1/2. Hormone-dependent, aggressive angiomyxoma of the vulva.BACKGROUND: Aggressive angiomyxoma is a rare neoplasm of undetermined etiology that occurs mainly in the female vulva and perineum. It tends to recur but does not metastasize. This case report describes findings suggestive of the possible hormone dependency of this neoplasm. CASE: A 41-year-old gravid woman developed an aggressive angiomyxoma of the left vulva with growth apparently related to the length of the pregnancy. The neoplasm marked strongly for progesterone receptors by immunohistochemical methods but was estrogen-receptor negative. CONCLUSION: The growth of the neoplasm during pregnancy and the nuclear-positive staining for progesterone receptors suggest a possible hormone (progesterone) dependency for at least some cases of aggressive angiomyxoma.- - - - - - - - - - ranking = 1keywords = angiomyxoma (Clic here for more details about this article) |
2/2. Aggressive angiomyxoma of the vulva: expression of estroprogestinic receptors and follow-up.PURPOSE OF INVESTIGATION: To analyze aggressive angiomyxoma hormone-dependency. METHOD: Estroprogestinic receptor expression was studied by immunohistochemistry in 5 patients with aggressive angiomyxoma of the vulva. RESULTS: The immunohistochemical results confirm the positivity of angiomyxoma for estrogen and progesterone receptors. CONCLUSIONS: We hypothesized that the concomitant factor favoring neoplastic growth is a different genetic substrate specific in the female sex. Analysis of the data regarding the distribution of angiomyxomas in different age groups has strengthened this hypothesis suggesting that this tumor is correlated with complete maturity, in all probability hormonal. However it cannot be excluded that the tumor begins to develop at an early age, but since it has a slow growth rate, the phenomenon is delayed and is related to hormonal stimulation.- - - - - - - - - - ranking = 1.1428571428571keywords = angiomyxoma (Clic here for more details about this article) |