children and young adults. Diffuse strong membrane positivity for MIC2 in PNET is helpful in differentiating it from other primary renal neoplasms.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
3/3. Intracerebral primitive neuro-ectodermal tumor (PNET).A case of intracerebral primitive neuro-ectodermal tumor (PNET) is presented. PNETs are rare, undifferentiated neoplasms occurring primarily in children and young adults. These tumors exhibit a highly malignant behaviour with a tendency to disseminate along the cerebrospinal fluid (CSF) pathways. Preoperative diagnosis is difficult, owing to the non-specific CT and MR appearances and to the rarity of this tumor. Our patient was 33 years old, which is uncommon. CT findings initially suggested an intracerebral hematoma. Later on, CT and MR findings were specific for a brain tumor and showed a solid, non-calcified invasive mass, with poor perilesional edema.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |