1/18. Localized hypopigmented mycosis fungoides in a 12-year-old caucasian boy.mycosis fungoides is uncommon during childhood. We describe a Caucasian child who presented a single hypopigmented lesion of mycosis fungoides.- - - - - - - - - - ranking = 1keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
2/18. A case of hypopigmented mycosis fungoides.We experienced a 26-year-old woman in whom widespread hypopigmented macules and patches developed as the initial clinical feature of mycosis fungoides. Histopathological examination confirmed the diagnosis. The patients was treated with PUVA, and the lesion progressively disappeared within five months.- - - - - - - - - - ranking = 0.96136084970218keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
3/18. Leucoderma associated with flares of erythrodermic cutaneous T-cell lymphomas: four cases. The French Study Group of Cutaneous Lymphomas.We describe four patients with erythrodermic cutaneous T-cell lymphomas (two with erythrodermic mycosis fungoides, and two with sezary syndrome) who presented with extensive hypopigmented lesions that occurred during flares of their cutaneous disease. These cases must be distinguished from previously described hypopigmented mycosis fungoides where hypopigmented lesions were the sole manifestation of the lymphoma. In two cases a biopsy was performed on hypopigmented skin, showing an infiltrate of atypical lymphocytes with epidermotropism and absence of melanocytes, as in vitiligo. It is suggested that the hypopigmentation could be due to the cytotoxicity of tumour or reactional lymphocytes directed against melanocytes.- - - - - - - - - - ranking = 0.38454433988087keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
4/18. Hypopigmented mycosis fungoides in childhood and adolescence.We present a case of purely hypopigmented mycosis fungoides of 8-years duration in an 18-year-old woman who responded readily to psoralen plus ultraviolet A (PUVA) treatment. The literature pertaining to hypopigmented mycosis fungoides is reviewed.- - - - - - - - - - ranking = 1.1536330196426keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
5/18. Depigmented genital extramammary Paget's disease: a possible histogenetic link to Toker's clear cells and clear cell papulosis.BACKGROUND: The histogenesis of extramammary Paget's disease (EMPD) is still controversial. Benign pagetoid cells of the nipple first described by Toker and the similar clear cells found in white maculopapules of clear cell papulosis (CCP) have been proposed to be potential precursor cells giving rise to EMPD and primary intraepidermal Paget's disease in the nipple. The observation of a rare case of depigmented EMPD provided us with a chance to examine further the interesting Toker's clear cell/CCP hypothesis. methods: We performed pathologic studies, including Fontana-Masson stain and immunostaining for AE1/AE3 and S100P, on a new case of depigmented EMPD manifesting a 4 x 3 cm hypopigmented-depigmented patch on the root of the penis. RESULTS: The lesion showed extensive intraepithelial proliferation of atypical pagetoid cells with markedly reduced epidermal melaninization but nearly normal numbers of melanocytes. The tumor cells were strongly positive for AE1/AE3 by immunostaining. Some tumor cells displayed tadpole-like morphology resembling the pagetoid cells of CCP. Such morphology was not observed in two random examples of non-depigmented genital EMPD. CONCLUSIONS: The findings of tadpole-shaped pagetoid cells and depigmentation in the present case suggest that depigmented EMPD may be histogenetically related to CCP. Depigmented EMPD should be considered in the differential diagnosis of vitiligo, depigmented mycosis fungoides and lichen sclerosus located along the milk line.- - - - - - - - - - ranking = 0.19227216994044keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
6/18. Hypopigmented mycosis fungoides: a report of 7 cases and review of the literature.Over the last 2 decades, hypopigmented macules have been reported with increasing frequency as an initial presentation of mycosis fungoides (MF). We retrospectively reviewed 7 patients with hypopigmented MF. The mean age was 35 years at disease onset, with a mean of 5.5 years' duration of illness before presentation. All of our patients were Fitzpatrick skin type IV or V, and most reported pruritus. Histologic findings in all cases were consistent with MF. Treatment with topical nitrogen mustard produced repigmentation in 4 of 6 patients.- - - - - - - - - - ranking = 0.96136084970218keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
7/18. Inflammatory vitiligo-like macules that simulate hypopigmented mycosis fungoides.Two cases of an inflammatory vitiligo-like condition that simulated mycosis fungoides are reported. Both patients presented acquired hypopigmented macules sharply limited by an erythematous and papular border. The clinical aspect was suggestive of inflammatory vitiligo. mycosis fungoides was suspected on skin specimens showing a dense band-like lymphocytic infiltrate with discrete nuclear atypias and marked exocytosis. This infiltrate was made of CD3 positive lymphocytes. CD8 positive lymphocytes were numerous in one case, few in the other. There was a loss of melanocytes in the lesional skin and absence of dominant T-cell clones in both cases. No repigmentation was observed after PUVA or local chemotherapy. The authors emphasized that erythematous and papular borders surrounding hypopigmented macules, CD8 positive lymphocytic infiltrate, absence of T-cell clonal rearrangement are helpful to rule out mycosis fungoides.- - - - - - - - - - ranking = 1.1922721699404keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
8/18. Leukoderma associated with sezary syndrome: a rare presentation.We describe a patient with sezary syndrome who was initially seen with the rare occurrence of both generalized erythroderma and extensive leukoderma of his lower limbs. Apart from the absence of melanocytes in the leukodermic skin, histopathologic features of both areas were identical, showing an infiltrate of atypical lymphocytes with epidermotropism. This form of sezary syndrome-associated leukoderma is clinically distinguishable from hypopigmented mycosis fungoides in which hypopigmented lesions are the sole manifestation of the cutaneous T-cell lymphoma.- - - - - - - - - - ranking = 0.19227216994044keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
9/18. Hypopigmented mycosis fungoides.We report the case of a 25-year-old Jamaican woman with hypopigmented mycosis fungoides. She first developed a hypopigmented patch on her arm at the age of 11 years. Further lesions developed on the trunk and limbs over a period of 10 years. The lesions were completely impalpable. skin biopsy showed an infiltrate of atypical lymphocytes, some with cerebriform nuclei, suggesting a diagnosis of mycosis fungoides. The lesions cleared with puva therapy.- - - - - - - - - - ranking = 1.1536330196426keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
10/18. "Hypopigmented mycosis fungoides" is not always mycosis fungoides!We conducted a critical review of hypopigmented mycosis fungoides in historical perspective with emphasis on criteria clinical and histopathologic for diagnosis of that lymphoma as they are set forth in every article ever written about it. Toward that end, we undertook analysis of each article in the medical literature that mentioned hypopigmentation in mycosis fungoides (34 in toto). Each was scrutinized regarding content, photographs of lesions clinical pictured, and photomicrographs. On the basis of all the information in the 34 publications available to us, we made a determination about which patients had mycosis fungoides without doubt, which surely did not, and which about whom no judgment could be made by us because too little data requisite for such a decision was provided, especially in terms of photographs of lesions clinical and of photomicrographs. To date, 106 patients with "hypopigmented mycosis fungoides" have been reported on. Features clinical and findings histopathologic in 23 of those 106 patients were sufficient to permit us to determine, with a high degree of confidence, whether or not a particular patient truly had mycosis fungoides. In our judgment, 19 patients did have mycosis fungoides, whereas at least four patients did not. In regard to the other 83 patients, the information provided by the authors simply was not sufficient to allow us to come to a decision that we could justify.- - - - - - - - - - ranking = 2.6918103791661keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
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