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1/4. Early spontaneous regression of a hypothalamic/chiasmatic mass in neurofibromatosis type 1: MR findings.

    A patient with neurofibromatosis type 1 was found to have an enhancing mass in the hypothalamus and in the anterior optic pathway. A 3-month MR study showed a reduction in the size and enhancement of the mass. At a 9-month MR follow-up the mass disappeared and ceased to enhance. This report shows the unusual behaviour of a hypothalamic/chiasmatic mass confirming that in such asymptomatic cases the conservative management can be considered the treatment of choice.
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2/4. Spontaneous regression of exostoses: two case reports.

    exostoses are a common skeletal disorder. Despite their incidence, little is yet known about their origin and biological behaviour. In particular, spontaneous regression of exostoses--an extremely rare event--is still a subject for debate. In this study, we describe two additional cases of spontaneous regression of exostosis; one was a solitary lesion while the other occurred in a patient with multiple heritable exostoses. Radiographic findings are presented along with some of the theories which aim at explaining this phenomenon.
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3/4. Maturing neuroblastoma and ganglioneuroblastoma: a study of four cases with long survival.

    A retrospective study of four tumours of the peripheral nervous system originally diagnosed as neuroblastomas or ganglioneuroblastomas has been made. The patients have all survived since the original diagnosis. Evidence of residual tumour was seen only in one patient, and was associated with evidence of increasing histological differentiation over a period of time. Maturation of primitive cell types is known to alter the prognosis of neuroblastic tumours. It is suggested first, that even minimal evidence of maturation indicates a better prognosis. Second, that evidence of maturation may be uneven, small areas occurring in otherwise totally undifferentiated tumours, or, immature areas remaining even in apparently benign fully mature tumours; if these areas show maturation the prognosis remains good and the tumour should not be confused with a composite ganglioneuroblastoma. Third, that maturing tumours may behave in a malignant fashion, invade and metastasise, but but with maturation of the primary tumour and its metastases the ultimate prognosis may be better than the initial behaviour suggests.
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4/4. Spontaneous caval tumor thrombus necrosis and regression of pulmonary lesions in renal cell cancer.

    Idiopathic regression of metastases is one of the features of the unpredictable behaviour of renal cell carcinoma. We report a patient with pulmonary metastases and a tumor thrombus in the inferior vena cava with spontaneous regression of the lung lesions and necrosis of the thrombus before any therapy was instituted.
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