1/7. Atypical (bizarre) leiomyoma of the nasal cavity with prominent myxoid change.A 72 year old woman presented complaining of nasal obstruction, rhinorrea, and epistaxis. At examination, a polypoid mass on the right posterior choana was revealed and subsequently removed. light microscopic findings consisted of a diffuse proliferation of spindle shaped, pleomorphic cells with eosinophilic cytoplasm and blunt ended nuclei in a prominent myxoid background. The presence of numerous plurinucleate, bizarre cells made it very difficult to determine the malignant potential. Immunohistochemical evidence for leiomyogenic markers coupled with the low mitotic rate, the lack of an infiltrating growth pattern, and the indolent clinical course led to the diagnosis of atypical leiomyoma with prominent myxoid change. A literature survey confirmed that such a tumour is extremely rare at this site, but the biological behaviour seems to be similar to its uterine counterpart. Clinicians should be aware of this occurrence to prevent misdiagnosis because a conservative therapeutic approach is necessary in this disease.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
2/7. Development of leiomyosarcoma from primary leiomyoma?kidney leiomyosarcoma represents a rare variety of malignant kidney tumours. In this paper, we report on a patient with an inoperable leiomyosarcoma. Since this neoplasm is very rare, there is very little information on this type of malignancy. We present the symptoms, radiological findings, diagnostic criteria and differential diagnosis of the tumour. leiomyosarcoma exhibits aggressive biological behaviour and has a poor prognosis. We have found that the treatment of choice is a radical nephrectomy.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
3/7. A rare case of solitary fibrous tumour of the pre-sacral space: morphological and immunohistochemical features.A 28-year-old woman presented with abdominal pain. Ultrasonograhic examination showed a pre-sacral mass, with complex structure and well delimitated cystss with thick walls. The resected specimen was 7.5 x 6 x 4 cm in size, well circumscribed and yellow in colour, with cysstic change containing mucoid-like material. Histologically, the lesion was composed of spindle cells with high cellularity and rich vascularization with a haemangiopericytoma-like pattern. The diagnosis of solitary fibrous tumour (SFT) was made. The differential diagnosis for SFT of the pre-sacral spaace involves haemangiopericytoma, GIST, malignant mesothelioma, synovial sarcoma, leiomyomatous tumours and granulosa cell tumour. Immunohistochemical studies revealed reactivity for CD34, CD99 and Bcl-2, but no staining for desmin, inhibin, c-kit, EMA, CK, SMA, S-100 and CD31, confirming a diagnosis of SFT. Although SFT is usually associated with a favourable prognosis, close follow-up is recommended because of the limited information on its long-term behaviour.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
4/7. Bizarre leiomyoblastoma of the cervix uteri. Immunohistochemical and ultrastructural study.A case of bizarre leiomyoblastoma (BL) of the cervix uteri which developed in a 44-year-old premenopausal woman was reported. The tumor was found as a cervical polyp by routine pelvic examination. Histologically, it was composed of epithelioid and bizarre, often multinucleated, giant tumor cells without elevated mitotic counts and necrosis. Electronmicroscopically, abundant myofilaments in epithelioid tumor cells were observed. Immunoreactive desmin, CPK-MM (creatinine kinase mm-isozyme), and myosin could be demonstrated in most of the epithelioid tumor cells. These immunohistochemical findings seemed to reflect on the differentiation of the tumor cells to smooth muscle and provide a reliable evidence for the smooth muscle origin. The histogenesis and relationship between the histopathological findings and clinical behaviour of uterine BL were also discussed.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
5/7. Tonsillar leiomyoma.Tumors of smooth muscle origin are rare in the oral cavity. To date, only eighty-three cases of oral leiomyomas have been reported. A first case of tonsillar leiomyoma in a 73-year-old male is presented. The theories of origin and the various histologic types of oral leiomyomas are discussed. leiomyoma can easily be confused with other spindle-cell tumours. Special stains are necessary to reach a correct diagnosis. It is sometimes difficult to differentiate benign leiomyoma from malignant leiomyosarcoma. The use of mitotic figure count to indicate malignant behaviour is not always reliable. The need for wide surgical excision of the tumour, complete sectioning and examination of the specimen and meticulous follow-up of the patient for evidence of recurrence are emphasized.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
6/7. A 15-year-old girl with an expansively growing tumour.Often decisions have to be made in acute situations, when there is no time for discussion. The decision may have extreme consequences for the patient. The case is reported of a girl aged 15 years with an expansively growing tumour of the uterus. An intra-abdominal haemorrhage was caused by a ruptured vascular connection. The aggressive behaviour of the tumour aroused suspicion of malignancy. At emergency laparotomy the tumour was enucleated from the uterus. uterus and adnexa were preserved. The next problem in decision-making was the doubt concerning the pathological diagnosis: benign cellular leiomyoma or low-grade leiomyosarcoma. Now, 5 years after the laparotomy, there are no signs of recurrence. The problems concerning the diagnoses of 'leiomyoma' and 'leiomyosarcoma' are briefly reviewed.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
7/7. Giant leiomyoma of the oesophagus and cardia. Diagnostic and therapeutic considerations: case report and literature review.A case of giant leiomyoma of the oesophagus and cardia is presented. magnetic resonance imaging was particularly useful for assessing the relationship of the tumour to the neighbouring structures. Radical resection was performed by partial oesophagogastrectomy with intrathoracic oesophagogastrostomy. Giant oesophageal leiomyomas present a diagnostic and therapeutic challenge because of their size and the possibility of malignant behaviour.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |