1/9. Acute cardiomyopathy with rhabdomyolysis in chronic alcoholism.Of five chronic alcoholics with acute skeletal muscle necrosis (rhabdomyolysis) three developed acute heart failure with disturbances of rhythm and conduction. Symptoms came on abruptly after a period of intensified drinking. myocardial infarction, thiamine deficiency, and cobalt intoxication were excluded. Probably the whole spectrum of muscle disease in chronic alcoholism may be commoner than has been suspected.- - - - - - - - - - ranking = 1keywords = intoxication (Clic here for more details about this article) |
2/9. Acute myopathy associated with chronic licorice ingestion: reversible loss of myoadenylate deaminase activity.A patient with acute rhabdomyolysis and absence of myoadenylate deaminase (MADA) associated with chronic licorice intoxication is presented. Clinical and laboratory examination of the patient and morphologic study over skeletal muscle were performed. The major effect of licorice intoxication is hypokalemia, which may explain most of the observed clinical symptoms and morphological changes. The absence of MADA may be a consequence of the direct toxic effect of licorice glycosides. To our knowledge, this is the first report in which a lack of MADA and chronic licorice intoxication has been shown to be associated with clinical, histochemical, biochemical, and morphological changes, which were completely reversed with potassium supplementation and licorice withdrawal.- - - - - - - - - - ranking = 3keywords = intoxication (Clic here for more details about this article) |
3/9. Psoas muscle calcification and acute renal failure associated with nontraumatic rhabdomyolysis: CT features.We present a case of reversible psoas muscle calcification associated with acute renal failure and alcohol intoxication. The CT demonstration of calcification led to the recognition of rhabdomyolysis.- - - - - - - - - - ranking = 1keywords = intoxication (Clic here for more details about this article) |
4/9. germanium myopathy: clinical and experimental pathological studies.Pathological examinations were carried out on the skeletal muscle of a patient with germanium intoxication. The prominent histochemical finding was vacuolar myopathy with lipid excess, increased acid phosphatase activity and decreased cytochrome c oxidase activity. Ultrastructural lesions revealed a mitochondrial abnormality, autophagic vacuoles and accumulation of high electron-dense materials in deformed mitochondria and at the periphery of lipid droplets. Furthermore, the toxic effect of germanium on skeletal muscle was confirmed by the experimentally induced germanium myopathy, which showed autophagic degeneration, decreased cytochrome c oxidase activity and a mitochondrial abnormality with high electron-dense materials.- - - - - - - - - - ranking = 1keywords = intoxication (Clic here for more details about this article) |
5/9. Myopathy of chronic organophosphate poisoning: a clinical entity?The acute aspects of organophosphate poisoning are well understood. Persistent weakness and muscular wasting in some cases have been attributed to neuropathic effects resulting in muscular atrophy from denervation. Recently, necrosis of skeletal muscle has been induced by chronic inhibition of cholinesterase with organic phosphates in a reproducible experimental model. The literature on organophosphate poisoning in man alludes to cases in which it appears plausible to postulate this mechanism as a cause of a residual myopathy. A new case in which chronic organophosphate intoxication may be implicated in the etiology of a proximal myopathy is presented. Reports of additional cases, followed up from the onset of symptoms, are needed to determine whether primary myopathic effects are a clinically significant complication of chronic organophosphate poisoning.- - - - - - - - - - ranking = 1keywords = intoxication (Clic here for more details about this article) |
6/9. Neuromyopathy of cyanide intoxication due to "laetrile" (amygdalin). A clinicopathologic study.A 67-year-old woman with lymphoma presented with a neuromyopathy following "laetrile" (amygdalin) treatment. She had significant elevation of blood and urinary thiocyanate and cyanide levels. sural nerve biopsy specimen revealed a mixed pattern of demyelination and axonal degeneration, the latter being prominent. Gastrocnemius muscle biopsy specimen showed histochemically a mixed pattern of denervation and myopathy with Type II atrophy. It is concluded that cyanide toxicity secondary to laetrile therapy and nutritional deficiency caused the neuromyopathy, as the changes in peripheral nerve are similar to changes described in ataxic polyneuropathy occurring in nigeria attributed to high cyanide content in the diet and nutritional deficiency. Although this patient received vincristine initially, the development of the neuromyopathy had no temporal relationship to its administration. The clinical profile, as well as peripheral nerve and muscle changes were not similar to either vincristine neuromyopathy or neuromyopathy due to paraneoplastic manifestation of lymphoma. Clinical improvement following discontinuation of "laetrile" by the patient further supports the toxic etiologic results for the neuromyopathy in this patient.- - - - - - - - - - ranking = 4keywords = intoxication (Clic here for more details about this article) |
7/9. Inorganic mercury intoxication reminiscent of amyotrophic lateral sclerosis.Two employees in a mercuric oxide manufacturing plant developed neurologic changes not previously reported from the exposure to inorganic mercury or elemental mercury vapor. The symptoms, physical findings and laboratory studies resembled those found in amyotrophic lateral sclerosis (ALS) and organic mercury intoxication. Nineteen employees are reported who precipitously developed signs and symptoms which may be regarded to be the early onset of a symptom complex of mercury intoxication that would likely have progressed to the ALS-like syndrome if the progression had not been interrupted by removal of the individuals from exposure to mercury. All symptoms, signs, and laboratory findings returned completely to normal after approximately three months in a mercury free work environment.- - - - - - - - - - ranking = 6keywords = intoxication (Clic here for more details about this article) |
8/9. Neurological complications of ethylene glycol intoxication. Report of a case.A 29-year-old man suffered bilateral facial nerve paralysis, dysarthria, dysphagia, ataxia, visual deterioration, and internal ophthalmoplegia after ethylene glycol ingestion.- - - - - - - - - - ranking = 4keywords = intoxication (Clic here for more details about this article) |
9/9. rhabdomyolysis and acute renal failure associated with phencyclidine intoxication.rhabdomyolysis can occur with phencyclidine hydrochloride (PCP) intoxication. However, to our knowledge acute renal failure with phencyclidine-induced rhabdomyolysis has not been reported previously. Therefore, we describe two patients with this condition. The modern treatment of phencyclidine intoxication, namely aggressive acidification and diuretic therapy, can enhance the risk of acute renal failure in patients with rhabdomyolysis. Therefore, exclusion of rhabdomyolysis is essential before acidification measures are undertaken.- - - - - - - - - - ranking = 6keywords = intoxication (Clic here for more details about this article) |