1/7. factor vii deficiency first observed at preoperative routine clotting test.factor vii deficiency was first observed in a 24-year-old female in the routine clotting test for tooth extraction. Her factor VII was 22%, mildly below normal limits. factor ix complex was not administered as replacement therapy when her impacted tooth was extracted. There was no sign of abnormal postoperative bleeding. As this disease was a rare disorder, the minimum safe level of factor VII for tooth extraction was unknown. We had a opportunity to study a patient with this disorder observed in the preoperative routine clotting test for tooth extractions.- - - - - - - - - - ranking = 1keywords = extraction (Clic here for more details about this article) |
2/7. Multiple extractions in a patient with factor vii deficiency.Multiple extractions were carried out in a patient with factor vii deficiency treated with prothrombin complex concentrate. hemostasis and healing were completely satisfactory. The side effects of prothrombin complex concentrate are discussed.- - - - - - - - - - ranking = 1.6666666666667keywords = extraction (Clic here for more details about this article) |
3/7. Possible homozygous factor VIIR disorder associated with fibrinolytic hyperactivity.A family with inherited factor vii deficiency is described. The propositus is a 9-year-old girl with chronic haemorrhagic history of epistaxis and bleeding after tooth extractions. Her factor VII coagulant activity was less than 3% using rabbit thromboplastin. She had a factor VII antigen level of 50%. Both parents were heterozygous for factor vii deficiency. The father had procoagulant factor VII (VII-C) of 44% and factor VII antigen (VII-Ag) of 74%, and the mother had 54% of factor VII-C and 85% of VII-Ag. Her only brother had normal levels of factor VII-C (100%). Additionally, some abnormalities in the fibrinolytic system were detected both in the propositus and her brother with shortened euglobulin lysis times and increased functional levels of plasminogen activator. To our knowledge, the clinical association of inherited factor vii deficiency and familial fibrinolytic disturbances has not been described so far.- - - - - - - - - - ranking = 0.33333333333333keywords = extraction (Clic here for more details about this article) |
4/7. Management of a patient with factor vii deficiency.Several approaches to the dental treatment of patients with Factor VII deficiencies have been explained. The case of a patient with factor vii deficiency who required dental extractions has been presented and the rationale for the treatment used in this case has been discussed.- - - - - - - - - - ranking = 0.33333333333333keywords = extraction (Clic here for more details about this article) |
5/7. Combined hereditary deficiency of factors VII and VIII: a distinct coagulation disorder due to the 'lack' of an autosomal gene controlling factor VII and VIII activation?A patient with a combined hereditary deficiency of factors VII and VIII is presented together with a family study. The main bleeding manifestations were easy bruising and bleeding after tooth extractions. No hemarthrosis was ever observed. The main laboratory features consisted in a mild prolongation of prothrombin time and of partial thromboplastin time. TG test was abnormal and was corrected by the addition of adsorbed normal plasma. Specific assays revealed a moderate defect of factors VII and VIII. All other clotting factors were within normal limits. The factor VII antigen in the propositus was normal or nearly normal. The factor-VIII-associated antigen was also normal. Five additional family members presented the same coagulation pattern and were variably symptomatic. The hereditary transmission pattern seems to be autosomal dominant. The defect appears to be due to a structural abnormality of a gene controlling factors VII and VIII activation.- - - - - - - - - - ranking = 0.33333333333333keywords = extraction (Clic here for more details about this article) |
6/7. Congenital factor vii deficiency presenting as delayed bleeding following dental extraction. A review of the role of factor VII in coagulation.Recent updated models of the coagulation mechanism suggest that factor VII/thromboplastin complex is the main initiator or trigger of coagulation. Factor VII activation of factor ix is likely to be an important activation pathway. Inhibition of factor VII by tissue factor pathway inhibitor may have a regulatory role in the initiation of coagulation. Defining factor VII's interactions in coagulation physiology may lead to answers for some clinical problems in both hemostasis and thrombosis. We describe a 15-year-old Chinese boy with factor vii deficiency and a factor VII level of 0.08 U/ml. His symptoms were recurrent epistaxis and moderate delayed bleeding post-dental extraction. Such specific symptoms have been reported previously in a study of 40 European patients. It is one diagnosis to consider if a patients main symptom is significant post-dental bleeding. It is possible that there is requirement for higher levels of factor VII at these anatomical sites making them the common sites for symptoms in patients with moderate deficiency. case reports of rare clotting factor deficiencies will illustrate what may be important in vitro functions of clotting proteins. Therefore reporting should be encouraged, especially during review and reconsideration of models of the coagulation mechanism.- - - - - - - - - - ranking = 1.6666666666667keywords = extraction (Clic here for more details about this article) |
7/7. Postoperative bleeding with factor vii deficiency: case report.factor vii deficiency was diagnosed during haematological investigation of a patient with multiple occurrences of postoperative bleeding after surgical extraction of an impacted upper left canine. The bleeding was eventually stopped with local measures without resorting to blood product transfusion which may have been necessary if local measures had failed to control bleeding. Abnormalities were also found in subsequent blood profiles and coagulation tests in other members of the patient's family.- - - - - - - - - - ranking = 0.33333333333333keywords = extraction (Clic here for more details about this article) |