1/14. Gardner's syndrome - a case report.Gardner's syndrome is the association of multiple colonic polyps (familial adenomatous polyposis coli - FAP) with sebaceous cysts and jaw osteomas. The significance of this dominantly inherited condition to the dentist is that the colonic polyps usually undergo malignant change by the fourth decade and the extra-intestinal lesions may be apparent before those in the bowel. As such, early detection of multiple jaw osteomas and/or multiple sebaceous cysts (particularly on the scalp) may lead to appropriate further investigation and treatment which might be life saving. Diagnosis of this condition also has implications for other family members.- - - - - - - - - - ranking = 1keywords = jaw (Clic here for more details about this article) |
2/14. Clinical and radiological findings in Gardner's syndrome: a case report and follow-up study.Gardner's syndrome is characterized by colorectal adenomas, multiple osteomas, especially of the skull, and various soft-tissue tumours. The disease is inherited as an autosomal dominant disorder and all untreated patients will develop colorectal adenocarcinomas. Since the clinical and radiological stigmas in the maxillofacial area, such as exosteal and endosteal osteomas, skin cysts, atypical skin pigmentation and abnormal dental findings or radiopaque lesions can precede the often symptomless adenomas for many years, dentists, maxillofacial surgeons and radiologists should be familiar with the manifestations of this disease. A case is reported to illustrate the dentist's role in the diagnosis of Gardner's syndrome. In a follow-up study of 11 patients with colorectal adenomas, the typical triad of features of Gardner's syndrome was found in eight. In six patients, bony changes were demonstrated by panoramic radiography. It is proposed that radiography of the jaws may serve as a valuable tool for the early detection of carriers of Gardner's syndrome.- - - - - - - - - - ranking = 0.5keywords = jaw (Clic here for more details about this article) |
3/14. Multiple huge osteomas of the mandible causing disfigurement related with Gardner's syndrome: case report.As osteomas of the bones including the jaws may be the initial symptom or clinical finding in the Gardner's syndrome, this entity should always be included in the differential diagnosis. A 20-year-old boy was referred to our clinic from another medical center. Extra-oral examination of the patient revealed an obvious asymmetry and disfigurement of the left mandibular corpus, angle and ramus. A panoramic radiograph revealed two huge osteomas at the angle, ramus and two smaller osteomas at the inferior border of the mandible. At the same time, there were an impacted canine and premolar. Diffuse sclerosis of the whole mandible was also seen. Upon the suspicion of Gardner's syndrome, barium passage radiographs of the intestine were requested and multiple polyps were observed. All of these findings led us to the diagnosis of Gardner's syndrome. The oral and maxillofacial surgeon and the dentist needs to be aware of the components of this entity because manifestations in the head and neck including epidermoid cysts, osteomas, odontomas, exostoses, supernumerary and impacted teeth are common. At the same time, osteomas causing disfigurement on the face related with Gardner's syndrome with increased uptake in scintigraphic examination should be treated by surgical excision of the lesions.- - - - - - - - - - ranking = 5.639653872393keywords = mandible, jaw (Clic here for more details about this article) |
4/14. A case of gardner syndrome with a mutation at codon 1556 of APC: a suggested case of genotype-phenotype correlation in dental abnormality.A 25-year-old man with suspected gardner syndrome was introduced to our hospital by a dentist who, during examination of the patient, had found dental dysplasias and multiple osteomas of the jaw. Radiographs, endoscopy and biopsies revealed adenomatous polyposis of the colon. Genetic analysis of peripheral lymphocytes revealed a one-base deletion at codon 1556 in exon 15 of APC, which caused a frame shift and a premature stop at codon 1564. The pedigree analysis demonstrated five patients in his family who presented with dental abnormality and osteomas in addition to adenomatous polyposis of the colon. Although the relationship between the location of APC mutations and dental abnormalities remains controversial, this case supports the hypothesis that a mutation at around codon 1556 of APC is closely associated with dental abnormality and osteomas.- - - - - - - - - - ranking = 0.5keywords = jaw (Clic here for more details about this article) |
5/14. Multiple and giant mandibular osteomas in a Gardner's syndrome. Case report.Though rare, Gardner's syndrome is a systemic disease with frequent jawbones involvement. Dento-maxillo-facial lesions both in early and in advanced stages should be known by dentists and other specialists. In fact, these lesions should be sought in patients with intestinal polyposis, while they could be the first sign of Gardner's syndrome not yet diagnosed.- - - - - - - - - - ranking = 0.5keywords = jaw (Clic here for more details about this article) |
6/14. Gardner's syndrome: a case report.Gardner's syndrome, with characteristic dental abnormalities and osteomas involving the jaws, is described in an adolescent male. The sinister aspect of the syndrome relates to the malignant potential of intestinal polyps and therefore the need for early diagnosis and prophylactic colectomy. The dentist may be the first health professional to have an opportunity to make an early diagnosis and referral of a patient with Gardner's syndrome, and should therefore be aware of the features of the syndrome that affect the teeth and jaws.- - - - - - - - - - ranking = 1keywords = jaw (Clic here for more details about this article) |
7/14. Multiple radiopaque masses in the jaws.In this report, the less common oral findings occurring in Gardner's syndrome are described, which occurred concurrently with colorectal polyposis. In addition, what clinically appeared as small intestinal polyps, microscopically represented nodular lymphoid hyperplasia, as reported in the literature. review of the literature showed the oral findings reported here are not common and that enzyme assays can help detect polyps at an early stage of this complex syndrome.- - - - - - - - - - ranking = 2keywords = jaw (Clic here for more details about this article) |
8/14. A unilateral mesenchymal disorder of the head.A hitherto undescribed group of lesions consisting of cystic bony lesions, exostosis, fibromatous lesion, unilateral tonsillar hypertrophy, epidermoid cyst (cholesteatoma) and hyperplasia of the mandible confined to the left side of the face is reported. The case may represent a variant of the proteus syndrome.- - - - - - - - - - ranking = 0.85660897873217keywords = mandible (Clic here for more details about this article) |
9/14. Multiple cemental lesions in the jaw bones of a patient with Gardner's syndrome.Unusual multiple lesions of jaws in a middle-aged woman with all classic manifestations of Gardner's syndrome are reported. Clinical examination revealed a diffuse swelling of the mandible and maxilla with bone-like hardness and numerous radiopaque lesions scattered throughout both mandible and maxilla. Impaction of the molar teeth was revealed by roentgenographic examination. Histopathologically, the multiple jaw lesions consisted of trabecular proliferation of hard-tissue which more closely resembled cementum than immature bone or osteoid. It was found to be united with the cementum of tooth-roots through obliteration of the periodontal ligament. The present lesions do not fit into any of the distinct entities of cemental lesions described.- - - - - - - - - - ranking = 4.7132179574643keywords = mandible, jaw (Clic here for more details about this article) |
10/14. The gardner syndrome.The gardner syndrome is characterized by polyposis coli and multiple hard and soft tissue tumors. A case of a 17-year-old male is presented who complained of painless and hard swellings on the angle of the mandible bilateraly. The patient presented the original triad of lesions of the gardner syndrome. On the panoramic X-ray, characteristic radio-opaque lesions (exostoses and enostoses) on the jaws were shown and a compound odontoma was detected in the left side of the mandible.- - - - - - - - - - ranking = 2.2132179574643keywords = mandible, jaw (Clic here for more details about this article) |
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