1/5. granulomatous mastitis in pregnancy.BACKGROUND: granulomatous mastitis, a rare, benign breast condition characterized by granulomas and abscess formation, is mistaken frequently for inflammatory breast carcinoma. Although it has been reported in reproductive-age women, it is unusual in pregnancy. CASE: A 25-year-old black gravida 4 para 2 developed a tender, indurated 20 x 15 x 15 cm multilobulated breast mass at 17 weeks' gestation. After not responding to antibiotics and incisional drainage, the biopsy-proved granulomatous mastitis improved with corticosteroid treatment. A postpartum recurrence also responded to steroid therapy. CONCLUSION: granulomatous mastitis is diagnosed clinically and histologically. Early recognition and initiation of steroid treatment might prevent repetitive, deforming breast biopsies.- - - - - - - - - - ranking = 1keywords = pregnancy (Clic here for more details about this article) |
2/5. Primary tuberculous mastitis in a Nigerian woman.Tubercolous mastitis is an uncommon lesion even in countries where the incidence of pulmonary and extrapulmonary tuberculosis is still very high. At the Ife University teaching Hospital only one case of tuberculous mastitis has been seen over a ten-year period during which 671 breast biopsies were examined. This was in a 36-year old Nigerian woman who developed a left breast mass during pregnancy. She was seen after her delivery and was initially diagnosed as a case of carcinoma of the breast. Subsequent excisional biopsy and pathological examination of the mass confirmed tuberculosis of the breast. She has responded favourably to anti-tuberculous therapy.- - - - - - - - - - ranking = 0.2keywords = pregnancy (Clic here for more details about this article) |
3/5. Antepartum mastitis. A report of two cases.Antepartum mastitis is uncommon during pregnancy. This report describes two cases of mastitis occurring at 32 and 34 weeks' gestation. Early, aggressive therapy with parenteral antibiotics, as used in these cases, maximizes breast tissue conservation and function, avoids the development of breast abscesses and reduces both maternal and fetal morbidity.- - - - - - - - - - ranking = 0.2keywords = pregnancy (Clic here for more details about this article) |
4/5. salmonella bredeney mastitis during pregnancy.A young woman developed mastitis due to salmonella bredeney during the 25th week of her first pregnancy and recovered with ampicillin therapy. Unusual microorganisms occasionally cause breast disease. Material for Gram stain, cultures, and susceptibility studies should be obtained before treatment in all cases.- - - - - - - - - - ranking = 1keywords = pregnancy (Clic here for more details about this article) |
5/5. A survivor of breast cancer with immunity to MUC-1 mucin, and lactational mastitis.The human mucin, MUC-1, is a transmembrane glycoprotein that is produced by both normal an malignant epithelium. The MUC-1 produced by malignant epithelium is underglycosylated, which leads to the expression by tumors of novel T and B cell epitopes on the mucin polypeptide core. Similar underglycosylation occurs in the lactating breast. In this report, we describe a long-term survivor of breast cancer whose tumor strongly expressed the T- and B-cell-stimulatory epitopes. Five years after presenting with the tumor, the patient had her first pregnancy, at which time she developed fulminant lymphocytic mastitis. We demonstrate that the lactating breast produced mucin expressing the same "tumor-specific" epitopes as the original cancer. The patient had circulating anti-mucin antibodies of both the IgM and IgG isotypes (these are not found in normal controls), and mucin-specific cytotoxic T lymphocytes in the peripheral blood. Limiting-dilution analysis for mucin-specific cytotoxic T lymphocytes in three different experiments yielded frequencies of 1 in 3086, 1 in 673, and 1 in 583, compared to approximately 1 in 10(6) in normal controls. The patient remains clinically free of carcinoma after 5 additional years of follow-up. We propose that the original tumor primed the patient's immune response against the mucin epitopes, and that the re-expression of these epitopes on the lactating breast evoked a secondary immune response. It is tempting to speculate that the vigor of her anti-mucin immunity may have helped protect this patient against recurrent tumor.- - - - - - - - - - ranking = 0.2keywords = pregnancy (Clic here for more details about this article) |