1691/8157. A very rare localization of metastatic lung carcinoma to the interosseous membrane. INTRODUCTION: Soft tissue is a rare localization of carcinoma metastasis. Skeletal muscle is considered the most frequent site. The aim of this paper is to report a very rare localization of soft-tissue metastasis of lung adenocarcinoma in the lower leg interosseous membrane, surgically treated at our department. MATERIALS AND methods: A 66-year-old man with a history of lung adenocarcinoma was admitted to our department because he complained of a pain resistant to drugs that had persisted for 1 month. Imaging showed that the lesion was unique, localized in the interosseous membrane, with a distal margin more than 2 cm above the ankle platform. A distal fibula resection, including the tumour and a reconstruction according to Capanna type A2 was performed. RESULTS: At the 6 months follow-up, the patient was walking without external support. CONCLUSION: Surgery is not the treatment of choice for soft-tissue metastases, but it may be recommended when the lesion is unique and inducing a pain resistant to anti-inflammatory drugs. ( info) |
1692/8157. Sclerosing hemangioma of the lung. A well circumscribed nodular mass discovered on routine chest ray examination, in the left inferior lobe of an otherwise healthy 49-year-old male. Histopathologically the lesion corresponded to a typical so called sclerosing hemangioma. The clinical and histopathological features are described. The sclerosing hemangioma of the lung is a rare benign tumor. Its histogenesis has not been explained yet. Following the electron-microscopic and immunohistochemical researches the opinions have been still unhomogeneous. Therefore, it is concluded that is a tumor of epithelial, endothelial, mesenchymal and even mesothelial origin. This study deals with this tumor, its immunohistochemical analysis points at its epithelial character. ( info) |
1693/8157. Pulmonary capillary hemangiomatosis with severe pulmonary hypertension. Pulmonary capillary hemangiomatosis (PCH) is a rare idiopathic lung disorder that occurs in young patients and leads to pulmonary hypertension (PH). It is difficult to diagnosis in the early stage and is often mistaken for primary PH; in almost all cases of PCH, the correct diagnosis is not made until autopsy. In the present case of PCH, the patient had severe pulmonary hypertension and died of respiratory failure. Pathologically, PCH is characterized by proliferation of benign thin-walled capillary sized blood vessels in the lung parenchyma. ( info) |
1694/8157. An unusual cause of an incidental lung mass. A 52-year-old woman was found to have a mass measuring 1 cm in diameter with radiographic features of a carcinoid tumour in the left lung during work-up for chest pain. Wedge excision of the lesion revealed a leiomyoma that had a similar histological appearance to uterine 'fibroids' removed eight years previously. This case is an example of benign metastasizing leiomyoma, an unusual lesion of uncertain etiopathogenesis. ( info) |
1695/8157. Paraneoplastic sensory neuronopathy and spontaneous regression of small cell lung cancer. BACKGROUND: Spontaneous tumour regression in small cell lung cancer has previously been suggested in patients with paraneoplastic neurologic syndromes. Rare documentation of this event has occurred in the literature. CASE REPORT: The authors report a patient with anti-Hu associated paraneoplastic sensory neuronopathy who had a spontaneous regression of her small cell lung cancer. CONCLUSIONS: This case supports the hypothesis that anti-Hu neurologic syndromes are the consequence of a misdirected immune response to small cell tumours. ( info) |
1696/8157. Sclerosing hemangioma of the lung with cystic appearance. A case of cystic sclerosing hemangioma of the lung is reported. A chest X-ray of a 55-year-old woman who had been suffering from a cough with sputum for several months revealed an abnormal nodular shadow. A chest CT scan revealed a solitary tumor with cystic appearance occupying S7 of the right lung and the inferior pulmonary ligament. Radiological differential diagnosis for the lesion included bronchogenic cyst, cystic Schwannoma, pulmonary necrotic carcinoid, and lung carcinoma. Right lower lobectomy was carried out and the lesion was pathologically diagnosed as sclerosing hemangioma of the lung with cystic features, expanding into the pulmonary ligament. Differential diagnosis of the cystic lesion of the lung should include cystic sclerosing hemangioma as observed in this case. ( info) |
1697/8157. Malignancy risk in patient with neurofibromatosis and autosomal dominant polycystic kidney disease. Cancer appearance in some inherited diseases depends on the interactions with other genes. lung cancer is rare in neurofibromatosis and has not been reported in Caucasian population. In this paper, we present the case of lung adenocarcinoma in a patient with neurofibromatosis, pseudoarthrosis of tibia, and autosomal dominant polycystic kidney disease. cytogenetic analysis of the pleural effusion showed chaotic cleavage and constitutional inversion of chromosome 9, transmitted from the mother. family investigation revealed two autosomal dominant diseases, neurofibromatosis and polycystic kidney disease in the same family. These findings suggest that the second autosomal dominant disease in the family and inversion of chromosome 9 contributed to the severity of neurofibromatosis and patient's risk to malignancies. ( info) |
1698/8157. Lymphoepithelioma-like carcinoma of the lung in a patient with silicosis. silicosis is an important form of pneumoconiosis, which is caused by significant exposure to crystalline silica. The carcinogenicity of silica, despite traditional beliefs, in relation to lung cancer has been controversial. Lymphoepithelioma-like carcinoma of the lung, an Epstein-Barr virus-associated undifferentiated carcinoma, is a rare entity of pulmonary malignancy, which tends to affect young nonsmoking Asians. The first case of silicosis, initially complicated by pulmonary tuberculosis, which later developed into advanced lymphoepithelioma-like carcinoma of the lung is reported. A combination of 5-fluorouracil, cisplatin and calcium folinate resulted in partial tumour response. ( info) |
1699/8157. Nail toxicity related to taxanes. A 70-year-old woman with non-small-cell lung cancer developed severe nail toxicity while she was being treated with docetaxel at three-week intervals. Docetaxel is a chemotherapeutic agent of the taxane family. Taxanes are well known to cause nail changes, but mainly when used on a weekly basis. ( info) |
1700/8157. Numerous asymptomatic facial papules and multiple pulmonary cysts: a case of birt-hogg-dube syndrome. birt-hogg-dube syndrome (BHDS) is a rare genodermatosis with cutaneous and systemic findings. We report the case of a 47-year-old woman with BHDS who presented with numerous facial papules and the more recently associated finding of pulmonary cysts. We review recent genetic discoveries and the cutaneous and systemic findings associated with this rare syndrome. ( info) |