1/3. Oral hairy leukoplakia in an HIV-negative woman with Behcet's syndrome.The first case of oral hairy leukoplakia in an HIV-negative patient with Behcet's syndrome is reported. The patient was a 47-year-old woman with bilateral lesions on the tongue. The clinic and histologic appearances were typical of hairy leukoplakia, and Epstein-Barr virus was demonstrated in the epithelial cells by dna in situ hybridization. The patient had been on systemic steroid therapy for 15 years to control lesions of Behcet's syndrome. The literature now records 30 HIV-negative patients with hairy leukoplakia.- - - - - - - - - - ranking = 1keywords = hybridization (Clic here for more details about this article) |
2/3. Hairy leucoplakia and hiv-2--a case report and review of the literature.Type 2 human immunodeficiency virus (hiv-2), originally confined to West africa, has lately appeared with increasing frequency in europe. Oral lesions affect a large proportion of patients with AIDS. Hairy leucoplakia (HL), a clinical expression of Epstein-Barr virus (EBV), is a lesion of the oral mucosa (usually the lateral margin of the tongue) that is observed in patients who are immunocompromised due to HIV or, more rarely, due to immunosuppressive medication or other causes. We review the definition, clinical signs, histopathology, diagnosis, prognosis and treatment of HL, and report the (to our knowledge) first detailed description of an hiv-2-seropositive patient with HL, which affected the lateral and dorsal tongue and was the first clinical sign of HIV infection (this patient was at that time only the second native Spaniard in whom unique hiv-2 infection had been detected). EBV detection and subtyping by in situ hybridization and polymerase chain reaction were performed in paraffin-embedded tissue from the HL lesion of the dorsal tongue; EBV-1 and EBV-2 were detected by the latter technique.- - - - - - - - - - ranking = 1keywords = hybridization (Clic here for more details about this article) |
3/3. Pseudo oral hairy leukoplakia in a renal allograft recipient.Oral hairy leukoplakia (OHL) is a disorder of the tongue associated with Epstein-Barr virus (EBV). OHL is seen mainly in HIV infection but is also rarely seen in the course of iatrogenic immunosuppression, especially in kidney transplantation; OHL is even more rarely seen in immunocompetent hosts. Lesions that clinically and histologically mimicked OHL but were not associated with EBV were recently characterized as pseudo hairy leukoplakia. We present such a case that occurred in a renal allograft recipient; light and electron microscopy, immunohistochemistry, and in situ hybridization were used to examine the patient for the presence of EBV and human papillomavirus. Two independent treatments with topical retinoid and oral amoxicillin resulted in complete remission. Pseudo hairy leukoplakia may correspond, at least in some cases, to the conditions known as leukoedema and white sponge nevus; the distinction of these diseases from OHL is of importance because OHL is a hallmark of severe immunosuppression.- - - - - - - - - - ranking = 1keywords = hybridization (Clic here for more details about this article) |