Cases reported "Menopause, Premature"

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1/8. Cyclic therapy resulted in pregnancy in premature ovarian failure.

    A successful pregnancy in a patient with premature ovarian failure is described. Increased serum gonadotropin titers, decreased serum estrogen levels, and lack of ovarian follicles on histologic examination confirmed the state of ovarian failure. The patient conceived after several courses of cyclical treatment with estrogen-progestin. A possible relationship between the estrogen treatment and subsequent pregnancy is discussed.
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2/8. ovulation induction and pregnancy with an estrogen-gonadotropin stimulation technique in a menopausal woman with marked hypoplastic ovaries.

    A case is described of a woman with ovarian failure and documented atrophic ovaries in whom ovulation was achieved with the use of high-dose estrogen and human menopausal gonadotropins. The proposed mechanism involves a reduction in the elevated gonadotropins, which restored an adequate number of receptors. Thus sensitivity to exogenous menotropins was reestablished.
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3/8. ovum donation by sisters in ovarian failure: simplified priming and early withdrawal of exogenous support.

    Two cases of successful pregnancy and delivery by patients with ovarian failure are reported. In both cases ova were donated by the sister of the patient. A high degree of success (two pregnancies in three attempts) is discussed, as is the significance of simplified pretransfer "priming" and very early withdrawal of exogenous hormonal support.
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4/8. Estrogen treatment and subsequent pregnancy in two patients with severe hypergonadotropic ovarian failure.

    The history, diagnosis and management of two patients with premature ovarian failure who responded to estrogen replacement therapy is presented. Both women conceived and had a live healthy baby.
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5/8. pregnancy in a patient with gonadotropin-resistant ovary syndrome.

    The case of a patient with gonadotropin-resistant ovary syndrome is discussed. Ovulation was successfully induced by the administration of human chorionic gonadotropin and by estrogen replacement therapy. A total of three pregnancies occurred. The first two pregnancies resulted in blighted ova. The third pregnancy resulted in a normal term delivery.
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6/8. pregnancy in three patients with hypergonadotropic ovarian failure.

    The authors present three women with early hypergonadotropic ovarian failure. In one patient autoimmune aetiology of the disease was suggested by the co-existing Addison's disease and idiopathic hypothyroidism. In the other two women the causes of hypogonadotropic amenorrhea remained unclear. All three women were delivered of normal children: one after two spontaneous pregnancies and the other two after a pregnancy induced by short-term estrogen therapy.
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7/8. Case report. Successive pregnancies in a patient with premature ovarian failure.

    A woman, age 28 yr, visited the gynecological endocrine clinic for oligomenorrhea and primary infertility. serum FSH and LH levels were high and estrogen concentrations were subnormal. In spite of the presence of high and sustained gonadotropin concentrations, resumption of ovarian function with evident ovulation resulted in the first pregnancy after clomiphene therapy. Four years later the patient did not respond to clomiphene but intramuscular progesterone was effective in induction of ovulation, followed by the second pregnancy. The effect of progesterone on hypergonadotropic ovarian failure is discussed.
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8/8. Oestrogen treatment and subsequent pregnancy in two patients with severe hypergonadotrophic ovarian failure.

    This report describes in detail the histological and hormonal findings in a patient with Turner's syndrome (45,XO) and a patient with premature menopause (46,XX), who both conceived after withdrawal or reduction of substitution therapy with oestrogens. The aetiology of severe hypergonadotrophic ovarian failure is discussed, and theories regarding a possible relationship between the oestrogen treatment and subsequent pregnancy are hypothesized.
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