1/10. Fibrous histiocytoma of the larynx.We present a case of fibrous histiocytoma of the larynx in a young female who presented eight years ago and is still alive and well with no evidence of any regional invasion or distant metastasis. This rare lesion has been described in 30 cases previously of which 26 were malignant and four benign. Our case is unusual in a sense that histologically it has not been possible to determine its exact biological behaviour and growth potential. However, clinically it behaved as a low-grade malignant tumour.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
2/10. Dermatomyofibroma: a report of two cases, one occurring in a child.Dermatomyofibroma is a recently described plaque-like dermal tumour composed of myofibroblasts that usually presents around the shoulder, axilla and posterior neck, often in young adult females. Here, we present two cases, one from the posterior axilla of a 33-year-old female and one from the posterior neck of a 7-year-old male. Both were clinically red-brown lesions with histological and immunohistochemical features diagnostic of dermatomyofibroma. There was no evidence of aggressive biologic behaviour with 3 months and 2 months follow up, respectively. While the majority of dermatomyofibromas present in postpubescent females, the 7-year-old male exemplifies a subgroup occurring in male children which appears to show a particular predilection for the posterior neck.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
3/10. Myxoid plexiform fibrohistiocytic tumour.Plexiform fibrohistiocytic tumour is a low-grade malignant mesenchymal neoplasm of myofibroblastic origin with the capacity for biphasic differentiation toward a fibroblastic or histiocyte-like morphology. We report a case of this rare tumour presenting as a tender subcutaneous nodule on the scalp of a 58-year-old man. Histopathological examination revealed multinodular biphasic proliferation of fibroblast-like and histiocyte-like cells with a few osteoclast-like giant cells. This case is notable for the rare myxoid changes, which may reflect a different behaviour of this tumour when occurring in older people.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
4/10. Plexiform fibrohistiocytic tumor: three unusual cases occurring in infancy.BACKGROUND: Plexiform fibrohistiocytic tumor is a soft-tissue tumor of intermediate malignancy occurring in children and young adults but is only rarely found in infants. The tumor usually involves the upper limbs and is slow growing and painless. recurrence rate is high. Lymph node and systemic metastases can occur, but have never been reported in infants. Clinical behavior in infancy is not known. Histologically, the tumor is characterized by nodules of histiocyte-like and multinucleated cells and fascicles of spindle cells arranged in a plexiform pattern. mitosis, atypia, and nuclear pleomorphism are common but not pronounced. methods AND RESULTS: We report three cases in infants, one of which is congenital, having an unusual topography and a broad histological spectrum. CONCLUSION: In infants, wide excision with large safety margins should be performed as the behaviour of this tumor remains uncertain. Leclerc S, Hamel-Teillac D, Oger P, Brousse N, Fraitag S. Plexiform fibrohistiocytic tumor: three unusual cases occurring in infancy.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
5/10. Malignant fibrous histiocytoma of the larynx.Malignant fibrous histiocytomas of the upper respiratory tract are rare, aggressive mesenchymal neoplasms. We report a case of a glottic malignant fibrous histiocytoma of the larynx on a 54 year old man. Only a few have been reported in the English literature. The clinical behaviour and degree of malignancy of these tumours cannot be predicted. Wide, aggressive excision of the tumour with a margin of normal tissue appears to be the treatment of choice. About two years after total laryngectomy the patient is well and free of disease.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
6/10. Fibrous histiocytoma of the larynx.Fibrous histiocytoma is uncommon in the head and neck region and rare in the larynx. Its behaviour is unpredictable. A case is reported in a 54-year-old male which was treated conservatively initially and which recurred several times over a seven year period. During that time the appearances of the lesion changed from those of a densely collagenous, cytologically benign tumour to those of a richly cellular and potentially malignant neoplasm. laryngectomy was eventually undertaken.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
7/10. Malignant fibrous histiocytoma of the nasopharynx.Malignant Fibrous Histiocytomas (MFH) are uncommon in the head and neck and extremely rare in the nasopharynx. We report a case of MFH arising in the nasopharynx and describe its diagnosis and management. The literature is reviewed and the likely origins of the tumour and its behaviour are discussed.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
8/10. An ultrastructural study of angiomatoid fibrous histiocytoma.We studied the electron microscopy of two tumors which clinically and histologically conformed to what has been described as angiomatoid fibrous histiocytoma, a tumor thought to be of fibrohistiocytic origin. The ultrastructure of one tumor was that of a cellular angioma and the second tumor a vascular lesion with fibroblasts and histiocyte-like mononuclear cells. Our findings suggest that angiomatoid fibrous histiocytomas are basically vascular tumors with fibroblasts and other cells as secondary participants in some lesions. The behaviour of angiomatoid fibrous histiocytoma cannot be predicted from histology. Our findings of different ultrastructural components in histologically non-separable tumors lead to a question whether different ultrastructural composition is correlated with different biological behavior of these tumors. Further studies of similar cases are required if tumor morphology is to be correlated with clinical behavior.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
9/10. Malignant fibrous histiocytoma of the breast.Primary malignant fibrous histiocytoma of the female breast (MFH) occurs very rarely, and only 22 cases have been reported so far. We describe a 42-year-old female in whom MFH of the breast was diagnosed, and review the available literature. In accordance with knowledge concerning the biological and clinical behaviour of breast MFH, either wide local excision or mastectomy combined with axillary lymph nodes dissection is recommended, due to the high rate of recurrence and metastatic potential of this tumour.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
10/10. Fibrous histiocytoma of the larynx.Fibrous histiocytoma has a variable, unpredictable behaviour and potential for malignancy. The treatment of choice is wide local excision, which, in the larynx, entails total laryngectomy. A case of fibrous histiocytoma of the larynx, treated successfully by radiotherapy, is presented. A recurrence was treated with cryosurgery and the patient is well at 10-year follow-up. The pathological characteristics of fibrous histiocytoma and the difficulties of classification are reviewed.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
| | Next -> |