1/174. Dystrophic calcinosis cutis in subacute lupus.Dystrophic calcinosis cutis is known to be associated with various connective tissue disorders but to the best of our knowledge has never been reported in subacute cutaneous lupus erythematosus (SCLE), a distinctive cutaneous subset in the spectrum of lupus erythematosus. It occurs without calcium and phosphorus metabolic abnormalities and may be localized or generalized. We report a patient with SCLE who developed calcinosis cutis and had normal serum calcium and phosphorus levels and, interestingly, a normal concentration of blood ionized calcium. This latter, which represents the active form in the total amount of blood calcium, is a parameter only rarely assessed in patients with dystrophic calcinosis cutis. Thus, other pathogenic factors should be investigated to clarify the pathophysiology of the dystrophic type of calcification.- - - - - - - - - - ranking = 1keywords = lupus erythematosus, erythematosus, lupus (Clic here for more details about this article) |
2/174. Rowell's syndrome.Rowell's syndrome is the name given to a distinct group of patients with lupus erythematosus who develop erythema multiforme-like lesions and have a characteristic serological picture. We report a case of a 29-year-old woman of Afro-Caribbean origin who presented with an erythema multiforme-like eruption on the hands. Subsequently she developed painful erythematous swellings on the feet and scaly plaques on the forearm and thigh consistent with subacute cutaneous lupus. She developed a positive antinuclear factor and had positive anti-Ro and anti-La antibodies and a positive rheumatoid factor. All of these features are consistent with Rowell's syndrome which we believe is a rare but distinct variant of cutaneous lupus erythematosus.- - - - - - - - - - ranking = 0.9149862874862keywords = lupus erythematosus, erythematosus, lupus (Clic here for more details about this article) |
3/174. A case of SLE with acute, subacute and chronic cutaneous lesions successfully treated with dapsone.We describe a patient with systemic lupus erythematosus (SLE) who exhibited severe cutaneous involvement characterized by the simultaneous presence of acute, subacute and discoid lesions in association with anti-S1 antibodies. After she failed to respond to chloroquine, medium to low dose steroids, steroid pulses, retinoids and cyclophosphamide, the patient was treated with dapsone and a dramatic improvement in the cutaneous lesions was seen after only one month.- - - - - - - - - - ranking = 0.4437133600943keywords = lupus erythematosus, erythematosus, lupus, systemic lupus erythematosus, systemic lupus (Clic here for more details about this article) |
4/174. Linear cutaneous lupus erythematosus in an adult.We report on a 32-year-old female with a 3-year history of an asymptomatic erythema of the forehead. The lesion had a linear distribution following the lines of Blaschko. Histopathological findings and direct immunofluorescence allowed to establish the diagnosis of cutaneous lupus erythematosus. Treatment with local corticosteroid and antimalarial agents given for 2 months resulted in a complete remission.- - - - - - - - - - ranking = 2.2166209582873keywords = lupus erythematosus, erythematosus, lupus (Clic here for more details about this article) |
5/174. Rapid onset monoclonal gammopathy in cutaneous lupus erythematosus: interference with complement c3 and C4 measurement.Accurate nephelometric immunoassay requires both the analyte and the calibration standard to have the same molecular mass. Alteration in the size of the analyte can affect light scatter and yield erroneous results. We report a case where an autoantibody, a monoclonal IgM with immunoconglutinin activity, interfered with the nephelometric quantitation of plasma complement components C3 and C4.- - - - - - - - - - ranking = 1.7732967666299keywords = lupus erythematosus, erythematosus, lupus (Clic here for more details about this article) |
6/174. Extracorporeal photochemotherapy in cutaneous lupus erythematosus.We report two female subjects with therapy-resistant cutaneous lupus erythematosus (LE), one with subacute cutaneous and the other chronic discoid LE, both treated with extracorporeal photochemotherapy (ECP). The responses after six and eight cycles of ECP led to a prolonged remission of 18 and 11 months, respectively. ECP seems to be a treatment option for patients not responding to or showing unwanted side-effects during conventional standard therapy.- - - - - - - - - - ranking = 2.2166209582873keywords = lupus erythematosus, erythematosus, lupus (Clic here for more details about this article) |
7/174. Lupus erythematosus vegetans.A 29-year-old woman with known systemic lupus erythematosus presented with exudative and vegetative plaques bilaterally on her groins. The clinical and histological findings indicated a diagnosis of pyodermatitis vegetans. Direct immunofluorescence studies revealed the presence of a definite basement membrane zone band for IgG, IgM and C3, favouring lupus erythematosus. We propose the term lupus erythematosus vegetans for this combination of clinicopathological and immunohistological findings.- - - - - - - - - - ranking = 1.8845541760809keywords = lupus erythematosus, erythematosus, lupus, systemic lupus erythematosus, systemic lupus (Clic here for more details about this article) |
8/174. Subacute cutaneous lupus erythematosus presenting with generalized poikiloderma.A 64-year-old woman experienced progressive generalized poikiloderma after an episode of sunburn 4 years earlier. The diagnosis of subacute cutaneous lupus erythematosus (SCLE) was confirmed by the presence of anti-Ro/SS-A and antinuclear antibodies, the histology, and the direct immunofluorescent findings (ie, positive lupus band test and "dust-like" epidermal IgG staining pattern). Poikiloderma has not been previously reported in the spectrum of SCLE. As a major pathomechanism of SCLE, photosensitivity might explain this uncommon clinical manifestation of the disease.- - - - - - - - - - ranking = 2.2449588624586keywords = lupus erythematosus, erythematosus, lupus (Clic here for more details about this article) |
9/174. Long-term cefuroxime axetil in subacute cutaneous lupus erythematosus. A report of three cases.BACKGROUND: Subacute cutaneous lupus erythematosus (SCLE) is a subset of lupus erythematosus characterized mainly by prominent photoaggravated cutaneous manifestations. Standard therapies for SCLE include topical or systemic steroids and antimalarial drugs. Both methods show limited efficacy in clearing cutaneous lesions and occasionally produce serious side effects. AIM: To assess the efficacy of cefuroxime axetil, an oral cephalosporin with antibacterial and immunosuppressive activity, in patients with SCLE. methods: Three patients with SCLE were treated with cefuroxime axetil at a daily dose of 500 mg for 30-60 days. RESULTS: In all patients complete clearing of skin lesions was achieved and no side effects were observed. CONCLUSION: We suggest that long-term cefuroxime axetil administration might be an alternative treatment for patients with SCLE skin lesions.- - - - - - - - - - ranking = 2.6599451499448keywords = lupus erythematosus, erythematosus, lupus (Clic here for more details about this article) |
10/174. Linear eruptions of the nose in childhood: a form of lichen striatus?We report four children with linear eruptions on the nose, with overlapping features of lichen striatus and linear cutaneous lupus erythematosus. However, linear lupus erythematosus has rarely been reported, and lichen striatus, although classically linear, rarely affects the face. The linear distribution of lesions from the glabella to the ala nasi may represent distribution following Blaschko's lines.- - - - - - - - - - ranking = 0.88664838331494keywords = lupus erythematosus, erythematosus, lupus (Clic here for more details about this article) |
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