1/32. leukoplakia of the anal canal.Two cases of leukoplakia of the anal canal are presented, with illustrations of the typical gross and microscopic appearance. The lesions were asymptomatic, and were discovered by routine rectal examination. Histological findings included hyperkeratosis and acanthosis extending cephalad from the anal verge to the dentate line. Followup after 3 and 15 years revealed no evidence of dysplastic changes, and a review of the literature did not uncover any reported cases with dysplasia or with documented evolution to malignancy. There is little evidence that leukoplakia of the anal canal is premalignant but patients should be followed carefully, since the natural history of this rare lesion is unknown.- - - - - - - - - - ranking = 1keywords = leukoplakia (Clic here for more details about this article) |
2/32. leukoplakia of the urinary tract: a review.We herein describe 44 new cases of leukoplakia of the renal pelvis, bladder and urethra. leukoplakia is uncommon. It occurs twice as often in the bladder as in the pelvis and ureter and it is associated with and perhaps caused by chronic infection. carcinoma is present in 10 to 20 per cent of the cases at diagnosis. We believe that leukoplakia is not simple squamous metaplasia but a step further down the line--a process that evolved through squamous metaplasia and perhaps could result in cancer. We think leukoplakia is potentially pre-malignant and it should be treated as a low grade and low stage tumor since no satisfactory treatment exists.- - - - - - - - - - ranking = 1.5keywords = leukoplakia (Clic here for more details about this article) |
3/32. Management of extensive leukoplakia of bladder.A case of extensive leukoplakia of the bladder is presented. The occurrence is unusual and the management controversial. cystectomy should be considered in men with extensive vesical leukoplakia.- - - - - - - - - - ranking = 3keywords = leukoplakia (Clic here for more details about this article) |
4/32. Ocular surface squamous neoplasia: report of an unusual case and review of the literature.OBJECTIVE: To describe a case of leukoplakia and underlying intraepithelial squamous cell neoplasia of the palpebral conjunctiva presenting in a patient wearing an ocular prosthesis. methods: The clinical presentation, histopathological findings and surgical outcome are described in a 62-year-old man in whom leukoplakic lesions of the palpebral conjunctiva in a socket fitted with an ocular prosthesis were noted in addition to squamous cell carcinoma of the lower lid skin. RESULTS: Histopathological examination revealed islands of squamous cell carcinoma in the skin lesion and squamous cell carcinoma-in-situ in the leukoplakic conjunctival specimen. Successful tumour excision and lid reconstruction were performed. CONCLUSION: This report highlights the successful treatment of long-standing conjunctival squamous cell carcinoma-in-situ associated with an ocular prosthesis and a general tendency to pre-neoplastic lesions of the skin. Regular examination of the sockets of patients wearing long-standing ocular prostheses is recommended.- - - - - - - - - - ranking = 0.5keywords = leukoplakia (Clic here for more details about this article) |
5/32. Prostatic urethral leukoplakia with prostatic abscess.We present a case of prostatic abscess and coexistent leukoplakia of the urethra in a 51-year-old man. He had been suffering from diabetes mellitus for 10 years and following cessation of high fewer, transurethral electrovaporesection was performed.- - - - - - - - - - ranking = 2.5keywords = leukoplakia (Clic here for more details about this article) |
6/32. Extensive bilateral renal pelvis, ureter and bladder leukoplakia.We are presenting a case of leukoplakia spread to the bilateral renal pelvis, ureter and bladder in a 52-year-old woman. We believe this case is important because it involves leukoplakia that is more extensive than in any cases previously cited in the literature. No other possible etiologic cause except a heavy smoking habit was defined. Conservative follow-up was preferred to aggressive surgery.- - - - - - - - - - ranking = 3keywords = leukoplakia (Clic here for more details about this article) |
7/32. Oral-dental findings in dyskeratosis congenita.A 13-yr-old girl with dyskeratosis congenita is presented. Besides oral leukoplakia and nail dystrophies, there was evidence of pancytopenia, growth retardation, alopecia, mental retardation and microcephaly. The oral findings included caries, gingival recession, short-blunted roots, gingival bleeding, tooth mobility and severe alveolar bone loss resembling juvenile periodontitis.- - - - - - - - - - ranking = 0.5keywords = leukoplakia (Clic here for more details about this article) |
8/32. A case of lichen planus of the penis mimicking leukoplakia lesions: a review of differential diagnosis.We describe a case of a 50-year-old man with lesions localized in the region of urethral meatus and on the epithelium of the foreskin. The lesions were observed as the white spots with flat or somewhat depressed surface, locally similar to leukoplakia, lichen sclerosus atrophicus or cicatrix, without any subjective symptoms. cystoscopy, micturition urography and biopsy were performed by urologist. The diagnosis of lichen planus Wilsoni was made based on the biopsy examination. We obtained great improvement of lesions through the applied local therapy- - - - - - - - - - ranking = 2.5keywords = leukoplakia (Clic here for more details about this article) |
9/32. dyskeratosis congenita vs. chronic graft versus host disease: report of a case and a review of the literature.dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome characterized by the triad of reticular pigmentation of the skin, nail dystrophy, and mucosal leukoplakia. DC is often associated with severe pancytopenia, and bone marrow failure is the principal cause of early mortality. Malignant transformation of mucosal leukoplakias may also occur. Rarely, aplastic anemia precedes the other clinical manifestations of the disease. We present a case of a 13-year-old boy who was diagnosed at age four with idopathic aplastic anemia, was treated successfully with an allogeneic bone marrow transplant, then subsequently developed skin, nail, and tongue lesions. While the initial impression was chronic graft-versus-host disease, additional work-up confirmed the diagnosis of DC.- - - - - - - - - - ranking = 1keywords = leukoplakia (Clic here for more details about this article) |
10/32. Exacerbation of oral erosive lichen planus by combination of interferon and ribavirin therapy for chronic hepatitis c.hepatitis c virus (HCV) induces extrahepatic manifestations such as oral lichen planus (OLP) as well as chronic liver diseases. The treatment of HCV-related chronic liver disease has evolved from the use of a single agent, mainly interferon (IFN), to the combination of IFN and ribavirin. We present a case of erosive OLP, cutaneous lichen planus (CLP), and leukoplakia of the vocal cord in a man with chronic hepatitis c infection treated with IFN and ribavirin. A 65-year-old man suffered from OLP before undergoing combination of IFN and ribavirin therapy for chronic hepatitis c. He was initially treated with IFNbeta (6 million units (MU) /day for 2 weeks), then a combination of IFNalpha-2b (6 MU/day for 2 weeks and 3 times a week for 14 weeks) and ribavirin (400-600 mg/day). The OLP lesion was not aggravated by application of steroids during the 7 weeks after the treatment, but after 18 weeks, the combination of IFN and ribavirin was stopped because of aggravation of the OLP. Elevated aminotransferase levels returned to normal during the therapy. But 7 weeks after discontinuation, aminotransferase levels rose to 10 times the normal range. Five months after discontinuation, the papules of CLP appeared. Eight months after discontinuation, the OLP erosion had gradually reduced, but some erosion remained. Aminotransferase levels were decreased, but serum HCV rna had not disappeared. Caution should be exercised when IFN or ribavirin therapy is given to chronic hepatitis c patients with prior erosive OLP.- - - - - - - - - - ranking = 0.5keywords = leukoplakia (Clic here for more details about this article) |
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